Neuropharmacological Potential of Olfactory Receptors: Integrative Structural Insights for Novel Therapeutic Strategies [0.03%]
嗅觉受体的神经药理学潜力：新型治疗策略的结构洞察
Nidhi Dubey,Ankish Arya,Prabhat Tripathi et al.
Nidhi Dubey et al.
The human olfactory system senses an exceptionally wide variety of odorant molecules by utilizing olfactory receptors (ORs), which are a very extensive and diverse family of genes in the human genome. These receptors belong to the Class A c...
Cortico-white Matter Functional Coupling as a Biomarker of Alzheimer's Disease Progression and rTMS Therapeutic Efficacy [0.03%]
皮质-白质功能耦合作为阿尔茨海默病进展和经颅磁刺激治疗效果的生物标志物
Yukai Liu,Yuan Zhang,Wenao Zheng et al.
Yukai Liu et al.
Introduction: Alzheimer's disease (AD) spectrum disorders are characterized by progressive cognitive decline, with white matter degeneration and disrupted cortico-cortical connectivity as early features. Cortico-white mat...
Hippocampal Structural Changes and Antipsychotic Medication in Schizophrenia Spectrum Disorder: A Systematic Review and Meta-Analysis of Longitudinal MRI Studies Highlighting Current Evidence Gaps [0.03%]
精神分裂症谱系障碍中海马结构变化及抗精神病药物治疗的系统评价和纵向磁共振成像研究 meta 分析：强调当前证据缺口
Nobuhisa Kanahara,Hiroshi Kimura,Hiroshi Komatsu et al.
Nobuhisa Kanahara et al.
Introduction: The hippocampus is among the most affected brain structures in schizophrenia and plays a central role in the core pathology of psychotic disorders. Despite observations that hippocampal structural deficits e...
Molecular Mechanisms and Therapeutic Strategies in Parkinson's Disease: From Pathogenic Signaling to Drug Development [0.03%]
帕金森病的分子机制和治疗策略：从致病信号到药物研发
Zhihui Shen,Jiaxin Cheng,Linlin Wang et al.
Zhihui Shen et al.
Parkinson's Disease (PD) is the second most common neurodegenerative disease after Alzheimer's Disease (AD), yet no effective disease-modifying therapy is currently available. Its pathogenesis is highly complex, involving multiple interacti...
Munazza Ahmed,Ruba A Zenati,Shab M Alkhoujah et al.
Munazza Ahmed et al.
Chemotherapy-induced cognitive impairment, widely known as chemobrain, has emerged as a pressing concern as cancer incidence and treatment success continue to rise worldwide. Patients frequently report persistent deficits in memory, attenti...
Naotaifang Formula Suppresses Ferroptosis by Ameliorating Mitochondrial Biogenesis Through the Nrf2/TFAM Pathway in Ischemic Stroke [0.03%]
脑复方通过Nrf2/TFAM途径改善线粒体生物发生抑制缺血性卒中铁死亡
Mengzhen Wei,Danhong Liu,Qiusi Du et al.
Mengzhen Wei et al.
Introduction: This study aimed to investigate whether activating the Nrf2/TFAM pathway boosts mitochondrial biogenesis, reduces ferroptosis in ischemic stroke (IS), and evaluates Naotaifang (NTF) formula's therapeutic pot...
Depression in Epilepsy: Drug and Non-Drug Interventions Based on Multimodal Pathogenesis [0.03%]
癫痫抑郁的药物和非药物治疗：基于多模态发病机制
Qingyang Zhan,Fanyi Kong,Yijie Liu et al.
Qingyang Zhan et al.
Depression is a common comorbidity in patients with epilepsy, significantly impacting their quality of life. However, the precise mechanisms underlying depression in epilepsy remain unclear. This review synthesizes the latest research on th...
Micronutrient-Assisted Biomaterial Strategies as Neuropharmacological Modulators of Neuroinflammation and Oxidative Stress in Neurodegenerative Diseases [0.03%]
作为神经药理学调节剂的微量营养素辅助生物材料策略在神经炎症和氧化应激中的作用及其在神经退行性疾病中的应用
Riya Sarkar,Koyel Banerjee,Sangita Das et al.
Riya Sarkar et al.
Neurodegeneration results from the convergence of several molecular processes, including inflammation in the brain (i.e., neuroinflammation), elevated levels of free radicals that damage cells, mitochondrial dysfunction, and the inability t...
Plasma Total and Phosphorylated α-Synuclein as Biomarkers in Multiple System Atrophy: A Multicenter Study [0.03%]
血浆总α-突触核蛋白和磷酸化α-突触核蛋白作为多系统萎缩生物标志物的多中心研究
Xinrong Yuan,Linlin Wan,Zhao Chen et al.
Xinrong Yuan et al.
Background: The diagnostic value and longitudinal dynamics of plasma α-synuclein (α-syn) and phosphorylated α-syn (p-α-syn) in multiple system atrophy (MSA) remain incompletely understood. This study aimed to investig...
Advances in Neuroinflammation and Neuroprotection: Mechanisms and Therapeutic Frontiers [0.03%]
神经炎症和神经保护的机制及治疗前景研究进展
Pundru Chandra Shaker Reddy,Yadala Sucharitha
Pundru Chandra Shaker Reddy