Decoding Sarcoma Drug Resistance: From Molecular Mechanisms to Precision Interventions [0.03%]
解码肉瘤药物抗性：从分子机制到精准干预
Guizhen Lyu,Dongbing Li
Guizhen Lyu
Introduction: This study aims to systematically synthesize current knowledge on the molecular and microenvironmental mechanisms driving sarcoma drug resistance, and to evaluate emerging precision strategies for overcoming...
Glycyrrhetinic Acid in Cancer Therapy: Mechanistic Insights, Therapeutic Potential, and Future Directions [0.03%]
甘草酸在癌症治疗中的机制见解、治疗潜力和未来方向
Nilufar Yoqubova,Shokhid Gulyamov,Doniyorbek Abdulla-Zoda et al.
Nilufar Yoqubova et al.
Cancer presents a significant and growing global health challenge in the 21st century, marked by a rising number of new diagnoses and cancer-related deaths reported annually. Glycyrrhetinic Acid (GA), a triterpenoid compound derived from th...
Oxygen Free Radicals and Cancer: Protective Role of Endogenous Antioxidants and Natural Compounds [0.03%]
氧自由基与癌症：内源性抗氧化剂和天然化合物的保护作用
Zainab Irfan,Sayed Mohammad Firdous,Sumon Giri et al.
Zainab Irfan et al.
Introduction: Reactive oxygen species (ROS) are highly reactive oxygen-derived molecules that function as both potent inducers of cellular damage and essential signalling mediators. In a physiological setting, normal ROS ...
A Preliminary Study on Photodynamic Therapy for Central Tracheobronchial Malignant Tumours [0.03%]
光动力疗法治疗中心型气道恶性肿瘤的初步研究
Beilei Gong,Yongyan Zhang,Ting Wang et al.
Beilei Gong et al.
Introduction: Photodynamic therapy (PDT) holds considerable potential in inoperable central tracheobronchial malignant tumours. However, evidence is scarce from Chinese populations. This preliminary study was conducted to...
Amlodipine Targeting SPINK1 Attenuates Lung Cancer Cell Growth and Proliferation Through Glycolytic Metabolism [0.03%]
氨氯地平靶向SPINK1通过糖酵解代谢抑制肺癌细胞增殖生长
Guojun Yue,Lingyun Yue,Yan Chen et al.
Guojun Yue et al.
Introduction: A trypsin inhibitor, the serine peptidase inhibitor, Kazal type 1 (SPINK1), a secreted protein, has been identified in recent years as contributing to the advancement of specific cancer types. Lung cancer is...
Chitosan-Gold Nanogel Loaded with Doxorubicin: An Enhanced Delivery System for NSCLC Lung Cancer [0.03%]
壳聚糖-黄金纳米凝胶加载多柔比星：一种增强NSCLC肺癌传递系统
Elham Aminirad,Tala Haghnazari Esfahlan,Ali Rajabi et al.
Elham Aminirad et al.
Introduction: Lung Cancer (LC) is the leading cause of cancer deaths globally. Long non-coding RNAs (lncRNAs) have emerged as important regulators in lung cancer, playing key roles in tumor development and metastasis. Rec...
Ginkgolide A Suppresses Osteosarcoma Proliferation and Activates the Apoptotic Pathway by Targeting the KAT2A-H3K18la Lactylation Axis [0.03%]
银杏内酯A通过靶向KAT2A-H3K18la乳酰化轴抑制骨肉瘤增殖并激活凋亡途径
Chunfeng Fu,Jiaqin Wu,Shuwan Hou et al.
Chunfeng Fu et al.
Introduction: Osteosarcoma (OS) is a highly aggressive primary bone malignancy characterized by profound metabolic reprogramming and limited therapeutic options. Although histone lactylation has recently emerged as a meta...
MVs and MVs-Crocin as Novel Therapeutic Agents for Lung Cancer, Apoptosis, and Gene Regulation [0.03%]
用于肺癌、凋亡和基因调节的新型药物MVs和MVs-Crocin
Hosein Keshavaerz,Bita Zand,Leila Sadat Nilchiani et al.
Hosein Keshavaerz et al.
Introduction: Lung cancer is one of the most common malignancies worldwide. Stem cells and their secretions have recently attracted attention as potential therapeutic agents due to their anti-cancer properties. This study...
Current Progress and Future Opportunities in Liquid Biopsy for Cancer Detection [0.03%]
循环肿瘤DNA液体活检技术的现状与未来展望：癌症早期检测与预后监控中的应用前景与发展挑战
Mehrdad Yasaei,Ahmad Fazilat,Ali Khavanin et al.
Mehrdad Yasaei et al.
Introduction: Cancer is a leading cause of death worldwide, with many cancers lacking effective early screening methods. Early diagnosis is critical for improving survival and quality of life, and for reducing the financi...
Anticancer and Drug-Likeness Evaluation of Allylphenol-Based 15-LOX Inhibitors in Prostate Cancer: An In Vitro and Computational Study [0.03%]
基于 allylphenol 的 15-LOX 抑制剂的抗前列腺癌及类药性评价：体外和计算研究
Elahe Khezri,Hamid Sadeghian,Melika Ehtesham Gharaee et al.
Elahe Khezri et al.
Background: Prostate cancer remains the second most common cancer among men around the world, with 1.4 million new cases annually. Treatment resistance and off-target toxicity require innovative therapeutic approaches. Na...