Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System [0.03%]
碳纳米结构的前沿方法：用于中枢神经系统的靶向药物输送
Venishaa S,Mridul Guleria,Prashant Kumar et al.
Venishaa S et al.
Drug delivery through the blood-brain barrier (BBB) is one of the key challenges in the modern era of medicine due to the highly semipermeable characteristics of BBB that restrict the entry of various drugs into the central nervous system (...
Comprehensive Review on Alzheimer's Disease: Natural Therapeutics, Gaps and Challenges [0.03%]
阿尔茨海默病的综合评论：天然治疗、差距和挑战
Prem Shankar Mishra,Rakhi Mishra,Anuj Kumar
Prem Shankar Mishra
More than 20 million people worldwide have Alzheimer's disease (AD), making it the most prevalent disease. Patients with AD may live for at least a decade after diagnosis, making it the most common cause of disability in the elderly. Each y...
The Smart Drug Delivery of Rotigotine Using Transdermal Patch for the Successful Management of Parkinson's Disease [0.03%]
罗替戈汀透皮贴剂的智能药物递送系统在帕金森病治疗中的成功应用研究
Jose Prakash Dharmian,Angelin Claret Seraphim PushpaNathan,Prakash Ramakrishnan et al.
Jose Prakash Dharmian et al.
Background: A Non-Ergot Dopamine Agonist (NEDA) rotigotine has been designed as a new transdermal drug delivery system. Aim: To maintai...
Sanidhya Jain,Avijit Mazumder,Saumya Das et al.
Sanidhya Jain et al.
Mild Cognitive Impairment (MCI) is swiftly emerging as a prevalent clinical concern within the elderly demographic. Willoughby spearheaded the pioneering investigation into the evolution of memory decline spanning from the age of 20 to 70. ...
Ramón Cacabelos
Ramón Cacabelos
Research on Alzheimer's Disease (AD) Involving the Use of In vivo and In vitro Models and Mechanisms [0.03%]
基于体内和体外模型与机制的阿尔茨海默病(AD)研究
Sweta Sinha,Pranay Wal,Prakash Goudanavar et al.
Sweta Sinha et al.
Background: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the progressive formation of extracellular amyloid plaques, intracellular neurofibrillary tangles, inflammation, and impaired antioxida...
Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and Associated Spatial Memory Impairments in Rats [0.03%]
神经完整性保护：NFκB在andrographolide的神经保护功效中的可能作用及其与氯化铝诱导的大鼠神经毒性和相关空间记忆损害的研究
Abhitinder Kumar,Mohit Agrawal,Yogesh Murti et al.
Abhitinder Kumar et al.
Objective: The current study was structured to evaluate the neuroprotective properties of andrographolide in the context of aluminum chloride (AlCl3)-induced neurotoxicity, along with its concurrent impact on spatial memo...
A Computational Study of Phenothiazine Derivatives as Acetylcholinesterase Inhibitors Targeting Alzheimer's Disease [0.03%]
苯并噻嗪衍生物作为乙酰胆碱酯酶抑制剂靶向阿尔茨海默病的计算研究
Prema V,Prema A,Prema N
Prema V
Background: Alzheimer's disease is a neurodegenerative disorder that affects learning, memory and behavioral turbulence in elderly patients. Acetylcholinesterase (AChE) inhibitors act as anti-Alzheimer's agents. Phenothia...
Inhibitory Role of L-theanine, a Structural Analogue of Glutamate, Against GluR5 Kainate Receptor and its Prospective Utility Against Excitotoxicity [0.03%]
L-茶氨酸作为 glutamate 结构类似物抑制 GluR5 天冬氨酸受体的作用以及其有望成为抗兴奋毒性物质的潜在用途研究
Satarupa Deb,Anupom Borah
Satarupa Deb
Background: Overactivation of receptors that respond to excitatory neurotransmitters can result in various harmful outcomes, such as the inability to properly modulate calcium levels, generation of free radicals, initiati...
Zahra Tolou-Ghamari
Zahra Tolou-Ghamari
Background: Seizures are a common presenting symptom of the central nervous system (CNS) and could occur from infections (such as toxins) or drugs. Object...