Liquisolid Technique: A Novel Technique with Remarkable Applications in Pharmaceutics [0.03%]
液体制剂技术——药学中一项极具应用价值的新型技术
Sahibpreet Singh,Jyoti Singh,Disha Arora
Sahibpreet Singh
Recently, it has been observed that newly developed drugs are lipophilic and have low aqueous solubility issues, which results in a lower dissolution rate and bioavailability of the drugs. To overcome these issues, the liquisolid technique,...
New 1,3,4‒oxadiazole Quinazolines as Potential Anticancer Agents: Design, Synthesis, Biological Evaluation, and In silico Studies [0.03%]
新型1,3,4-噁二唑喹唑啉类抗肿瘤化合物的设计、合成、生物评价及分子对接研究
Venkanna Gujja,Kumaraswamy Sadineni,Shiva Kumar Koppula et al.
Venkanna Gujja et al.
Background: A novel series of 1,3,4‒oxadiazole connected to derivatives of quinazolinone (7a-e and 8a-f) was synthesized in the current investigation, and its anticancer and Topoisomerase‒ II inhibitory activity was eva...
Repurposing Phytochemicals against Breast Cancer (MCF-7) using Classical Structure-Based Drug Design [0.03%]
基于结构的经典药物设计在乳腺癌(MCF-7)治疗中重新利用植物化学物质
Faten Essam Hussain Aldoghachi,Amjad Oraibi,Noor Hamid Mohsen et al.
Faten Essam Hussain Aldoghachi et al.
Background: The significant public health effect of breast cancer is demonstrated by its high global prevalence and the potential for severe health consequences. The suppression of the proliferative effects facilitated by...
Spinacia Oleracea: Exploring the Therapeutic Potential in Persian Medicine and Modern Pharmacology [0.03%]
菠菜（Spinacia oleracea）在波斯医学和现代药理学中的治疗潜力探究
Fatemeh Akbari,Melika Mollaei,Pendar Argani et al.
Fatemeh Akbari et al.
Background: Spinach is a widely cultivated dark leafy vegetable highly regarded for its medicinal properties in traditional Persian medicine. It is rich in vitamins, minerals, flavonoids, carotenoids, and other bioactive ...
In-silico Studies, Synthesis, and Antacid Activities of Magnesium (II) Complexes [0.03%]
镁(Ⅱ)配合物的抗酸作用的计算机模拟研究及合成实验
Basuki Nath Jha,Richa Kothari,Anurag Agrawal
Basuki Nath Jha
Background: Nowadays, acidity is a severe problem worldwide caused by excessive gastric acid secretion by the stomach and proximal intestine. Objective: ...
Krushna Abhale,Addepalli Veeranjaneyulu,Shivani Desai
Krushna Abhale
A persistent long-standing, inflammatory skin condition that is brought on by a variety of factors is psoriasis. It is distinguished by itchy, scaly, reddish plaques, particularly on areas of the body that are frequently chafed, including t...
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents [0.03%]
基于Febuxostat的酰胺类似物作为抗炎剂的药效团生成，基于配体的虚拟筛选，基于原子的三维定量构效关系和分子对接研究相结合
Trupti Chitre,Aniket Bhatambrekar,Purvaj Hirode et al.
Trupti Chitre et al.
Background: A defence mechanism of the body includes inflammation. It is a process through which the immune system identifies, rejects, and starts to repair foreign and damaging stimuli. In the world, chronic inflammatory...
Synthesis, Molecular Docking, and Biological Evaluation of Novel Indole--triazole Conjugates [0.03%]
新型吲哚-三氮唑连接化合物的合成，分子对接及生物活性评价
Paras Berwal,Suman Rohilla,Nancy Mathur et al.
Paras Berwal et al.
Background: Indole-triazole conjugates have emerged as promising candidates for new drug development. Their distinctive structural characteristics, coupled with a wide array of biological activities, render them a captiva...
Effects of Mesenchymal Stem Cell-conditioned Media with Natural Immunomodulatory Agent Resveratrol on Type 1 Diabetes [0.03%]
含有天然免疫调节剂白藜芦醇的间充质干细胞条件培养基对1型糖尿病的影响
Krushna Abhale,Addepalli Veeranjaneyulu,Shivani Desai et al.
Krushna Abhale et al.
Background: Type 1 diabetes mellitus (T1DM) is a condition marked by elevated blood sugar levels and primarily recognized by the destruction of beta cells caused by an autoimmune attack, which is a significant characteris...
Negar Omidkhah,Farzin Hadizadeh,Razieh Ghodsi et al.
Negar Omidkhah et al.
Introduction: Numerous clinical trials are currently investigating the potential of nitric oxide (NO) as an antiviral agent against coronaviruses, including SARS-CoV-2. Additionally, some researchers have reported positiv...