Short-term high-dose effect of lovastatin on thrombolysis by rt-PA in a human whole-blood in vitro clot model [0.03%]
洛伐他汀短期大剂量对人全血体外血栓模型rt-PA溶解血栓的影响
Madhuvanthi A Kandadai,Jason Meunier,Christopher J Lindsell et al.
Madhuvanthi A Kandadai et al.
High-dose hydroxymethylglutaryl coenzyme. A reductase inhibitor (statin) administration reduces neuronal injury and improves outcomes in experimental models of acute ischemic stroke, and has been shown to be safe in a phase 1 dose-escalatio...
Kenneth Maiese
Kenneth Maiese
Cisternal sustained release dihydropyridines for subarachnoid hemorrhage [0.03%]
脑池内缓释型二氢吡啶类药物治疗蛛网膜下腔出血
Douglas J Cook,Sabrina Kan,Jinglu Ai et al.
Douglas J Cook et al.
Nimodipine improved outcome in patients with subarachnoid hemorrhage (SAH) although hypotension limited the dose that could be administered systemically. Subarachnoid delivery of nicardipine or nimodipine may be more efficacious. We tested ...
Comparative Study
Current neurovascular research. 2012 May;9(2):139-48. DOI:10.2174/156720212800410894 2012
Dual targeting of glioma U251 cells with nanoparticles prevents tumor angiogenesis and inhibits tumor growth [0.03%]
纳米颗粒联合靶向治疗胶质瘤U251细胞可防止肿瘤血管生成并抑制肿瘤生长
Hongjie Chen,Kaichun Fan,Shousen Wang et al.
Hongjie Chen et al.
Important advances have been made within in past few years in the treatment of glioma, however, the longterm prognosis after resection of glioma remains unsatisfactory as a result of a high incidence of recurrence. To solve this problem, ma...
Serum bilirubin after acute ischemic stroke is associated with stroke severity [0.03%]
急性缺血性脑卒中后的血清胆红素水平与卒中严重程度相关
Yun Luo,Jing-Wei Li,Zheng-Juan Lu et al.
Yun Luo et al.
Elevated serum bilirubin was prevalent in the acute ischemic stroke (AIS), which was induced in response to oxidative stress and could display the intensity of oxidative stress. As more severe stroke is linked with higher level of oxidative...
Multigate quality Doppler profiles and morphological/hemodynamic alterations in multiple sclerosis patients [0.03%]
多发性硬化患者的多门控质量多普勒图谱和形态/血流动力学改变
Marco Matteo Ciccone,Aldo Innocente Galeandro,Pietro Scicchitano et al.
Marco Matteo Ciccone et al.
Venous echo-color-Doppler (ECD) showed that chronic cerebrospinal venous insufficiency (CCSVI) syndrome is related to multiple sclerosis (MS). Study aims were to assess interobserver variability in ultrasound evaluation of MS patients and t...
Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates [0.03%]
脑内神经元和胶质相关血管层粘连蛋白的表达变化及时间进程：海人酸诱导模型中的研究
Sumit Sarkar,James Raymick,Larry Schmued
Sumit Sarkar
We recently demonstrated a dramatic up regulation of laminin expression within the blood vessels of brain regions vulnerable to excitotoxin mediated neuronal degeneration. Although this effect was clearly demonstrable at 2 days post kainic ...
Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation [0.03%]
通过抑制p38磷酸化过程中的VEGF诱导的血管生成作用来抑制角黄素类胡萝卜素衍生物的作用
Naofumi Umigai,Junji Tanaka,Kazuhiro Tsuruma et al.
Naofumi Umigai et al.
We evaluated the protective effects of crocetin against angiogenesis induced by vascular endothelial growth factor (VEGF). Crocetin, the aglycone of crocin carotenoids, is found in saffron crocus (Crocus sativus L.) and gardenia fruit (Gard...
WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy [0.03%]
WISP1（CCN4）在氧化应激过程中自身调节其表达及β-连环蛋白的核转运，并对神经元自噬作用有限
Shaohui Wang,Zhao Zhong Chong,Yan Chen Shang et al.
Shaohui Wang et al.
Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4) is a CCN family member more broadly identified with development and tumorigenesis. However, recent studies have shed new light and enthusiasm on WISP1 as a novel target directed agains...
Irene Ciancarelli,Caterina Di Massimo,Daniela De Amicis et al.
Irene Ciancarelli et al.
Measurements of the redox balance after the ischemic stroke occurrence might be useful to monitor the outcome of patients who suffered an ischemic stroke in terms of stroke recurrence and other vascular events. For this purpose, fifteen pat...