Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress [0.03%]
促红细胞生成素通过SIRT1长寿途径在氧化应激期间促进内皮血管完整性
Jinling Hou,Shaohui Wang,Yan Chen Shang et al.
Jinling Hou et al.
Given the cytoprotective ability of erythropoietin (EPO) in cerebral microvascular endothelial cells (ECs) and the invaluable role of ECs in the central nervous system, it is imperative to elucidate the cellular pathways for EPO to protect ...
CD133+ glioblastoma stem-like cells induce vascular mimicry in vivo [0.03%]
CD133阳性胶质母细胞瘤干细胞在体内外诱导血管模似现象
Ming-Tsang Chiao,Yi-Chin Yang,Wen-Yu Cheng et al.
Ming-Tsang Chiao et al.
Glioblastoma is one of the most angiogenic malignancy, the neoplastic vessels of which are likely to arise by angiogenesis and vasculogenesis. An alternative mechanism of tumor vasculature is described, termed vasculogenic mimicry, by which...
Neuroprotective efficacy of the peroxisome proliferator-activated receptor-γ ligand in chronic cerebral hypoperfusion [0.03%]
增生激活受体-γ配体对慢性脑低灌注的神经保护作用
Hale Sayan-Ozacmak,V Haktan Ozacmak,Figen Barut et al.
Hale Sayan-Ozacmak et al.
Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-γ agonists were shown to modulate inflammatory response and neuronal death following cer...
Safety of vascular endothelial and hepatocyte growth factor gene therapy in patients with critical limb ischemia [0.03%]
血管内皮细胞生长因子和肝细胞生长因子基因治疗治疗严重肢体缺血患者的临床安全性研究
Andrei Anghel,Georgel Taranu,Edward Seclaman et al.
Andrei Anghel et al.
The present clinical trial analyzed the safety of gene therapy using plasmidial constructs expressing vascular endothelial and hepatocyte growth factors in patients with critical limb ischemia. The study included 43 patients: 29 in the trea...
WITHDRAWN: [0.03%]
撤回
J Zhao,S Yu,J Wu et al.
J Zhao et al.
Ahead of Print article withdrawn by publisher.
Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation [0.03%]
花生四烯酸二醇酯激活人类血小板：PKC在NO/cGMP途径调制中的作用
Maria Grazia Signorello,Enrica Giacobbe,Alessia Segantin et al.
Maria Grazia Signorello et al.
We demonstrated that the endocannabinoid 2-arachidonoylglycerol (2-AG) activated dose-dependently washed human platelets and increased intracellular calcium levels. Moreover 2-AG activated protein kinase C measured as p47pleckstrin phosphor...
Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity [0.03%]
胆红素升高和长期暴露损害人脑微血管内皮细胞的完整性
Inês Palmela,Filipa L Cardoso,Michael Bernas et al.
Inês Palmela et al.
The pathogenesis of encephalopathy by unconjugated bilirubin (UCB) seems to involve the passage of high levels of the pigment across the blood-brain barrier (BBB) and the consequent damage of neuronal cells. However, it remains to be clarif...
Experimental model considerations for the study of protein-energy malnutrition co-existing with ischemic brain injury [0.03%]
探讨蛋白质-能量营养不良合并脑缺血损伤动物模型的选择及建模方法学问题
Erin J Prosser-Loose,Shari E Smith,Phyllis G Paterson
Erin J Prosser-Loose
Protein-energy malnutrition (PEM) affects ~16% of patients at admission for stroke. We previously modeled this in a gerbil global cerebral ischemia model and found that PEM impairs functional outcome and influences mechanisms of ischemic br...
Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin [0.03%]
磷二酯酶-III抑制剂通过上调血管内皮细胞粘附分子-1对脑微血管内皮细胞OGD损伤的保护作用
Mitsunori Ishiguro,Yukiya Suzuki,Keisuke Mishiro et al.
Mitsunori Ishiguro et al.
We recently reported that a phosphodiesterase-III inhibitor, cilostazol, prevented the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tissue plasminogen activator (tPA) and that it reversed tPA-induced ce...
Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact [0.03%]
一种针对脑部的-docosahexaenoic酸形式用于实验性中风治疗：MRI评估与抗氧化作用
Fabien Chauveau,Tae-Hee Cho,Magali Perez et al.
Fabien Chauveau et al.
Epidemiologic studies report cardiovascular protection conferred by omega-3 fatty acids, in particular docosahexaenoic acid (DHA). However, few experimental studies have addressed its potential in acute stroke treatment. The present study u...