G Fenu,L Lorefice,F Frau et al.
G Fenu et al.
Multiple sclerosis (MS) is a chronic demyelinating disease affecting the central nervous system. Pharmacological therapy of MS includes symptomatic drugs, treatment for relapses (corticosteroid and intravenous immunoglobulin) and disease mo...
L Lorefice,G Fenu,J Frau et al.
L Lorefice et al.
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system. Disease-modifying drugs licensed for MS treatment have been developed to reduce relapse rates and halt disease progression. The majority of current MS dr...
Development of montelukast sodium loaded niosomal carriers by film hydration technique [0.03%]
薄膜水化法制备孟鲁司特钠尼osome载药体系及其评价
Sumit Kumar,Rajendra Awasthi
Sumit Kumar
The aim of this study was to develop and characterize montelukast sodium loaded niosomal drug carrier systems. The vesicles were prepared by film hydration technique using different surfactants. The optimized formulation was selected on the...
Assessments of Immunomodulatory and Inflammatory effects against Induction of Entamoeba histolytica (HM1 IMS strain) crude extract Antigen in Complete Freund's Adjuvant Induced Rheumatoid Arthritis Female Wistar Rats [0.03%]
评估免疫调节和抗炎作用：完全弗氏佐剂诱导的大鼠类风湿关节炎模型中溶组织内阿米巴（HM1 IMS株）粗提物抗原的诱导效应
Swati Bagde,Vinod Singh
Swati Bagde
Today it is well known about mechanisms of cell communication, how the cells that mediate immune response and tissue injury accumulate in tissues but the aetiology of rheumatoid arthritis (RA) is still unknown. This study was to evaluate im...
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents [0.03%]
设计和合成用作止痛剂的苯并咪唑衍生物曼尼希碱的研究
Prasanna A Datar,Saleel A Limaye
Prasanna A Datar
Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activ...
Synthesis and in vitro Evaluation of Polymeric Prodrug of Ibuprofen with Amino Acid Spacer [0.03%]
含氨基酸间隔基的布洛芬聚丙烯酸酯前药的合成及体外评价研究
Vivekkumar K Redasani,Sanjay B Bari
Vivekkumar K Redasani
The present work is an agreement with simple and efficient method of improving the therapeutic efficacy of ibuprofen by masking its acidic moiety. It aims to reduce gastrointestinal side effects by controlling the rate, duration and site of...
Pharmacological Potential of Tetrahydrofurano/Pyrano Quinoline and Benzo[b]furoindolyl Derivatives in Acute Inflammation, Pain and Oxidative Stress [0.03%]
四氢呋喃/吡喃喹啉和苯并bfuroindolyl衍生物在急性炎症，疼痛和氧化应激中的药理潜力
B C Goudarshivananavar,V Vigneshwaran,Kattepura K Dharmappa et al.
B C Goudarshivananavar et al.
Objective: Investigation of the pharmacological potential of Tetrahydrofurano/pyrano quinoline and Benzo [b]furoindolyl derivatives in acute inflammation, pain and oxidative stress. ...
Ilona J Kosten,Thomas Rustemeyer
Ilona J Kosten
The idea of regulatory T cells (Tregs) lost its popularity during the 1980s and 1990s, since immunologists failed to elucidate how the innate regulation of immunological reactions worked. The entire re-evaluation of the Tregs was supported ...
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs [0.03%]
依托度酸前药的合成、水解动力学及其药理评价研究
Bharat V Dhokchawle,Anil B Bhandari
Bharat V Dhokchawle
The mutual prodrugs of aceclofenac with various naturally available antioxidants; menthol, thymol, eugenol, guiacol and vanillin have been synthesized by the DCC coupling method, purified and characterized by spectral data, as well as, part...