Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents [0.03%]
血管壁的病理生理及其与老年啮齿动物脑血管疾病的相关性
A Popa-Wagner,D Pirici,E B Petcu et al.
A Popa-Wagner et al.
Chronic hypertension and cerebral amyloid angiopathy (CAA) are the main pathologies which can induce the rupture of cerebral vessels and intracerebral hemorrhages, as a result of degenerative changes in the vascular wall. A lot of progress ...
Spinal microvascular expression of PV-1 is associated with inflammation, perivascular astrocyte loss, and diminished EC glucose transport potential in acute SCI [0.03%]
急性脊髓损伤后PV-1在脊髓微血管中的表达与炎症、血管周围星形胶质细胞丢失和内皮细胞葡萄糖转运能力下降有关
Anthony B Mozer,Scott R Whittemore,Richard L Benton
Anthony B Mozer
The endothelial-specific expression of plasmalemmal vesicle associated protein-1 (PV-1) is typical of fenestrated endothelium observed in pulmonary capillaries and some endocrine organs. In the central nervous system (CNS) it is expressed d...
Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia [0.03%]
静脉植入的神经干细胞迁移到损伤部位后可减少脑缺血引起的梗死体积并改善行为症状
Chiung-Chyi Shen,Chen-Huan Lin,Yi-Chin Yang et al.
Chiung-Chyi Shen et al.
Stroke represents one of the leading causes of death and disability in humans, but despite intense research, only a few options exist for the treatment of stroke-related infarction of brain tissue. Thus far, in experimental strokes, cell th...
Pitavastatin and 4'-hydroxy-3'-methoxyacetophenone (HMAP) reduce cognitive dysfunction in vascular dementia during experimental diabetes [0.03%]
pitavastatin和4'-羟基-3'-甲氧基乙酰苯酮(HMAP)可改善糖尿病血管性痴呆模型大鼠认知功能障碍
Bhupesh Sharma,Nirmal Singh
Bhupesh Sharma
Diabetes has been found to increase the probability of vascular dementia in humans. We have investigated the effect of 4'-hydroxy-3'-methoxyacetophenone (HMAP), a NADPH oxidase inhibitor and Pitavastatin, HMG Co-A reductase inhibitor, on St...
Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1 [0.03%]
高半胱氨酸通过ICAM-1促进单核细胞穿过脑微血管内皮细胞层向迁移
Lindsay A Hohsfield,Christian Humpel
Lindsay A Hohsfield
Increased homocysteine (Hcy) levels contribute to a variety of cardiovascular and cerebrovascular diseases including stroke and Alzheimer's disease. Recent data has shown that elevated levels of Hcy can lead to the blood-brain barrier (BBB)...
Angelica injection promotes peripheral nerve structure and function recovery with increased expressions of nerve growth factor and brain derived neurotrophic factor in diabetic rats [0.03%]
当归注射液促进糖尿病大鼠外周神经结构和功能恢复并增加神经生长因子及脑源性神经营养因子的表达
Ruilin Li,Junjian Zhang,Lei Zhang et al.
Ruilin Li et al.
Several nervous system injury models, such as sciatic crush and chronic cerebral hypoperfusion have been well studied in terms of neuroprotective effect of angelica injection. However, definitive experimental studies are lacking on diabetic...
Endogenous agmatine inhibits cerebral vascular matrix metalloproteinases expression by regulating activating transcription factor 3 and endothelial nitric oxide synthesis [0.03%]
内生精氨通过调节活化转录因子3和内皮一氧化氮合酶抑制脑血管基质金属蛋白酶表达
Hyun Joo Jung,Mei Zi Yang,Ki Hyo Kwon et al.
Hyun Joo Jung et al.
Earlier investigations from our laboratory demonstrated that the expression of matrix metalloproteinases (MMPs) was down-regulated by exogenously administered agmatine against ischemia-like injuries in the murine brain capillary endothelial...
Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation [0.03%]
瘦素和白细胞介素-1β调节神经元谷氨酸释放并保护缺糖缺氧损伤
Chen-Hsuan Wang,Wei-Ti Wang,Shu-Yun Cheng et al.
Chen-Hsuan Wang et al.
Molecular mechanism underlying leptin-mediated neuronal protection against glucose-oxygen-serum deprivation (GOSD) insult was investigated by focusing on the interactions among leptin, Interleukin-1beta (IL-1beta) and glutamate and their im...
Liuwang Zeng,Zhiping Hu,Wei Lu et al.
Liuwang Zeng et al.
Small heat shock proteins(sHSPs), with a small molecular mass of 12-43 kDa, are molecular chaperones that protect cells against stress by assisting them in the correct folding of denatured proteins and thus prevent aggregation of misfolded ...
CD133 expressing pericytes and relationship to SDF-1 and CXCR4 in spinal cord injury [0.03%]
脊髓损伤后表达CD133的周细胞及其与SDF-1和CXCR4的关系
Ursula Graumann,Marie-Françoise Ritz,Bertha Gutierrez Rivero et al.
Ursula Graumann et al.
Compression injury to the spinal cord (SC) results in vascular changes affecting the severity of the primary damage of the spinal cord. The recruitment of bone marrow (BM)-derived cells contribute to revascularization and tissue regeneratio...