The MID1IP1/S100A10-mGluR5 Axis in Seizures: Immune-Metabolic Crosstalk and Enhanced Therapeutic Efficacy of Benfotiamine/Phenytoin Combination [0.03%]
MID1IP1/S100A10-mGluR5轴在癫痫发作中的作用：免疫-代谢交叉 talk 及维生素B1亚砜/苯妥英联合治疗的增效作用
Sijun Li,Muhua Zhou,Xing Wei et al.
Sijun Li et al.
Introduction: Epilepsy, characterized by recurrent seizures, is associated with dysregu-lated Fatty Acid (FA) metabolism and metabotropic glutamate receptor 5 (mGluR5) signaling. However, the contribution of FA metabolism...
Global Research Trends of Protein Post-translational Modifications in Alzheimer's Disease: A Bibliometric Analysis [0.03%]
阿尔茨海默病蛋白质翻译后修饰研究趋势的 bibliometrix 分析
Zixin Wei,Haifeng Qian,Chunmei Dai et al.
Zixin Wei et al.
Background: In recent years, a considerable body of research has increasingly underscored the critical roles that protein Post-Translational Modifications (PTMs) play in the pathogenesis of Alzheimer's Disease (AD). Howev...
PCSK9 Inhibitors for Secondary Prevention in Patients with Prior Stroke: A PRISMA-Guided Systematic Review [0.03%]
PCSK9抑制剂用于既往卒中患者二级预防：一项遵循PRISMA指南的系统评价
Francisco Epelde
Francisco Epelde
Background: Survivors of ischemic stroke face a persistently high risk of recurrent cerebrovascular and cardiovascular events. Intensive lipid-lowering therapy is central to secondary prevention, yet substantial residual ...
PP2A: Decoding Its Structure, Regulation and Therapeutic Applications in Neurological Disorders [0.03%]
PP2A：解码其结构、调节机制及其在神经疾病治疗中的应用
Jingyi Tian,Rui Yao,Lu Shen et al.
Jingyi Tian et al.
Protein phosphatase 2A (PP2A) is a highly conserved serine/threonine phosphatase that plays a pivotal role in maintaining cellular homeostasis by counterbalancing kinase activity. As a heterotrimeric enzyme composed of scaffolding, regulato...
Maria Antonietta Barbieri,Elena Bruzzone,Edoardo Spina et al.
Maria Antonietta Barbieri et al.
Lithium has remained one of the most established treatments for mood disorders for more than seven decades. Evidence supports its effectiveness in the management of acute manic episodes and in the prevention of relapse in bipolar disorder d...
Mechanisms and Applications of Transcranial Ultrasound Stimulation in Neurological Disorders and Psychiatric Conditions [0.03%]
经颅超声刺激在神经精神疾病中的机制和应用
Mingyue Wei,Yunjie Sui,Xue Xia
Mingyue Wei
Transcranial ultrasound stimulation (TUS) is an emerging non-invasive neuromodulation strategy with high spatial precision and the ability to target both cortical and deep brain regions. This review summarizes recent progress in low-intensi...
Targeting Ferroptosis-associated Histone Acylation for Amelioration of Neurological Disease [0.03%]
靶向铁死亡相关组蛋白乙酰化以改善神经性疾病
Xin Guo,Tianchen Jiang,Waner Ma et al.
Xin Guo et al.
Ferroptosis is an iron-dependent, lipid peroxidation-driven form of programmed cell death. There is substantial evidence supporting the critical role of ferroptosis in multiple neurological diseases, including stroke, Alzheimer's disease, P...
Targeting the Adipose-Brain Axis: Adipokines as Key Modulators of Cognitive Dysfunction [0.03%]
靶向脂肪组织-脑轴：脂连蛋白作为认知功能障碍的关键调节因子
Phonphimon Ruankham,Kitti Thiankhaw,Nipon Chattipakorn et al.
Phonphimon Ruankham et al.
Introduction: Adipose tissue is an active endocrine organ that secretes adipokines capable of modulating brain function through metabolic, inflammatory, vascular, and neurotrophic pathways. Emerging evidence suggests that...
Esketamine in Treatment-Resistant Depression: Clinical and Translational Perspectives [0.03%]
氯胺酮在难治性抑郁症中的临床和转化研究视角
Zofia Śledzikowska,Agata Marianna Pasternak,Ksawery Wojciechowski et al.
Zofia Śledzikowska et al.
Background: Esketamine, an intranasally administered N-methyl-D-aspartate (NMDA) receptor antagonist, represents a significant advancement in the treatment of Major Depressive Disorder (MDD), particularly among patients w...
Integrative Multi-Omics and Mendelian Randomization Analysis Identify Core Genes and Potent Drug Targets for Insomnia [0.03%]
整合多组学和孟德尔随机化分析识别失眠的核心基因和潜在药物靶点
Yemen A,Zhenghua Wu,Wenqing Shi et al.
Yemen A et al.
Introduction: Insomnia is a common clinical sleep disorder, for which current medications only relieve symptoms symptomatically and highly specific therapeutic targets are limited. This study integrates multi-omics analys...