Neutrophil F-actin dynamics in Familial Mediterranean Fever: the unequal effect of colchicine on activated neutrophils [0.03%]
美籍地中海发热患者的中性粒细胞F-actin动态变化：秋水仙碱对激活的中性粒细胞的作用不平等效应
Tigran K Davtyan,Samvel A Avetisyan,Gagik S Hakobyan
Tigran K Davtyan
In the innate immune system, cellular adaptation regulates neutrophil activation and chemotaxis, which have a pivotal role in Familial Mediterranean Fever (FMF) pathogenesis. We investigated neutrophil F-actin, phagocytosis and macropinocyt...
On the cellular and molecular regulatory transcriptional mechanisms and responsive putative pathways to inflammatory oxidative stress revisited: current immunological breakthroughs and views at a glance [0.03%]
重温炎症氧化应激的细胞和分子调控转录机制及其响应途径：当前免疫学进展概览
John J Haddad
John J Haddad
Responses to oxidative stress are generally regulated by redox-responsive transcription factors (TFs). The abrupt variation in the partial pressure of oxygen (pO2) constitutes a regulatory mechanism. Such TFs forming an integral part of tho...
Cholinergic drugs as therapeutic tools in inflammatory diseases: participation of neuronal and non-neuronal cholinergic systems [0.03%]
胆碱能药物在炎症性疾病治疗中的作用：神经和非神经胆碱能系统的参与
María Elena Sales
María Elena Sales
Acetylcholine (ACh) is synthesized by choline acetyltransferase (ChAT) from acetylcoenzime A and choline. This reaction occurs not only in pre-ganglionic fibers of the autonomic nervous system and post-ganglionic parasympathetic nervous fib...
Medha Priyadarshini,N A Arivarasu,Aaliya Shah et al.
Medha Priyadarshini et al.
MicroRNAs (miRNAs) have emerged as key gene regulators controlling the expression of many target mRNAs. The nervous system harbors highest number of miRNAs expressed in a spatially and temporally controlled manner. Neural miRNAs have been a...
Molecular interaction study of N1-p-fluorobenzyl-cymserine with TNF-α , p38 kinase and JNK kinase [0.03%]
N1-p-氟苯甲酰-cymserine与TNF-α、p38激酶和JNK激酶分子间相互作用研究
Sidra Batool,Muhammad Sulaman Nawaz,Nigel H Greig et al.
Sidra Batool et al.
Alzheimer's disease (AD) is an age-related neurodegenerative disease distinguished by progressive memory loss and cognitive decline. It is accompanied by classical neuropathological changes, including cerebral deposits of amyloid- beta pept...
Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action [0.03%]
帕金森药物Posiphen的合成及其主要代谢产物(+)-N1-norPosiphen、(+)-N8-norPosiphen和(+)-N1， N8-双羟基无环Posiphen对淀粉样蛋白前体蛋白、α-突触核蛋白合成、白细胞介素-1β释放及胆碱能作用的抑制作用
Qian-Sheng Yu,Marcella Reale,Mohammad A Kamal et al.
Qian-Sheng Yu et al.
A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of senile plaques that are primarily composed of aggregated forms of β-amyloid peptide (Aβ) that derive from amyloid precursor protein (APP). Posiphen ...
Editorial (hot topic:modulation of cholinergic system activity in neuronal and non-neuronal tissues: therapeutic implications) [0.03%]
主编点评(热点专题：胆碱能系统在神经和非神经组织中的调节作用：治疗意义)
Marcella Reale,Ada Maria Tata
Marcella Reale
François Roubille,Jean-Claude Tardif
François Roubille
Camille Roubille,Johanne Martel-Pelletier,Jean-Marc Davy et al.
Camille Roubille et al.
Anti-inflammatory drugs consist of non-steroidal anti-inflammatory drugs (NSAIDs) including non-selective nsNSAIDs, aspirin, and cyclooxygenase-2 (COX-2)-selective inhibitors also referred to as coxibs, and glucocorticoids (GCs). They are w...