Targeting Ceramide Metabolism to Overcome Osimertinib Resistance in EGFR-mutant Non-Small Cell Lung Cancer: An In Vitro, Network Pharmacology, and In Silico Study [0.03%]
针对表皮生长因子受体突变非小细胞肺癌奥希替尼耐药的丝氨酸 palmitoyltransferase 抑制剂——体内、网络药理学和计算机模拟研究
Oğuzhan Selvi,Canan Vejselova Sezer,Mustafa Cengiz et al.
Oğuzhan Selvi et al.
Introduction: Osimertinib, an irreversible epidermal growth factor receptor inhibitor, is recognized for use in non-small cell lung cancer patients with the T790M resistance mutation. Though osimertinib offers a valuable ...
Near-Infrared Theranostics: Cutting-Edge Innovations in Cancer Diagnosis and Therapy [0.03%]
癌症诊断和治疗的近红外诊疗最新技术进展
Kritika,Amar Deep Ankalgi,Nikhil Sharma et al.
Kritika et al.
Introduction: Theranostics of near-infrared (NIR) imaging, which originated from the merging of diagnostic imaging and targeted therapy, is one of the most remarkable achievements in the early diagnosis and treatment of m...
Extracellular Vesicles and Their Multifaceted Roles in Cancer: Current Evidence from a Narrative Review [0.03%]
细胞外囊泡在癌症中的多种作用：叙事性综述的当前证据
Himanshu Singh,Ranjeet Kumar Yadav,Anmol Dogra
Himanshu Singh
Introduction: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanoscale, lipid bilayer-enclosed particles released by diverse cell types. They play a key role in intercellular communication by tran...
Evaluation of the Effects of Bryonia multiflora Extract in a Chemically Induced Rat Breast Cancer Model [0.03%]
评估白首乌提取物对化学诱导的大鼠乳腺癌模型的作用效果
Özgür Aslan,Ayhan Yıldırım,Mehmet Hanifi Durak
Özgür Aslan
Introduction: To evaluate the effects of dietary Bryonia multiflora Boiss. & Heldr. (B. multiflora) Extract, a rat breast cancer model was used that had been induced chemically with 7,12-dimethylbenz[a]anthracene (DMBA). ...
Rama Sharma
Rama Sharma
Objectives: The study aims to examine the structural features, functional capabilities, and therapeutic applications of ferritin nanocages in treating cancer, emphasizing their potential as multifunctional platforms for t...
7MeERT Enhances Antibody-Drug Conjugate Efficacy in Glioblastoma by Inducing AMPK-p38MAPK-Mediated Non-Canonical Endocytosis of EGFRvIII [0.03%]
7 MeERT通过诱导AMPK-p38MAPK介导的非经典内吞作用增强EGFRvIII抗体药物偶联物在胶质母细胞瘤中的疗效
Sonoko Atsumi,Chisato Nosaka,Takefumi Onodera et al.
Sonoko Atsumi et al.
Introduction: Antibody-drug conjugates (ADCs) targeting EGFR variant III (EGFRvIII) hold promise for glioblastoma therapy, but clinical efficacy is limited by poor receptor internalization. ...
Exploring the Therapeutic Potential of an Iron(III)-Polysaccharide Complex Derived from Hypsizygus ulmarius [0.03%]
来源于Hypsizygus ulmarius的铁(III)多糖配合物的治疗潜力研究
Sudha Govindan,Abinaya Nagarajan,Amritha Sukumaran et al.
Sudha Govindan et al.
Introduction: This current research involves the synthesis and biological evaluation of an iron complex derived from the Hypsizygus ulmarius polysaccharide (HUP-Fe(III)), with the aim of determining its potential as an ir...
A Meta-Analysis and Systematic Review of the Frequency, Clinicopathological Features, and Diagnostic Potential of CDH1 Methylation in Head and Neck Cancer [0.03%]
CDH1甲基化在头颈鳞癌中的临床和病理特征及诊断价值的系统评价和meta分析研究
Mubarak Alqahtani,Abdulmohsin Mohammed Alzuhairi,Osama Hasan Alalmaie et al.
Mubarak Alqahtani et al.
Introduction: Head and neck cancer (HNC), particularly head and neck squamous cell carcinoma (HNSCC), is a major global health issue. Epigenetic alterations, especially the hypermethylation of tumor suppressor genes (TSGs...
Recent Advances in Intravesical Chemotherapy: Insights into the FDA-Approved Gemcitabine-Releasing TAR-200 System for Bladder Cancer Management [0.03%]
近年膀胱内化疗进展：FDA批准的用于膀胱癌治疗的吉西他滨缓释TAR-200系统的新见解
Abhishek Sharma,Aman Kumar,Preeti Patel et al.
Abhishek Sharma et al.
The FDA approval of the gemcitabine intravesical system (Inlexzo/TAR-200) marks a breakthrough for BCG-unresponsive NMIBC with CIS. This novel drug-device combination enables sustained intravesical chemotherapy, achieving high complete resp...
QSAR Modeling of Camptothecin Derivatives Targeting Topoisomerase I: Structural Insights for Anticancer Drug Design [0.03%]
拓扑异构酶I的 camptothecin 衍生物的 QSAR 模型及抗癌药物设计的结构启示
Hossam A Mahmoud,Noha A Elnady,Salma A Elmallah
Hossam A Mahmoud
Introduction: This study investigates the quantitative structure-activity relationship (QSAR) of camptothecin derivatives to determine how variations in their structures affect the activity of these derivatives on Topoiso...