A Novel Network Pharmacology Strategy for Retrieving a Key Functional Component Group and Mechanisms in the Di-Huang-Yin-Zi Treatment of Parkinson's Disease [0.03%]
基于网络药理学策略的二黄阴子治疗帕金森病关键功能成分群及机制研究
Qi Qu,Yanfei Tong,Yi Li et al.
Qi Qu et al.
Introduction: Parkinson's Disease (PD) is a common and difficult-to-cure chronic neurodegenerative disorder. Current medications often target a single pathway and can have certain side effects. In contrast, traditional Ch...
Ginsenoside Rg2 Ameliorates Alzheimer's Disease by Alleviating Neuroinflammation in APP/PS1 Mice [0.03%]
稀有人参皂苷Rg3通过减轻小胶质细胞活化治疗阿尔茨海默病
Dilida Yeerkenbieke,Yue Guan,Jing Cui et al.
Dilida Yeerkenbieke et al.
Introduction: Ginsenoside Rg2 (GRg2), a naturally occurring triterpenoid derived from ginseng rhizomes, exhibits neuroprotective properties. Neuroinflammation is recognized as one of the key pathogenic mechanisms underlyi...
Molecular Mechanisms of cGAS-STING Axis and Mitochondrial Dysfunction-Related Diseases in Humans: A Comprehensive Review [0.03%]
人类cGAS-STING轴和线粒体功能障碍相关疾病的分子机制综述
Xingtong Shen,Hantao Chen,Jishan Zheng et al.
Xingtong Shen et al.
Mitochondria play a critical role in immune cell differentiation, activation, and the regulation of innate immune responses. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key mediator of cytosolic DN...
Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions [0.03%]
全身麻醉诱导的神经环路机制：目前进展与未来方向
Yanfang Yin,Yaxin Teng,Wenying Chi et al.
Yanfang Yin et al.
General anaesthesia is traditionally divided into three distinct stages: induction, maintenance, and recovery. However, much of the existing literature has primarily focused on elucidating the mechanisms involved in the recovery phase, yiel...
PGx-Based in silico Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse [0.03%]
基于PGx的计算机分析确定基因、糖代谢和多巴胺能功能障碍途径与慢性可卡因使用和误用之间的交互作用
Alireza Sharafshah,Panayotis K Thanos,Albert Pinhasov et al.
Alireza Sharafshah et al.
Introduction: Our team conducted a pharmacogenomics (PGx) analysis to evaluate the interactions between cocaine, glucose metabolism, and functional connectivity using in-depth silico PGx methods. ...
Unraveling the Role of Perivascular Macrophages in Alzheimer's Disease: Insights from the Crosstalk between Immunometabolism and Ferroptosis [0.03%]
阿尔茨海默病血管周围巨噬细胞的作用机制：免疫代谢与铁死亡串话的见解
Xiaolei Miao,Wei Yue,Jinxu Wang et al.
Xiaolei Miao et al.
Introduction: Recent evidence increasingly supports a potential role of Perivascular Macrophages (PVMs), a unique subpopulation of brain immune cells, in the pathogenesis of Alzheimer's disease (AD). Strategically positio...
An Efficient Neuro-framework for Brain Tumor Classification Using a CNN-based Self-supervised Learning Approach with Genetic Optimizations [0.03%]
一种基于CNN的自监督学习方法与遗传优化相结合的有效神经框架用于脑肿瘤分类
Paripelli Ravali,Pundru Chandra Shaker Reddy,Pappula Praveen
Paripelli Ravali
Introduction: Accurate and non-invasive grading of glioma brain tumors from MRI scans is challenging due to limited labeled data and the complexity of clinical evaluation. This study aims to develop a robust and efficient...
Ferdinando Nicoletti
Ferdinando Nicoletti
Myocardial Inflammation as Key Mediator of Heart-brain Interaction After Myocardial Ischemia/Infarction: Mechanistic Exploration of Post-Myocardial Infarction Cognitive Dysfunction [0.03%]
心肌炎症在心肌缺血/梗死之后的心脑相互作用中扮演关键媒介角色：心梗后认知功能障碍的发病机制探讨
Linhan Wang,Meng Mao,Hailong Bing et al.
Linhan Wang et al.
Myocardial Infarction (MI) is a severe cardiovascular event, causing not only substantial damage to the heart but also potentially exerting a profound impact on brain function through a complex cardiac-brain interaction mechanism. The patho...
MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population [0.03%]
APOE以外的生物标志物在阿尔茨海默病风险评估中的作用：以约旦人群Tau基因多态性为例叙事综述研究
Alaa A A Aljabali,Almuthanna Alkaraki,Mohammad A Obeid
Alaa A A Aljabali
Introduction: Genetic variations in the microtubule-associated protein tau (MAPT) gene play a central role in Alzheimer's disease (AD) pathogenesis. Two major MAPT haplotypes, H1 and H2, show differential associations wit...