Role of Perineuronal Nets in Neuronal Plasticity and Repair: Molecular Perspectives on Psychiatric Disorders [0.03%]
神经病理性网在神经可塑性和修复中的作用：精神病障碍的分子视角
Sami I Alzarea
Sami I Alzarea
Introduction: Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that wrap fast-spiking parvalbumin-positive (PV⁺) interneurons, which serve in supporting synaptic stability, ion channel modulation, and p...
Antidepressants for Child and Adolescent Depression: Evidence, Controversies, and Clinical Implications [0.03%]
儿童和青少年抑郁症的抗抑郁药物治疗：证据、争议及临床意义
Letian Di,Weidong Jin,Fengli Sun
Letian Di
The question of whether antidepressant medications are effective in treating depression among children and adolescents has long been a subject of intense discussion. Evidence-based medical research indicates that the efficacy of antidepress...
Parkinson's Disease, Gut Microbiota and Plasma Metabolites: Causal Pathways via a Mendelian Randomization Study [0.03%]
基于孟德尔随机化研究的帕金森病、肠道微生物群和血浆代谢物的因果途径
Guichun Gong,Yanran Qian,Xianjin Tang et al.
Guichun Gong et al.
Introduction: Mounting evidence implicates gut microbiota in PD pathogenesis, with emerging studies suggesting this influence may be mediated by plasma metabolites. However, the causal relationships between gut microbiota...
Nanomedicine Strategies for Overcoming Temozolomide Resistance in Glioblastoma [0.03%]
用于克服胶质母细胞瘤替莫唑胺耐药性的纳米医学策略
Yancheng Lv,Jiazu Sa,Ke Wang et al.
Yancheng Lv et al.
Background: Glioblastoma multiforme (GBM) is among the deadliest of brain tumors. While temozolomide (TMZ) is the standard treatment, tumors quickly develop resistance, leading to patient relapse. The blood-brain barrier ...
Junfei Yi,Zicheng Pang,Yuerong Wu et al.
Junfei Yi et al.
Objectives: The rapid expansion of therapeutic research in white matter diseases, particularly Multiple Sclerosis (MS), necessitates a structured analysis of the field. This study aimed to systematically map the knowledge...
Mitochondrial Regulatory Network: Multi-dimensional Pathological Mechanism of Ischemic Stroke and New Strategies for Targeted Therapy [0.03%]
线粒体调节网络在缺血性脑卒中发病机制及靶向治疗中的作用
Yecheng Wang,Jia Xiang,Songwen Tan
Yecheng Wang
Ischemic stroke is characterized by limited therapeutic options and a high rate of longterm disability. The majority of strokes are ischemic in nature and result from cerebral vascular occlusion, leading to substantial neurological damage a...
Single-cell Dissection of Microglial Heterogeneity Reveals Subtype-driven Immune-metabolic Crosstalk in Major Depressive Disorder [0.03%]
单细胞解析小胶质细胞异质性揭示抑郁障碍中的亚型驱动的免疫代谢相互作用
Qingqing Li,Yunfeng Wang,Le Ma et al.
Qingqing Li et al.
Introduction: Major Depressive Disorder (MDD) is linked to excitation-inhibition imbalance in prefrontal cortex (PFC) neural circuits, whose formation relies on communication between neurons and microglia. However, the me...
The AGE-RAGE-GLO1 Pathway in Glioma: A Systematic Review of Its Role in Tumour Biology and Therapy [0.03%]
胶质瘤中AGE-RAGE-GLO1通路的作用：其在肿瘤生物学和治疗中的作用系统评价
Evangelos Papadopoulos,Mary Solou,Ioannis Ydreos et al.
Evangelos Papadopoulos et al.
Background: Gliomas, particularly glioblastoma (GB), are aggressive brain tumours with poor prognosis and limited therapeutic options. Chronic oxidative stress and inflammation are central to glioma pathogenesis, driven i...
The Efficacy of Glucagon-like Peptide-1 Receptor Agonists on Different Cognitive Domains: A Meta-analysis of Randomized Controlled Trials [0.03%]
glucagon样肽-1受体激动剂对不同认知领域的影响：随机对照试验的meta分析
Hong Xu,Jing Zhang,Yuqing Wang et al.
Hong Xu et al.
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been widely studied for cognitive enhancement. However, their clinical efficacy remains inconclusive in patients with Alzheimer's disease (AD), Park...
The Role of Melatonin and Chronotherapy in the Treatment of Circadian Rhythm Disruption and Depression [0.03%]
褪黑素和时间疗法在节律紊乱和抑郁治疗中的作用
Yin Shen,Adeel Ahmed,Xiaoqin Fu et al.
Yin Shen et al.
The circadian rhythm is the body's natural timekeeper, determining when to sleep and wake over a 24-hour cycle. This biological clock can be reset by light and temperature, enabling body functions to align with the day-night cycle. Disrupti...