Triazol-phenyl Antipyretic Derivatives Inhibit mPGES-1 mRNA Levels in LPS-Induced RAW 264.7 Macrophage Cells [0.03%]
三氮唑类抗炎退热衍生物通过抑制LPS诱导的RAW 264.7巨噬细胞中mPGES-1 mRNA水平表达发挥作用
Lenisa Dandara Dos Santos,Thamires Quadros Froes,Miriam Cristina Contin de Melo et al.
Lenisa Dandara Dos Santos et al.
Background: Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step of prostaglandin E2 (PGE2) production, which plays an important role in the regulation of febrile response. In our previous work, lig...
Anti-Inflammatory, Antimicrobial and Insecticidal Properties of Daucus Gracilis Steinh Flowers Essential Oil [0.03%]
Daucus gracilis steinh 花精油的抗炎、抗菌及杀虫作用
Bouhassane Nadia,Nouria Merad-Boussalah,Fatima Benyoucef et al.
Bouhassane Nadia et al.
Background: Daucus gracilis Steinh belongs to the Apiaceae family. The flowers of this plant have been used by the population of western Algeria for the treatment of mouth ulcers. However, very few studies exist concernin...
Amal A Mohamed,Omnia I Tantawi,Lamiaa A Fathalla et al.
Amal A Mohamed et al.
Novel Corona Virus 2019 (COVID-19) is a new virus spread rapidly all over the world. It has specific respiratory or gastrointestinal tract symptoms. Its reported complications include respiratory distress, systemic inflammatory response syn...
Synthesis of Novel Aryl (4-Aryl-1H-Pyrrol-3-yl) (Thiophen-2-yl) Methanone Derivatives: Molecular Modelling, In Silico ADMET, Anti-Inflammatory and Anti-Ulcer Activities [0.03%]
新型芳基(4-芳基-1h-吡咯-3-基)(噻吩-2-基)甲酮衍生物的合成：分子模拟、 ADMET 虚拟筛选及其抗炎和抗溃疡活性
Arif Pasha,Sumanta Mondal,Naresh Panigrahi
Arif Pasha
Background: Due to the presence of both five-membered heterocyclics like pyrrole and thiophene in one molecule considerable attention was made for their enormous pharmacological activities out of which include anti-inflam...
Peripheral Anti-nociceptive and Anti-inflammatory Effect of Oleanolic Acid in a Rat Model of Osteoarthritis [0.03%]
熊果酸对骨关节炎大鼠模型外周抗痛觉过敏和抗炎作用
Israa Salman,Marc Fakhoury,Malak Fouani et al.
Israa Salman et al.
Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechan...
In-silico Prediction of the Beta-carboline Alkaloids Harmine and Harmaline as Potent Drug Candidates for the Treatment of Parkinson's disease [0.03%]
harmine和harmlaine的计算机预测：β-碳啉生物碱作为治疗帕金森病的有效药物候选物
Rumpa Banerjee,Mukesh Kumar,Isha Gaurav et al.
Rumpa Banerjee et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disease manifested by core symptoms of loss of motor control and postural instability. Loss of dopaminergic neurons is the cause of PD, thus enhancin...
Common Issues Among Asthma, Epilepsy, and Schizophrenia: From Inflammation to Ca2+/cAMP Signalling [0.03%]
哮喘、癫痫与精神分裂症的共通问题：从炎症到钙离子/cAMP信号传导
Leandro Bueno Bergantin
Leandro Bueno Bergantin
Background: A large amount of evidence has described that asthma may be associated with a high epilepsy risk, and epilepsy may be linked with high asthma risk, especially among children and individuals in their 30s. Curio...
Modulation of Proinflammatory Bacteria- and Lipid-Coupled Intracellular Signaling Pathways in a Transwell Triple Co-Culture Model by Commensal Bifidobacterium Animalis R101-8 [0.03%]
益生元双歧杆菌R101-8调节共培养体系中促炎细菌和脂质偶联的细胞内信号通路
Darab Ghadimi,Annegret Nielsen,Mohamed Farghaly Yoness Hassan et al.
Darab Ghadimi et al.
Background and aims: Following a fat-rich diet, alterations in gut microbiota contribute to enhanced gut permeability, metabolic endotoxemia, and low grade inflammation-associated metabolic disorders. To better understand...
In Silico and In Vitro Studies of the Inhibitory Effect of Antihistamine Drug Cyproheptadine Hydrochloride on Human Salivary Alpha Amylase [0.03%]
抗组胺药盐酸西普拉堤定对人类唾液淀粉酶抑制作用的虚拟和离体研究
Benguechoua Madjda,Benarous Khedidja,Nia Samira et al.
Benguechoua Madjda et al.
Background: For the first time, the inhibitory effects on the human salivary alpha-amylase activity of the anti-inflammatory drugs indomethacin, diclofenac sodium, ketoprofen, diclofenac potassium, diclofenac, triamcinolo...
Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents [0.03%]
齐墩果酸-氮杂前列腺素类似物：作为抗炎剂的合成和药理评估
Tatyana S Khlebnicova,Yuri A Piven,Fedor A Lakhvich et al.
Tatyana S Khlebnicova et al.
Background: Prevention and treatment of chronic inflammatory diseases require effective and low-toxic medicines. Molecular hybridization is an effective strategy to enhance the biological activity of new compounds. Triter...