Targeting XBP1 in Cancer: A Review of Therapeutic Approaches and Strategies [0.03%]
针对XBP1在癌症治疗中的作用：治疗手段和策略综述
Abdolah Mousavi Salehi,Ali Khavanin,Shirin Azizidoost et al.
Abdolah Mousavi Salehi et al.
X-box binding protein 1 (XBP1) is an essential unfolded protein response (UPR) transcription factor that has important roles in cancer biology. Malignant XBP1 signaling promotes tumor survival, drug resistance, and immune evasion and thus r...
Study on the Mechanism of Post-Chemotherapy Metastasis in Breast Cancer Based on Metabolomics and Development of TCM Metabolic Regulators [0.03%]
基于代谢组学的乳腺癌化疗后转移机制研究及抗肿瘤转移中药代谢调控剂的开发
Zhe Yu,Weiqi Wang,Junjie Tao et al.
Zhe Yu et al.
Introduction: Breast cancer (BC) is a leading global malignancy in women. Although central to treatment, chemotherapy may paradoxically promote metastasis. The role of metabolic changes in chemotherapy- induced metastasis...
Medicinal Chemistry of Natural Anti-Skin Cancer Agents: An Evidence-Based Literature Review [0.03%]
基于文献的天然抗皮肤药物活性成分机制研究综述
Mirna Al-Hasan,Abdullah Al Lawati,Maather Al Shuhaibi et al.
Mirna Al-Hasan et al.
Globally, the incidence and prevalence of skin cancer have increased. Skin cancers involve an abnormal growth of cells. Skin cancers are classified into melanoma and nonmelanoma skin cancer (NMSC), and NMSC is further classified as squamous...
Comparative Prognosis of HER2-Low versus HER2-Negative Breast Cancer: A Meta-Analysis [0.03%]
HER2低阳性与HER2阴性乳腺癌预后比较的meta分析
Yuanyuan Li,Tao Chen,Chuangang Tang et al.
Yuanyuan Li et al.
With the emergence of new antibody-drug conjugates (ADCs), low human epidermal growth factor receptor (HER2) expression may become a novel treatment target. However, despite the clinical trials of new ADCs, strong evidence to prove the prac...
Taraxasterol Suppresses Renal Cell Carcinoma Progression by Modulating Cell Cycle Progression and Apoptosis [0.03%]
大黄素通过调节细胞周期和凋亡抑制肾细胞癌的发展
Jiao-Gui Xie,Xing-Chen Liu,Xin-Wei Han et al.
Jiao-Gui Xie et al.
Renal cell carcinoma (RCC) is a common and aggressive urological malignancy with limited response to chemotherapy and radiotherapy. The search for effective, low-toxicity natural compounds is therefore of increasing interest. Taraxasterol (...
Theranostic Potential of [177Lu]Lu-DOTA-Tocilizumab in Multiple Myeloma: A Preclinical Evaluation [0.03%]
镥-177标记的DOTA-Tocilizumab在多发性骨髓瘤中的诊疗潜力：一项前期评估研究
Ximena Camacho,Mirel Cabrera,Carolina Perroni et al.
Ximena Camacho et al.
Multiple Myeloma (MM) is a haematological malignancy in which Interleukin-6 (IL-6) plays a crucial role in its growth and spread. The monoclonal antibody Tocilizumab binds strongly to IL-6 receptors, inhibiting their function. Our aim is to...
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A Systematic Review of In Vitro, In Vivo, and In Silico Studies [0.03%]
青蒿素及其衍生物通过促进铁死亡在癌症治疗中的作用：体外、体内和基于计算机的系统综述研究
Suheda Rumeysa Osmanlioglu Dag,Iffet Irem Tatli Cankaya,Ayse Mine Gencler Ozkan
Suheda Rumeysa Osmanlioglu Dag
Artemisinin (ART), a sesquiterpene lactone derived from Artemisia annua L., and its semisynthetic derivatives such as dihydroartemisinin (DHA) and artesunate (ARTE) have gained significant attention for their anticancer potential beyond the...
Thiourea Derivatives for the Potential Treatment of Lung Cancer via the Inhibition of EGFR and Efflux Pumps: Synthesis, In Silico, and In Vitro Studies [0.03%]
通过EGFR和外排泵抑制作用治疗肺癌的硫脲衍生物的合成、分子模拟及体外研究
Rania Abu-Zaid,Osama H Abusara,Buthaina Hussein et al.
Rania Abu-Zaid et al.
Introduction: The overexpression and/or mutations of Epidermal Growth Factor Receptor (EGFR) are associated with the progression of several cancers. Thiourea derivatives have emerged as promising compounds to target EGFR ...
Apoptotic and Anti-Proliferative Potential of Spirulina platensis Methanolic Extract Against the Human Breast Cancer Cell Line MDA-MB-231: A Step Towards Functional Cancer Therapy [0.03%]
螺旋藻甲醇提取物诱导人乳腺癌MDA-MB-231细胞凋亡和抗增殖的潜力：向功能性癌症治疗迈进的一小步
Aditi Srivastava,Zeba Siddiqi,Sahabjada Siddiqui et al.
Aditi Srivastava et al.
Introduction: Algae have garnered increasing interest in the fields of medicine and nutrition as a source of nutritious and non-toxic healthcare supplements. Spirulina platensis (SP), a microalga and a welldocumented nutr...
Guy Awad,Marc Boutros,Antoine Chartouni et al.
Guy Awad et al.
Introduction: Osteosarcoma remains the most common primary malignant bone tumor, with poor outcomes in metastatic or recurrent cases. Current treatments often fail to prevent relapse, highlighting the need for innovative ...