Vaccine Designing Technology against Leishmaniasis: Current Challenges and Implication [0.03%]
莱什曼病疫苗设计技术：当前挑战及展望
Jyoti Gupta,Yukta Menon,Subodh Kumar et al.
Jyoti Gupta et al.
Leishmaniasis, a debilitating disease caused by protozoan parasites of the genus Leishmania and transmitted by the bite of a female sandfly, continues to present significant challenges despite ongoing research and collaboration in vaccine d...
In-silico Studies, Design, and Synthesis of Pyrimidine-linked Benzothiazoles for its Anticonvulsant Potential [0.03%]
基于计算机的设计、合成含嘧啶并苯并噻唑类化合物及其抗癫痫活性研究
Amol Kale,Rajendra Kakde,Smita Pawar et al.
Amol Kale et al.
Background: The objective of the study was to design and synthesize a series of N-(6-substituted-1,3-benzothiazole- 2-yl)-2-{[6-(3-substitutedphenyl)-5-cyano-2-sulfanylpyrimidine-4-yl)]amino}acetamide derivatives BPD (1-1...
Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by Radiofrequency Electromagnetic Radiation from Cell Phones via Upregulation of the CREM Signaling Pathway [0.03%]
射频电磁辐射诱导的垂体-卵巢功能障碍及西洋参多糖的改善作用及其机制研究
Oyetunji A Oyewopo,Olabimpe C Badejogbin,Isaac O Ajadi et al.
Oyetunji A Oyewopo et al.
Background: Panax ginseng (PG) is a plant that contains ginsenosides, which are considered adaptogens that confer cellular protection. However, the impact of PG on pituitary-ovarian dysfunction and subsequent infertility ...
Nafiur Rahman,Arpita Gope,Jayeeta Khanrah et al.
Nafiur Rahman et al.
Insects are the most numerous and diverse collection of organisms on earth. Around the world, human societies have utilised insects and the materials derived from them as medical resources. These arthropods use chemistry, like all other spe...
Shubhashree Das,Gurudutta Pattnaik,Sovan Pattanaik et al.
Shubhashree Das et al.
Coming to the edge of disease manufacturing in the twenty-first-century, breast cancer occupies a terrifying scenario in the globe, especially in adult women. Its curiosity endeavours remarkable advances made during the past decennaries for...
Preclinical Data Extrapolation to Clinical Reality: A Translational Approach [0.03%]
从临床前数据外推到临床现实：转化医学方法
Prakhar Varshney,Phool Chandra
Prakhar Varshney
In vivo investigations are much more complex than trials conducted in a test tube; the results sometimes aren't as illuminating and could raise more questions than answers. Preclinical data projection into clinical truth is a transcriptiona...
In Silico approach: Design an Optimized shRNA against RUNX1 Gene to Target HIV [0.03%]
基于计算机的设计：针对HIV设计优化了的RUNX1基因靶向shRNA片段
Rezvan Kakavand-Ghalehnoei,Elham Patrad,Mehrdad Ravanshad
Rezvan Kakavand-Ghalehnoei
Human Immunodeficiency Virus (HIV) is a retrovirus with single-stranded RNA that leads to the challenging disease of acquired immunodeficiency syndrome (AIDS). Combination antiretroviral therapy (cART) can prevent the progression of the dis...
Harnessing the Therapeutic Potential of Dillenia indica: An Overview of Recent Dosage Form Developments [0.03%]
密蒙花的治疗潜力研究进展概述
Aditya Bora,Pallab Kalita,Parimita Kalita et al.
Aditya Bora et al.
Dillenia indica, commonly known as Elephant Apple, is a significant medicinal plant found in Assam, North-East India. This evergreen shrub or small to medium-sized tree possesses not only tasty components but also a plethora of beneficial t...
Virtual Screening, Docking, and Designing of New VEGF Inhibitors as Anti-cancer Agents [0.03%]
虚拟筛选、分子对接及抗肿瘤活性的VEGF抑制剂的设计与合成
Shivkant Patel,Vinay Ranjan Singh,Ashok Kumar Suman et al.
Shivkant Patel et al.
Background: VEGFR-2 tyrosine kinase inhibitors are receiving a lot of attention as prospective anticancer medications in the current drug discovery process. ...
Drug Repositioning: A Monetary Stratagem to Discover a New Application of Drugs [0.03%]
药物再定位：发现药物新用途的一种经济策略
Ankur Rohilla,Seema Rohilla
Ankur Rohilla
Drug repurposing, also referred to as drug repositioning or drug reprofiling, is a scientific approach to the detection of any new application for an already approved or investigational drug. It is a useful policy for the invention and deve...