The Role of Gut Bacteria and Plasma Metabolites in Predicting Post-Stroke Depression in Patients with Acute Ischemic Stroke [0.03%]
肠道菌群及血浆代谢物在急性缺血性卒中患者预测卒中后抑郁中的作用
Lulu Wen,Tong Si,Chuming Yan et al.
Lulu Wen et al.
Introduction: Early diagnosis of Post-Stroke Depression (PSD) is challenging. This study aimed to identify possible biomarkers in gut microbiota and plasma metabolites within 72 hours after Acute Ischemic Stroke (AIS) to ...
Advances in the Mechanism of ceRNA Regulation in Postoperative Cognitive Dysfunction [0.03%]
术后认知障碍ceRNA调控机制研究进展
Qiang Liu,Lin-Hui Ma,Chen-Rui Zhou et al.
Qiang Liu et al.
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication in elderly patients after surgery, characterized by cognitive changes, including impaired learning and memory, reduced attention, and mental disorder...
Structural and Functional Determinants of ARIA-H Risk in Anti-Amyloid Monoclonal Antibodies: A Comparative Mechanistic Framework for Alzheimer's Immunotherapy Development [0.03%]
针对阿尔茨海默病免疫治疗的抗淀粉样蛋白单克隆抗体ARIA-H风险的结构和功能决定因素及其比较机制框架
Dinghao An,Xinxin Zou,Yun Xu
Dinghao An
Introduction: Amyloid-beta-targeting monoclonal antibodies (mAbs) for Alzheimer's disease frequently induce amyloid-related imaging abnormalities with hemorrhage (ARIA-H), yet systematic comparisons of ARIA-H incidence ac...
A Decade of Research on C9orf72 in Frontotemporal Dementia (2014-2024): A Bibliometric Analysis of Global Trends and Hotspots [0.03%]
C9orf72基因在额颞叶痴呆研究的十年回顾（2014-2024）：全球趋势与热点主题的文献计量分析
Miao He,Sheng Zeng,Zhenchu Tang et al.
Miao He et al.
Introduction: Frontotemporal dementia (FTD) is the third most frequent dementia and the leading dementia subtype in individuals under 65. The discovery of C9orf72 (chromosome 9 open reading frame 72) GGGGCC abnormal expan...
Yujie Ma,Xinyue Wang,Minghuang Gao et al.
Yujie Ma et al.
Alzheimer's disease (AD) is a progressive disease characterized by significant cognitive decline, posing a substantial threat to life. Neuronal loss and dysfunction are responsible for the cognitive decline and behavioral disturbances obser...
Pharmacodynamics and Pharmacokinetics of Ublituximab Compared with Other Anti-Cd20 Monoclonal Antibodies for Multiple Sclerosis Treatment [0.03%]
用于多发性硬化症治疗的Ublituximab与其它抗CD20单克隆抗体相比在药理动力学和药代动力学上的差异分析
Monica Margoni,Luca Battistini,Diego Centonze et al.
Monica Margoni et al.
The therapeutic scenario for Multiple Sclerosis (MS) has expanded rapidly over the last few years. Among the available treatments, anti-CD20 monoclonal antibodies, including rituximab, ocrelizumab, ofatumumab, and ublituximab, have shown si...
Unraveling Complex Interactions Mechanisms Linking PTSD and Chronic Diseases [0.03%]
解开PTSD与慢性疾病相互作用机制的复杂关系
Celina Cavalcante Muniz Gomes,Joelson Germano Crispim,Michelle Melgarejo da Rosa
Celina Cavalcante Muniz Gomes
Post-traumatic stress disorder (PTSD) is a chronic and multifactorial psychiatric condition that is often underdiagnosed, particularly when associated with chronic diseases (CDs). These conditions arise from complex interactions among psych...
Association between Suicidal Ideation and Immune Parameters in Firstepisode Patients with Schizophrenia [0.03%]
首发精神分裂症患者自杀意念与免疫参数之间的相关性分析
Yu Xia,Xiaoni Guan,Meihong Xiu et al.
Yu Xia et al.
Introduction: Disturbed immunity and inflammation have been associated with the pathogenesis of schizophrenia (SZ) and suicidal behaviors. We hypothesized that the neutrophil-tolymphocyte ratio (NLR) was associated with t...
Mitochondria as a Therapeutic Target in Neurodegeneration: Strategies for Restoring Cellular Homeostasis [0.03%]
线粒体在神经退行性疾病治疗中的作用：恢复细胞稳态的策略
Bartosz Twarowski,Iwona Piątkowska-Chmiel,Mariola Herbet
Bartosz Twarowski
Ageing is a complex biological process marked by a gradual decline in bodily functions at the cellular, tissue, and organ levels, resulting from molecular damage and environmental influences. It increases disease risk, particularly in older...
The Cathepsin Family in Disease: From Molecular Mechanisms to Therapeutic Applications [0.03%]
丝裂酶家族在疾病中的作用：从分子机制到治疗应用
Lorca Alzoubi,Yassmen Hamzat,Alaa Alqudah et al.
Lorca Alzoubi et al.
The cathepsin family of proteolytic enzymes is involved in the maintenance of major physiological processes, including protein degradation, immune modulation, tissue remodeling, and apoptosis. Members of the cathepsin family include cystein...