Marine-Derived Compounds: A Powerful Platform for the Treatment of Alzheimer's Disease [0.03%]
海洋衍生化合物：治疗阿尔茨海默病的强大平台
Rashmi Arora,Ritchu Babbar,Abhishek Dabra et al.
Rashmi Arora et al.
Alzheimer's disease (AD) is a debilitating form of dementia that primarily affects cholinergic neurons in the brain, significantly reducing an individual's capacity for learning and creative skills and ultimately resulting in an inability t...
Himanshi Varshney,Yasir Hasan Siddique
Himanshi Varshney
Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterized by the depletion of striatal dopamine content and aggregation of alphasynuclein in the substantia nigra (SN). It is possible to treat the sym...
Molecular Pathway, Epidemiological Data and Treatment Strategies of Fungal Infection (Mycoses): A Comprehensive Review [0.03%]
真菌感染（霉菌病）的分子通路，流行病学数据和治疗策略的综合审查
Namrata Singh,Vibha Kumari,Karan Agrawal et al.
Namrata Singh et al.
The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicine...
A Comprehensive Review on Potential Molecular Drug Targets for the Management of Alzheimer's Disease [0.03%]
阿尔茨海默病治疗的潜在分子药物靶点综述
Chanchal Sharma,Avijit Mazumder
Chanchal Sharma
Alzheimer's disease (AD) is an onset and incurable neurodegenerative disorder that has been linked to various genetic, environmental, and lifestyle factors. Recent research has revealed several potential targets for drug development, such a...
Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats [0.03%]
从Swertia chirayita叶中分离的芒果素对链脲佐菌诱导的大鼠糖尿病神经病变的抗氧化通路的神经保护作用
Shivam,Asheesh Kumar Gupta
Shivam
Background: Oxidative stress has an important role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complication of diabetes mellitus. Swertia chirayita is a ri...
Network Reorganization for Neurophysiological and Behavioral Recovery Following Stroke [0.03%]
中风后为了神经生理和行为恢复的网络重组
Yuan Qi,Yujie Xu,Huailu Wang et al.
Yuan Qi et al.
Stroke continues to be the main cause of motor disability worldwide. While it has been promised to improve recovery after stroke, efficacy in clinical trials has been mixed. We need to understand the cortical recombination framework to unde...
Lead Identification Through In Silico Studies: Targeting Acetylcholinesterase Enzyme Against Alzheimer's Disease [0.03%]
通过计算机模拟研究识别先导物：针对乙酰胆碱酯酶以对抗阿尔茨海默病
Dhairiya Agarwal,Sumit Kumar,Ramesh Ambatwar et al.
Dhairiya Agarwal et al.
Aim: In this work, we aimed to acquire the best potential small molecule for Alzheimer's disease (AD) treatment using different models in Biovia Discovery Studio to identify new potential inhibitors of acetylcholinesteras...
Purple Carrot Extract Exhibits A Neuroprotective Profile In The Nigrostriatal Pathway In The Reserpine-Induced Model Of Parkinson's Disease [0.03%]
紫胡萝卜提取物在蛇根碱诱导的帕金森病模型中的黑质纹状体通路中具有神经保护作用
Ana Claudia Custódio-Silva,Jose Ivo Araújo Beserra-Filho,Beatriz Soares-Silva et al.
Ana Claudia Custódio-Silva et al.
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the nigrostriatal pathway. Even with scientific and technological advances, the...
Sulfonamide Derivatives: Recent Compounds with Potent Anti-alzheimer's Disease Activity [0.03%]
磺胺衍生物：近期具有强力抗阿尔茨海默病作用的化合物
Melford Chuka Egbujor
Melford Chuka Egbujor
Facile synthetic procedures and broad spectrum of biological activities are special attributes of sulfonamides. Sulfonamide derivatives have demonstrated potential as a class of compounds for the treatment of Alzheimer's disease (AD). Recen...
Glutamate Receptors and C-ABL Inhibitors: A New Therapeutic Approach for Parkinson's Disease [0.03%]
谷氨酸受体和C-ABL抑制剂：治疗帕金森病的新方法
Priya P Shejul,Gaurav M Doshi
Priya P Shejul
Parkinson's disease (PD) is the second-most prevalent central nervous system (CNS) neurodegenerative condition. Over the past few decades, suppression of BCR-Abelson tyrosine kinase (c-Abl), which serves as a marker of -synuclein aggregatio...