Sulfonamides as Aromatase Inhibitors: Nimesulide Analogues, N-cyclic- and Aryl-Sulfonamides [0.03%]
磺酰胺类芳香化酶抑制剂：尼美舒利类似物，N-环状和芳基磺酰胺
Cristina Maccallini,Alessandra Ammazzalorso,Barbara De Filippis et al.
Cristina Maccallini et al.
Aromatase catalyzes the final and rate-limiting step in the biosynthesis of estrogens. Inhibitors of this key enzyme are used to treat hormone receptor-positive early, locally advanced, and metastatic breast cancers and are classified by st...
Oleuropein and Colorectal Cancer Chemoprevention: Recent Advances into Cellular and Molecular Mechanisms [0.03%]
橄榄苦苷与结直肠癌的化学预防：细胞和分子机制的新进展
Gaetano Leto
Gaetano Leto
A growing number of epidemiological studies provide strong evidence regarding the significant association between Olive Oil (OO) consumption and reduced risk of colorectal cancer (CRC). The chemopreventive effects of OO on CRC growth and pr...
Anthracycline Drugs: An Update on Chemistry, Structure-Activity Relationship, Mechanism of Action, Cardiotoxicity, Physicochemical and Pharmacokinetic Properties [0.03%]
蒽环类药物：化学、构效关系、作用机制、心脏毒性及理化和药代动力学性质的最新进展
Yaser Pashaei,Necla Kulabaş,Sevil Şenkardeş
Yaser Pashaei
Objective: This review aims to examine the literature on FDA-approved anthracyclines, focusing on their physicochemical and pharmacokinetic properties, and to analyze relevant studies for insights into chemistry, structur...
Research Progress on Desmoid Tumors: New Perspectives from Molecular Mechanisms to Clinical Management [0.03%]
侵袭性纤维瘤病的发病机制及临床研究进展从分子机制到临床管理的新视角
Guizhen Lyu,Yuxin Zhang,Dongbing Li
Guizhen Lyu
Desmoid Tumors (DT) are rare fibromatoses that are locally invasive. These are described as being monoclonal, and they tend to recur. Their clinical features are also different, and the prognoses of these tumors are not predictable. The rec...
Phytochemical Insights and Anticancer Potential of Solanum americanum Mill: A Multi-Omics Perspective [0.03%]
基于多组学的Solanum americanum Mill植物化学成分及抗癌潜力研究新见解
Pawan Kumar Goswami,Sonakshi Antal,Ranjeet Kumar et al.
Pawan Kumar Goswami et al.
Introduction: Solanum americanum Mill is a medicinal plant, which is used in the traditional systems of medicine in Ayurveda, African, Pacific Islander, and Native American for treating fever, liver disorders, inflammatio...
Prognostic Value of Lactate Metabolism-Related Gene Signatures in Cancer Cells [0.03%]
癌症细胞中乳酸代谢相关基因特征的预后价值
Reza Mosaddeghi-Heris,Seyyed Sina Hejazian,Hanie Karimi et al.
Reza Mosaddeghi-Heris et al.
Introduction: Predicting prognosis in cancer is complex. While traditional staging methods are useful, they do not fully account for the unique biology of each tumor. There is a growing need for biomarkers that capture th...
ATP5B Expression as a Prognostic Biomarker in Solid Tumors: A Systematic Review and Meta-Analysis [0.03%]
ATP5B在实体瘤中的预后价值及其作用机制：系统评价和Meta分析
Shimeng Li,Lu Qiao,Boyao Sun et al.
Shimeng Li et al.
Introduction/objective: Mitochondrial ATP synthase F1 subunit beta (ATP5B) is involved in the catalytic process of oxidative phosphorylation (OXPHOS). However, the prognostic value of ATP5B remains conflicting. Therefore,...
Natural Products for Overcoming EGFR-TKI Resistance in NSCLC: A Narrative Review [0.03%]
克服EGFR-TKI耐药的NSCLC的天然药物：叙述性综述
Zhenzhen Guo,Yufei Ma,Changjiang Guo et al.
Zhenzhen Guo et al.
Introduction: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has transformed the treatment of non-small cell lung cancer (NSCLC), yet acquired resistance remains a major challenge to its clinical ef...
Dharmendra Kumar,Kajal Goyal,Pramod Kumar Sharma
Dharmendra Kumar
Introduction: Marine ecosystems provide an abundant reservoir of structurally diverse natural compounds that exhibit distinctive pharmacological activities. In recent decades, many bioactive molecules isolated from marine...
Targeting XBP1 in Cancer: A Review of Therapeutic Approaches and Strategies [0.03%]
针对XBP1在癌症治疗中的作用：治疗手段和策略综述
Abdolah Mousavi Salehi,Ali Khavanin,Shirin Azizidoost et al.
Abdolah Mousavi Salehi et al.
X-box binding protein 1 (XBP1) is an essential unfolded protein response (UPR) transcription factor that has important roles in cancer biology. Malignant XBP1 signaling promotes tumor survival, drug resistance, and immune evasion and thus r...