Single nucleotide polymorphism and serum levels of VEGFR2 are associated with age related macular degeneration [0.03%]
血管内皮生长因子受体2单核苷酸多态性与年龄相关性黄斑变性的关联研究
Neel Kamal Sharma,Amod Gupta,Sudesh Prabhakar et al.
Neel Kamal Sharma et al.
Age-related macular degeneration (AMD) is a leading cause of blindness and is the third leading cause of blindness. Genetic factors are known to influence an individual's risk for developing AMD. Linkage has earlier been shown to the vascul...
Anti-endothelial cell antibodies in patients with cerebral small vessel disease [0.03%]
脑小血管病患者的内皮细胞抗体检测
Akio Kimura,Takeo Sakurai,Megumi Yamada et al.
Akio Kimura et al.
The pathogenesis of cerebral small vessel disease (CSVD) in the elderly is poorly understood. Endothelial cell activation and dysfunction may play a causal role in the pathogenesis of CSVD. It was reported that anti-endothelial cell antibod...
Randomized Controlled Trial
Current neurovascular research. 2012 Nov;9(4):296-301. DOI:10.2174/156720212803530726 2012
Short-term intra-nasal erythropoietin administration with low sialic acid content is without toxicity or erythropoietic effects [0.03%]
低含量唾液酸的短期鼻内给药无毒且不具备促红细胞生成作用
Alicia Lagarto,Viviana Bueno,Jose A Sanchez et al.
Alicia Lagarto et al.
The objective of this investigation was to assess the toxicological potential of nasal formulation of erythropoietin with low sialic acid content (Neuro EPO) after 28 days of intra-nasal dosing in rats besides to evaluate the immunogenicity...
Human umbilical cord mesenchymal stem cell therapy on neuromyelitis optica [0.03%]
人脐带间充质干细胞治疗视神经脊髓炎谱系病
Zhengjuan Lu,Dan Ye,Lai Qian et al.
Zhengjuan Lu et al.
Stem cell transplantation is a promising therapy for neuromyelitis optica (NMO). Among stem cell varieties, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess many advantages, add a differential potential into neural cel...
Deletion of endoplasmic reticulum stress-induced CHOP protects microvasculature post-spinal cord injury [0.03%]
内质网应激诱导的CHOP凋亡在脊髓损伤后的血管病变中的作用及机制研究
Janelle M Fassbender,Sujata Saraswat-Ohri,Scott A Myers et al.
Janelle M Fassbender et al.
Trauma introduces damaging stressors that compromise protein, lipid, and nucleic acid integrity. Aggregates of unfolded and misfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response (ERSR)/unfolded protein respons...
Delayed cerebral ischemia after subarachnoid hemorrhage: from vascular spasm to cortical spreading depolarizations [0.03%]
蛛网膜下腔出血后的迟发性脑缺血：从血管痉挛到皮层扩散去极化
Zelong Zheng,Renan Sanchez-Porras,Edgar Santos et al.
Zelong Zheng et al.
Non-traumatic subarachnoid hemorrhage (SAH) represents about 5 to 6% of the overall incidence of stroke and is associated with high morbidity and mortality. Despite the substantial research and clinical efforts, delayed cerebral ischemia (D...
Doxorubicin-induced in vivo nephrotoxicity involves oxidative stress-mediated multiple pro- and anti-apoptotic signaling pathways [0.03%]
多柔比星肾毒性涉及氧化应激介导的多种促凋亡和抗凋亡信号途径
Tejas S Lahoti,Darshan Patel,Venkatesh Thekkemadom et al.
Tejas S Lahoti et al.
Doxorubicin (DOX), a prominent anticancer agent has enjoyed considerable popularity in the last few decades because of its usefulness in the management of various forms of cancers, but its organotoxic potential (cardio-, hepatoand nephrotox...
Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia [0.03%]
Wnt1诱导信号途径蛋白1（WISP1）通过靶向PRAS40调控β淀粉样肽诱发的小胶质细胞凋亡损伤
Yan Chen Shang,Zhao Zhong Chong,Shaohui Wang et al.
Yan Chen Shang et al.
Given the present challenges to attain effective treatment for β-amyloid (Aβ) toxicity in neurodegenerative disorders such as Alzheimer's disease, development of novel cytoprotective pathways that can assist immune mediated therapies thro...
Oxidative stress in post-acute ischemic stroke patients after intensive neurorehabilitation [0.03%]
强化神经康复后急性脑卒中患者氧化应激的状态
Irene Ciancarelli,Daniela De Amicis,Caterina Di Massimo et al.
Irene Ciancarelli et al.
We investigated in post-acute ischemic stroke patients the influence of intensive neurorehabilitation on oxidative stress balance during recovery of neurological deficits. For this purpose, fourteen patients were included in the study withi...
Biomarkers in amyotrophic lateral sclerosis: is there a neurovascular pathway? [0.03%]
肌萎缩侧索硬化症中的生物标志物：是否存在神经血管途径？
Himshikha Bhutani,Akshay Anand
Himshikha Bhutani
The establishment of a link between VEGF, hypoxia and ALS pathogenesis placed angiogenic factors and oxidative stress at the focal point for further studies. Recreation of a phenotype strikingly similar to that of mutant SOD1 mouse and huma...