Discovery and Development of HDAC Inhibitors: Approaches for the Treatment of Cancer a Mini-review [0.03%]
组蛋白去乙酰化酶抑制剂的发现与开发：癌症治疗的新途径 简介回顾
Roshani Patel,Arjun Modi,Hitesh Vekariya
Roshani Patel
Histone deacetylase (HDAC) inhibitors have emerged as promising cancer therapeutics due to their ability to induce differentiation, cell cycle arrest, and apoptosis in cancer cells. In the present review, we have described the systemic disc...
Short Fragmented Peptides from Pardachirus Marmoratus Exhibit Stronger Anticancer Activities in In Silico Residue Replacement and Analyses [0.03%]
来源于斑鳍刺盖鱼的短链碎片化肽类在计算位点替代和分析中表现出更强的抗癌活性
Yong Hui Wong,Sau Har Lee
Yong Hui Wong
Background: Cancer is a worldwide issue. It has been observed that conventional therapies face many problems, such as side effects and drug resistance. Recent research reportedly used marine-derived products to treat vari...
Exploring the Therapeutic Potential of Ginkgo biloba Polyphenols in Targeting Biomarkers of Colorectal Cancer: An In-Silico Evaluation [0.03%]
银杏多酚在针对结直肠癌生物标志物的治疗潜力探索中：一项基于计算机的评估
Sarra Hamdani,Hocine Allali,Salim Bouchentouf
Sarra Hamdani
Background: Colorectal cancer (CRC) is a major contributor to cancer-related deaths worldwide, driving the need for effective anticancer therapies with fewer side effects. The exploration of Ginkgo biloba, a natural sourc...
Finerenone: A Novel Drug Discovery for the Treatment of Chronic Kidney Disease [0.03%]
非奈酮：一种治疗慢性肾病的新药发现
Akshita Rana,Jagdish K Sahu
Akshita Rana
Background: The most common cause of chronic kidney disease (CKD) is diabetic nephropathy (DN). Primarily mineralocorticoid receptor antagonists (MRAs) (spironolactone and eplerenone), angiotensin-converting enzyme inhibi...
Restoring Impaired Neurogenesis and Alleviating Oxidative Stress by Cyanidin against Bisphenol A-induced Neurotoxicity: In Vivo and In Vitro Evidence [0.03%]
黄酮类花色苷对双酚A诱导的神经毒性下海马神经营养不良和氧化应激的改善：体内与体外实验证据
Swathi Suresh,Chitra Vellapandian
Swathi Suresh
Background: Bisphenol A (BPA) is a known neurotoxic compound with potentially harmful effects on the nervous system. Cyanidin (CYN) has shown promise as a neuroprotective agent. ...
Effect of Niosomal Encapsulation of Quercetin and Silymarin and their Combination on Dimethylnitrosoamine-induced and Phenobarbitalpromoted Hepatocellular Carcinoma in Rat Model [0.03%]
诺里osomal封装的檞皮素和水飞蓟素及其组合对大鼠模型中二甲基亚硝胺诱导和苯巴比妥促进的肝细胞癌的影响
Devendra S Shirode,Dinesh Raut,Nikita Saraswat
Devendra S Shirode
Background: Hepatocellular carcinoma is a particularly dangerous and severe kind of liver cancer. Many anticancer drugs fail to complete the treatment of hepatocellular carcinoma without any side effects. There should be ...
Synthesis and Characterization of Baicalein-loaded Aquasomes: An In vitro and In silico Perspective for Diabetes Mellitus [0.03%]
黄芩素加载的水囊泡的合成与表征：糖尿病的体内外和计算机模拟研究视角
Vinay Goyal,Bhavna Kumar,Diwya Kumar Lal et al.
Vinay Goyal et al.
Background: Millions of individuals worldwide suffer from metabolic abnormalities induced by diabetes. Baicalein, a flavonoid, has shown several properties in various treatments with potential properties, including anti-i...
Tutumoni Kalita,Ankita Choudhury,Anshul Shakya et al.
Tutumoni Kalita et al.
Background: Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmac...
Immunomodulation Induced in BALB/c Mice after Subacute Exposure to Hydroalcoholic Extract of Artimisia Dracunculus [0.03%]
亚急性接触龙蒿水醇提取物对BALB/c小鼠免疫调节的影响
Fatemeh Forouzanfar,Mostafa Moshirian-Farahi,Hassan Rakhshande et al.
Fatemeh Forouzanfar et al.
Introduction: Tarragon, with the scientific name of Artemisia dracunculus, is a perennial herbaceous plant with a wide spectrum of pharmacologic properties. In the current investigation, BALB/c mice were used to examine t...
Investigating the Antioxidant Capacity of Newly Synthesized Flavonoids via DPPH Assay [0.03%]
通过DPPH测定法研究新合成的黄酮类化合物的抗氧化能力
Umang Shah,Mehul Patel,Samir Patel et al.
Umang Shah et al.
Background: Numerous naturally occurring and artificially synthesized flavonoids have garnered attention for their impressive ability to combat oxidative stress and scavenge free radicals when evaluated in laboratory sett...