Euxanthone Inhibits Hepatocellular Carcinoma Progression by Targeting the miR-199a-5p/E2F3 Regulatory Axis [0.03%]
硫黄酮通过靶向miR-199a-5p/E2F3轴抑制肝癌进展
Ahmed Abdullah Al Awadh
Ahmed Abdullah Al Awadh
Background: Hepatocellular carcinoma (HCC) ranks among the leading causes of cancer-related deaths on a global scale. This study aimed to evaluate the effects of euxanthone on the proliferation of HCC cell lines and eluci...
Evaluation of Anticancer Potential in Human Colorectal Carcinoma HCT-116 Cells by Fungal-Mediated Zinc Oxide Nanoparticles [0.03%]
丝状真菌介导的氧化锌纳米粒子对人类结直肠癌HCT-116细胞抗肿瘤潜力的评价
Yaser E Alqurashi,Sami G Almalki,Ibrahim M Ibrahim et al.
Yaser E Alqurashi et al.
Introduction: Chemotherapy faces limitations such as toxicity and resistance, necessitating novel cancer treatments. Green-synthesized zinc oxide nanoparticles (ZnO-NPs) have attracted attention for their safety, biocompa...
Microbial-Derived Anti-Cancer Compounds: Advances in Drug Discovery, Bioengineering, and Therapeutic Applications [0.03%]
微生物抗肿瘤化合物：药物发现、生物工程和治疗应用的新进展
Ekta Tyagi,Divya Jain,Rajabrata Bhuyan et al.
Ekta Tyagi et al.
Introduction: Microbial metabolites represent a valuable source of bioactive compounds with promising anticancer properties. However, conventional drug discovery approaches are time-intensive and resource-demanding. ...
Himanshu Singh,Rajnish Kumar,Avijit Mazumder
Himanshu Singh
Background: Lung cancer remains a leading cause of cancer-related deaths worldwide, with its incidence continuing to rise. Despite advancements in clinical treatments, their effectiveness is often restricted, emphasizing ...
Long Non-Coding RNA VPS9D1-AS1 in Human Cancer: Functions, Mechanisms, and Clinical Utility [0.03%]
长非编码RNA VPS9D1-AS1在人类癌症中的功能、机制和临床应用
Jingjie Yang,Haodong He,Haoran Liu et al.
Jingjie Yang et al.
Introduction: VPS9 domain-containing 1 antisense RNA 1 (VPS9D1-AS1), also known as c-Mycupregulated lncRNA (MYU) and FAK-interacting and stabilizing lncRNA (FAISL), is a novel long non-coding RNA (lncRNA) located at the h...
Narrative Review Article A Comprehensive Review of the Anticancer Activity of Farnesiferol C and Umbelliferone [0.03%]
法内西菲醇C和伞形花内酯抗肿瘤活性的全面综述性评论文章
Reyhane Faghih,Mehrshad Talebi-Esmaeilan,Seyed Mahdi Mohamadi-Zarch et al.
Reyhane Faghih et al.
Cancer remains a growing challenge in modern society, presenting a significant obstacle in both developed and developing countries. Conventional treatments are often costly and limited by issues such as drug resistance and undesirable side ...
Ursolic Acid Inhibits Triple-Negative Breast Cancer Progression by Modulating the FGFR1/AKT/ERK Pathway: Evidence from Network Pharmacology and Experimental Validation [0.03%]
乌索林酸通过调节FGFR1/AKT/ERK途径抑制三阴性乳腺癌的发展：基于网络药理学和实验验证的证据
Ziming Chen,Weiqiang Guo,Yahan Gao et al.
Ziming Chen et al.
Introduction: Ursolic acid (UA) exhibits antitumor activity; however, its effects and mechanisms on triple-negative breast cancer (TNBC) cells are not well understood. The present study aimed to explore the anti- TNBC mec...
Genetic and Molecular Determinants of Immunotherapy Response in Recurrent Ovarian Cancer [0.03%]
复发性卵巢癌免疫治疗反应的基因组和分子决定因素
Hamid Noori,Sana Aqil Khan,Mohamed Hisham Alamin et al.
Hamid Noori et al.
Ovarian cancer remains a significant public health challenge. It originates in the ovaries and presents in various histological subtypes. Surgery and chemotherapy are the most suitable treatments to combat this disease. This study aims to p...
Design, Synthesis, Antimicrobial and Antitumor Activities of Benzo[f]chromene Derivatives: DFT and Molecular Docking [0.03%]
苯并.chrome衍生物的设计、合成及其抗菌和抗肿瘤活性研究：DFT及分子对接探讨
Rita M A Borik,Ashraf H F Abdelwahab,Abdullah A Alamri et al.
Rita M A Borik et al.
Introduction: Benzochromenes are heterocyclic compounds of growing interest in medicinal chemistry due to their diverse biological activities, including antioxidant, anticancer, and antimicrobial properties. ...
Gaussian-based 3D-QSAR and Pharmacophore Mapping Studies of Indole Derivatives as Aromatase Inhibitors [0.03%]
基于高斯的三维定量结构活性关系及芳香酶抑制剂吲哚衍生物的药效团映射研究
Neha Bhatia,Suresh Thareja
Neha Bhatia
Introduction: Aromatase inhibition is one of the most effective strategies for the treatment of ER+ breast cancer, which accounts for about 70% of breast cancer cases. Indole-based aromatase inhibitors have altered the dy...