Contribution of MEK1/ERK1/2/iNOS pathway to oxidative stress and decreased caspase-3 activity in endotoxemic rats [0.03%]
MEK1/ERK1/2/iNOS信号转导途径参与内毒素血症大鼠氧化应激及Caspase-3活性下降的作用机制研究
Belma Korkmaz,Tuba Cuez,C Kemal Buharalioglu et al.
Belma Korkmaz et al.
Oxidative stress and apoptosis are the states that can contribute to the pathogenesis of sepsis. In this study we aimed to investigate whether mitogen-activated protein kinase kinase 1 (MEK1)/extracellular signal-regulated kinase 1/2 (ERK1/...
Increased production of nitric oxide mediates selective organ-specific effects of endotoxin on oxidative stress [0.03%]
一氧化氮产生的增加介导内毒素对各器官选择性氧化压力的影响
Seyhan Sahan-Firat,Necmiye Canacankatan,Belma Korkmaz et al.
Seyhan Sahan-Firat et al.
Endotoxemic shock is a systemic inflammatory response that is associated with increased nitric oxide (NO) production by inducible NO synthase (iNOS) which contributes to hypotension, vascular hyporeactivity, and multiple organ failure. Oxid...
Fusun Kalpaklioglu,Ayse Baccioglu
Fusun Kalpaklioglu
H1-antihistamines are inverse agonists that combine with and stabilize inactive conformation of H1-receptors. Thus they interfere with actions of histamine at H1-receptors. They are widely used for treatment of allergic rhinitis, allergic c...
Apoptotic and anti-angiogenic effects of benzimidazole compounds: relationship with oxidative stress mediated ischemia/reperfusion injury in rat hind limb [0.03%]
苯并咪唑化合物的凋亡和抗血管生成作用及其与氧化应激介导的缺血/再灌注损伤的关系研究
Oztekin Algul,Alper Karabulut,Necmiye Canacankatan et al.
Oztekin Algul et al.
Ischemia/reperfusion (I/R)-induced injury is a pathophysiological process consisting of a complex cascade characterized by an increase in reactive oxygen species production, pro-inflammatory cytokine release, and activated endothelial cells...
A new method for a quantitative determination of piroxicam in pharmaceutical formulations using FT-IR spectrometry [0.03%]
一种新的定量测定药物剂型中吡罗昔康含量的方法——傅里叶变换红外光谱法
Andrei A Bunaciu,Şerban Fleschin,Hassan Y Aboul-Enein
Andrei A Bunaciu
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by...
Alteration of cholinergic system in keratinocytes cells produces acantholysis: a possible use of cholinergic drugs in pemphigus vulgaris [0.03%]
角蛋白细胞中胆碱能系统的改变产生棘松解：胆碱能药物在寻常型天疱疮中的潜在应用
Luca Fania,Anna Zampetti,Giuseppe Guerriero et al.
Luca Fania et al.
Human epidermis shows a non-neuronal cholinergic system including keratinocyte (kc) acetylcholine (Ach) axis which is composed by enzymes and two families of Ach receptors (muscarinic and nicotinic receptors). The activity of these two rece...
Interleukin-26, a highly cationic T-cell cytokine targeting epithelial cells [0.03%]
一种新的T细胞细胞因子白细胞介素26：高度阳离子化和靶向上皮细胞作用特点
Oliver Braum,Heide Pirzer,Helmut Fickenscher
Oliver Braum
Interleukin-26 (IL-26) is a member of the IL-10 cytokine family due to sequence homology. IL-26 was discovered, since the gene is strongly overexpressed in T cells which are growth transformed by herpesvirus saimiri. The IL-26 gene maps to ...
Bahar Tunctan
Bahar Tunctan
Does inhaled corticosteroid treatment result in a secondary immune deficiency predisposing to recurrent infections? [0.03%]
吸入皮质激素治疗会导致继发性免疫缺陷和反复感染吗？
Nerin N Bahceciler
Nerin N Bahceciler
It is well known that long-term treatment with systemic steroids exerts immune-suppressive effects on the cellular immune system and increase the susceptibility to all types of intracellular infections. Inhaled corticosteroids have been the...
Success of inhaled corticosteroids in the treatment of non-asthmatic respiratory diseases [0.03%]
吸入皮质类固醇在非哮喘性呼吸道疾病治疗中的应用进展
Nazan Cobanoglu
Nazan Cobanoglu
Systemic corticosteroids (SCSs) have been widely used to treat various inflammatory respiratory diseases for many years despite the serious complications associated with them. Inhaled corticosteroids (ICSs) have been developed to reduce the...