Francisco Epelde
Francisco Epelde
Delirium represents a significant clinical, economic, and societal challenge, frequently arising in hospitalized patients due to multiple factors, including pharmacological triggers. Recognizing and preventing delirium is crucial to improvi...
Dealing with Early-Onset Schizophrenia and the Role of Lurasidone: An Expert Opinion [0.03%]
早发性 schizophrenia的治疗及Lurasidone的作用：专家意见
Sergio De Filippis,Gabriele Masi,Gianluca Serafini et al.
Sergio De Filippis et al.
Compared to schizophrenia in adults, Early Onset Schizophrenia (EOS) features diagnostic, clinical, and therapeutic peculiarities that are the subject of ongoing discussion among psychiatrists and neuropsychiatrists. This article presents t...
Therapeutic Approaches Interfering with Nuclear Localization Signals: An Emerging Strategy for CNS-Related Diseases [0.03%]
干扰核定位信号的治疗策略：中枢神经系统相关疾病的新兴策略
Margrate Anyanwu,Matteo Giannangeli,Alessandra Gianoncelli et al.
Margrate Anyanwu et al.
Although medicinal chemistry is constantly looking for new therapeutic approaches against pathological conditions affecting the central nervous system (CNS), such as neurodegeneration and cancer, this quest has not been fully successful yet...
Neural Networks of Knowledge: Ontologies Pioneering Precision Medicine In Neurodegenerative Diseases [0.03%]
神经知识网络：精准医学在神经退行性疾病中的本体论先驱研究
Pooja Mittal,Rupesh Kumar Gautam,Himanshu Sharma et al.
Pooja Mittal et al.
The review focuses on the ways that ontologies are revolutionising precision medicine in their effort to understand neurodegenerative illnesses. Ontologies, which are structured frameworks that outline the relationships between concepts in ...
Targeting the cGAS-STING Pathway: Modulating Inflammation, Oxidative Stress, and Autophagy for Novel Depression Therapies [0.03%]
靶向cGAS-STING通路：调节炎症、氧化应激和自噬以期获得新型抑郁症疗法
Wen Ma,Shanshan Chu,Yumei Ma et al.
Wen Ma et al.
The pathological mechanisms underlying depression, a prevalent mental disorder, remain only partially elucidated despite extensive research efforts. Recent advancements have underscored the pivotal roles of multiple biological processes in ...
Alessandro Pezzini
Alessandro Pezzini
Assessment Value of Electromyography for Bortezomib-Related Peripheral Neuropathy [0.03%]
电生理检测在评估硼替佐米外周神经毒性中的价值
Yijun Shen,Zhen Zhang,Yuchen Liu et al.
Yijun Shen et al.
Introduction: This study investigates the relationship between National Cancer Institute Common Terminology Criteria (NCI-CTC) for grading bortezomib-induced peripheral neuropathy (BIPN) and objective motor/sensory nerve ...
Diabetes, Alzheimer's Disease Risk Factors, and the Cafeteria Diet: A Comprehensive Review [0.03%]
饮食因素和cafeteria饮食与阿尔茨海默病及糖尿病的关系：综述
Md Abubakar,Aditi Giri,Falguni Goel et al.
Md Abubakar et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multifaceted risk factors, including diet and metabolic dysfunction. The rising prevalence of AD and diabetes has drawn attention to their shared pathophysiological m...
Peroxiredoxin 6 Alone or in Combination with Fingolimod Ameliorates EAE [0.03%]
单独使用或与芬戈莫德联合使用过氧化氢酶6可改善自身免疫性脑脊髓炎
Lunin S M,Novoselova E G,Glushkova O V et al.
Lunin S M et al.
Introduction: Multiple Sclerosis (MS) is characterized by the infiltration of leukocytes into the nervous tissue, and disruption of the Blood-Brain Barrier (BBB) is one of the main factors in the progression of MS and its...
Experimental Evaluation of QY-69: A Butyrylcholinesterase Inhibitor with Anti-Glioblastoma Efficacy [0.03%]
QY-69的抗胶质母细胞瘤活性及其胆碱酯酶抑制作用的实验研究
Kaixuan Wang,Ziyao Lu,Yuetong Duan et al.
Kaixuan Wang et al.
Introduction: Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor, characterized by poor prognosis. Moreover, cognitive impairment from the tumor and its treatments compromises patients' qua...