Preparation and Characterization of Raloxifene- and Rutin-Co-loaded Chitosan Nanoparticles for the Treatment of Colon Cancer [0.03%]
用于结肠癌治疗的他莫西芬和芸香素共载壳聚糖纳米颗粒的制备及表征
Farah Al-Sahlawi,Ali Al-Samydai,Aya Yaseen Mahmood Alabdali et al.
Farah Al-Sahlawi et al.
Introduction: Colorectal cancer is a significant health concern with high incidence and mortality rates. Raloxifene (RLX) is a selective estrogen receptor modulator that blocks estrogen receptors, reducing the risk of est...
MicroRNA-21 in Cancer and Fibrosis: Molecular Mechanisms and Therapeutic Progress [0.03%]
癌症与纤维化中的微小核糖核酸-21：分子机制和治疗进展
Anushka Sharma,Awaneet Kaur,Javed Khan et al.
Anushka Sharma et al.
MicroRNA-21 (miR-21) is a key regulator of gene expression involved in cancer progression and fibrosis. Its dysregulation promotes cell proliferation, resistance to apoptosis, Epithelial-Mesenchymal Transition (EMT), and Extracellular Matri...
Kamlesh Sharma
Kamlesh Sharma
Spirooxindoline derivatives have emerged as promising scaffolds in cancer therapy due to their structural diversity and potent cytotoxic effects. This review summarizes progress in the structural design and biological assessment of spirooxi...
CAF Heterogeneity in Ovarian Cancer: Implications for Chemoresistance and Treatment Strategies [0.03%]
卵巢癌中CAF异质性对化疗耐药及治疗策略的影响
Sambasivam Gopinath,Pavithra Balakrishnan,Yamini Muli et al.
Sambasivam Gopinath et al.
Introduction: Cancer-Associated Fibroblasts (CAFs) are key players in the tumor microenvironment (TME) of ovarian cancer, influencing progression and chemoresistance. Their heterogeneous subtypes contribute distinctly to ...
Nucleobase Ionic Liquids (NBILs) Induced Apoptosis via Caspase 3 Activation and in silico Regulation of the IRE1a Pathway in Pancreatic Cancer PANC-1 Cells [0.03%]
核碱基离子液体通过激活 caspase 3 和调节胰腺癌 PANC-1 细胞中的 IRE1a 通路诱导细胞凋亡
Pradnya Patil,Prakash Bansode,Gaurang Telang et al.
Pradnya Patil et al.
Introduction: Globally rising incidences of pancreatic cancer, a leading cause of death, have made it imperative to explore new chemotherapeutic agents, such as ionic liquids (ILs), as an emerging class of anticancer agen...
Caffeic Acid Phenethyl Ester (CAPE) Inhibits Hepatocellular Carcinoma Growth and Angiogenesis via Vascular Endothelial Growth Factor Suppression: A Preclinical Evidence [0.03%]
咖啡酸苯乙酯通过抑制血管内皮生长因子抑制肝癌增殖和新生血管形成：一项临床前证据
Lei Gong,Wenzhen Wang,Zenghua Deng et al.
Lei Gong et al.
Introduction: Caffeic acid phenethyl ester (CAPE), a natural compound, has shown antitumor potential, but its efficacy and mechanism in hepatocellular carcinoma (HCC) require further validation, particularly in vivo. This...
Preclinical Evaluation of the Methyl (Z)-2-(isothioureidomethyl)-2-pentenoate Hydrobromide: Antitumor Efficacy and Safety Profile in a Murine Melanoma Model [0.03%]
甲基(Z)-2-((异硫脲甲基)亚戊烯酸溴化氢的药效和安全性评价
Laura Sartori Assunção,Iara Fabrícia Kretzer,Ana Gabriela Rosa et al.
Laura Sartori Assunção et al.
Introduction: Melanoma is a malignancy often resistant to conventional therapies, highlighting the need for novel agents that effectively target tumor progression and subdue apoptotic resistance. Isothiouronium salts have...
Anticancer Potential of Eudesmanolides Derived from Sphagneticola trilobata against Colorectal Cancer, by Targeting β-catenin Signalling [0.03%]
三叶梅隐品烷醇类衍生物抗结肠癌作用的研究及其β-catenin信号转导通路靶点研究
Remya Johny,Faisal Moossa Athikkavil,Sreekumar U Aiswarya et al.
Remya Johny et al.
Introduction: The role of β-catenin signalling in the pathogenesis of Colorectal Cancer (CRC) is indisputable. In this study, we report the identification of a cytotoxic fraction that targets the β-catenin signalling ax...
The Emerging Role of Histone Methyltransferase ASH1L in Tumor Development [0.03%]
组蛋白甲基转移酶ASH1L在肿瘤发生中的作用机制研究初探
Xiang-Yu Zhang,Yue Li
Xiang-Yu Zhang
Histone modifications play a fundamental role in epigenetic regulation. Histone methylation mediated by enzymes like absent, small, or homeotic discs 1-like (ASH1L) has emerged as a critical process in normal cellular function and disease, ...
Chitosan-Graphene Composite for Drug Delivery in Cancer Therapy: Recent Progress and Advances [0.03%]
壳聚糖石墨烯复合物在癌症治疗中的药物递送：近期进展与展望
Negar Lari Lavasani,Mohammad Hossein Roozbahani,Seyed Morteza Naghib
Negar Lari Lavasani
This review focuses on anticancer drug delivery systems using graphene/chitosan (CS) nanocomposites, and the present discussion explores the potential of chitosan/graphene oxide composites and their applications in wound dressings and drug ...