Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress [0.03%]
丁酸钠具有抗抑郁作用并改善模型的认知功能，并通过提高神经营养素的表达来增强神经保护作用
Samira Silva Valvassori,Roger Bitencourt Varela,Camila Orlandi Arent et al.
Samira Silva Valvassori et al.
It is known that cognitive processes, such as learning and memory, are affected in depression. Several authors have described histone deacetylase (HDAC) inhibitors as a class of drugs that improves long-term memory formation. The current st...
The phosphodiesterase III inhibitor cilostazol ameliorates ethanolinduced endothelial dysfunction [0.03%]
磷二酯酶III抑制剂西洛他唑改善酒精诱导的血管内皮功能障碍
Toshinori Takagi,Keisuke Mishiro,Masamitsu Shimazawa et al.
Toshinori Takagi et al.
Intracranial hemorrhage (ICH) remains a devastating disease, and heavy alcohol consumption is an underlying risk factor. The aim of this study was to study the mechanism of ethanol-induced endothelial cell damage and to evaluate the protect...
A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms [0.03%]
内源性基因的变异与散发性颅内动脉瘤发病相关
Yahui Lin,Hui Yu,Weihua Song et al.
Yahui Lin et al.
Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene hav...
Seyed Fazel Nabavi,Huige Li,Maria Daglia et al.
Seyed Fazel Nabavi et al.
Stroke is one of the most common cardiovascular diseases and is known as a leading cause of death in the world. Despite to its high prevalence, there are limited effective therapeutic strategies for stroke till now. However, oxidative stres...
WISP1: Clinical insights for a proliferative and restorative member of the CCN family [0.03%]
WISP1：CCN家族中的一种增殖和修复成员的临床洞察
Kenneth Maiese
Kenneth Maiese
As a proliferative and restorative entity, Wnt1 inducible signaling pathway protein 1 (WISP1) is emerging as a novel target for a number of therapeutic strategies that are relevant for disorders such as traumatic injury, neurodegeneration, ...
Meta-analysis identifies tumor necrosis factor-alpha and interleukin-1 beta as diagnostic biomarkers for bacterial and aseptic meningitis [0.03%]
meta分析发现肿瘤坏死因子α和白细胞介素1β是细菌性和无菌性脑膜炎的诊断生物标志物
Ana Paula Ronzani Panato,Luiza Trajano Tomasi,Carla Sasso Simon et al.
Ana Paula Ronzani Panato et al.
Background: Meningitis is a complex and severe acute infectious disease of the central nervous system and is caused mainly by bacteria and viruses. However, the distinction between aseptic and bacterial meningitis can be ...
Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91(phox) [0.03%]
雌酚在局灶性脑缺血再灌注时的神经保护作用涉及p-Src和gp91(phox)
Wei Yu,Yan Wang,Dang-Xia Zhou et al.
Wei Yu et al.
Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a nonreceptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration...
An enriched population of CD45, CD34 and CD117 stem cells in human umbilical cord blood for potential therapeutic regenerative strategies [0.03%]
具有治疗再生潜力的人脐带血富集的CD45、CD34和CD117干细胞群
Avijit Banik,Sudesh Prabhakar,Jasvinder Kalra et al.
Avijit Banik et al.
Human umbilical cord blood (hUCB) is a primitive source of stem cells and is being banked worldwide for the purpose of future clinical use. Lineage negative (Lin-ve) stem cells are one of the primitive populations in hUCB which are capable ...
Astrocytic and vascular scaffolding for neuroblast migration in the rostral migratory stream [0.03%]
头端迁移流中星形胶质细胞和血管组成的少突胶质前体细胞迁移支架
Marcela Martoncikova,Kamila Fabianova,Andrea Schreiberova et al.
Marcela Martoncikova et al.
New neurons are continuously being added to the olfactory bulb (OB) of adult rodents that are generated in the subventricular zone (SVZ), distant by a few millimeters. Neuronal precursors have to overcome this long distance without the radi...
Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes [0.03%]
血管、氧化和突触包涵体异常在2型糖尿病的发生发展中的作用
Cristina Carvalho,Sonia Catarina Correia,Maria Sancha Santos et al.
Cristina Carvalho et al.
Alterations in brain structure and function are a well-known long-term complication of type 2 diabetes (T2D). Although the mechanism(s) by which T2D lead(s) to cognitive dysfunction and neuronal cells degeneration continue(s) to be a matter...