Emrelis for c-Met Positive NSCLC: A Breakthrough in Antibody-Drug Conjugate-based Treatment Approved by the FDA [0.03%]
FDA批准的针对c-Met阳性NSCLC的抗体偶联药物 Emvarlis取得突破性进展
Sayan Samui,Aman Kumar,Preeti Patel et al.
Sayan Samui et al.
Telisotuzumab Vedotin (Teliso-V), previously known as ABBV-399, is a novel, first-in-class antibodydrug conjugate developed by AbbVie. It combines an anti-c-Met monoclonal antibody (ABT-700) with monomethyl auristatin E (MMAE), a potent mic...
Lazertinib: A Selective EGFR Mutant Inhibitor to Treat Non-Small Cell Lung Cancer [0.03%]
拉泽替尼：用于治疗非小细胞肺癌的高效选择性表皮生长因子受体突变抑制剂
Hyma Mandapaka,Surya Kanta De
Hyma Mandapaka
One of the leading causes of death related to cancer worldwide is non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutations are one of the most important therapeutic targets. Lazertinib is an irreversible EGFR ty...
Himanshu Singh,Rajnish Kumar,Avijit Mazumder et al.
Himanshu Singh et al.
Introduction: The evolution of resistance to different types of cancer therapies has become a significant challenge in oncology research, leading to disease progression and limited treatment options. Rechallenge therapy, ...
Miao-Xia Pu,Wen-Bo Xu,Li Ding et al.
Miao-Xia Pu et al.
Introduction: CDK4/6 kinases are crucial cell cycle regulators, and pharmacological inhibition of these kinases to block the G1-to-S phase transition has become an integral part of modern cancer therapy. Although five CDK...
CD147 Is Involved in Tanshinone IIA-Induced Reprogramming of the Warburg Effect in Prostate Cancer Cells [0.03%]
红花黄色素诱导前列腺癌细胞重编程瓦博格效应相关机制研究
Yunye Wang,Jierui Zhao,Shutong Chen et al.
Yunye Wang et al.
Introduction: Cancer cells exhibit metabolic characteristics known as the Warburg effect, which is aerobic glycolysis. Tan IIA, a compound from Salvia miltiorrhiza, has antitumor effects, but its impact on prostate cancer...
Efficacy and Safety of HAIC Plus Regorafenib and Icaritin in Advanced Hepatocellular Carcinoma After First-Line Lenvatinib Failure: A Retrospective Analysis [0.03%]
替雷利珠单抗联合阿帕替尼和安罗替尼治疗既往未经或经其他免疫检查点抑制剂治疗的复发/转移性鼻咽癌的疗效及安全性：Ⅱ期研究
Haohao Lu,Ya Gao,Bin Liang et al.
Haohao Lu et al.
Introduction: We evaluated the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with regorafenib and icaritin in patients with advanced hepatocellular carcinoma (HCC) progressing after first-l...
Expanding the Horizon of CAR-T Cell Therapy: Present Obstacles and New Strategies for Future CARs in Solid Tumors [0.03%]
CAR-T细胞治疗的前景、现状及固体瘤新策略展望
Qasim Javed,Shoaib Majeed,Adnan Shahid et al.
Qasim Javed et al.
Chimeric antigen receptor (CAR)-T cells are synthetic receptors used for the recognition of specific antigens expressed by reprogrammed T cells for targeting tumors. CAR-T cell therapy has gained remarkable clinical success for the treatmen...
Comparative Efficacy of Poly-ADP-Ribose Polymerase Inhibitors (Parpis) in the Treatment of Advanced Ovarian Cancer in Younger and Elderly Patients: A Systematic Review and Meta-Analysis [0.03%]
PARPis用于年轻及老年晚期卵巢癌患者治疗的比较疗效：系统评价和Meta分析
Yujie Feng,Ying Zhang,Juanjuan Hu et al.
Yujie Feng et al.
Introduction: To compare the efficacy of PARPIs in younger and elderly patients with advanced ovarian cancer. Methodology: This meta-an...
Nanotechnology-Empowered Photodynamic Therapy for Improved Oral Cancer Treatment [0.03%]
用于改善口腔癌治疗的纳米技术光动力疗法
Venkateshwaran Krishnaswami,Selvakumar Muruganantham,Jacob Raja et al.
Venkateshwaran Krishnaswami et al.
Background: Oral cancer is the most prevalent type of head and neck cancer, usually affecting those 60 years of age and older. Oral cancer affects the lips and the first few sections of the tongue. Oral cancer has the pot...
Design, Synthesis, Spectroscopic Analysis, and In Silico Molecular Docking Study of Novel Azo Compounds as Potential Antioxidant and Anti-Triple-Negative Breast Cancer Agents [0.03%]
新型偶氮化合物作为抗氧化和抗三阴性乳腺癌剂的设计、合成、光谱分析及分子对接研究
Zainab Y Kadhim,Hasanain Gomhor J Alqaraghuli,Ali Y Naoom et al.
Zainab Y Kadhim et al.
Introduction: The aim of this study was to synthesize novel bioactive azo compounds and investigate their anti-triple-negative breast cancer and antioxidant properties using in vitro and in silico approaches. ...