Rutin and Scopoletin Co-Loaded Niosomes for Intranasal Brain Delivery: Formulation Optimization and Ex Vivo Evaluation [0.03%]
联合装载 Rutin 和 Scopoletin 的非离子胶束鼻用制剂：鼻脑递送的优化与体外评价
Rama Tyagi,Jahanavi Bhar,Neeraj Kumar et al.
Rama Tyagi et al.
Introduction/objective: Rutin (R) and scopoletin (S) are natural flavonols, which have been shown to reduce heart disease, improve blood circulation, reduce inflammation, and even prevent diabetes. Certain physicochemical...
Folic Acid-functionalized Liposomal Covalent Organic Framework for Enhanced Photothermal Cancer Therapy [0.03%]
叶酸功能化光热治疗肿瘤的共价有机框架liposome复合物
Xinying He,Shengli Wan,Qingze Fan et al.
Xinying He et al.
Introduction: ICG suffers from poor photostability and rapid clearance in PTT. This study constructs an FA-modified, pH/NIR responsive COF nanodelivery system for targeted ICG delivery and precise controlled release. ...
Nystatin-Loaded Chitosan Nanoparticles Coated Fabric: A Promising Approach for the Management of Diabetic Foot Fungal Infections [0.03%]
载有尼泊金的壳聚糖纳米颗粒涂层织物：治疗糖尿病足真菌感染的一种前景技术
Fahad Zubair,Muhammad Arfat Yameen,Sanaa Anjum et al.
Fahad Zubair et al.
Introduction: One of the major complications in diabetic patients is foot disease. The microbial infections associated with this condition lead to skin infections, nail disease, and diabetic dermopathy. Nano-coating of te...
Nano-co-delivery Systems Combining Chemical and Photodynamic Therapy against Breast Cancer [0.03%]
用于治疗乳腺癌的化学与光动力联合治疗纳米协同递送系统
Hua Cai,Yi Cen,Nannan Zhao et al.
Hua Cai et al.
Introduction Objective: Combination therapy is considered an effective strategy to improve cancer treatment outcomes. This study aimed to develop a Pluronic F127-based nano-codelivery system (FDC) encapsulating docetaxel (DTX) and chlorin e...
Salvia Miltiorrhiza Nanovesicles: A Strategy to Reprogram Myeloid Cells for Atherosclerosis Therapy via Immune Modulation [0.03%]
纳米红花黄色素药剂：一种通过免疫调节重构髓系细胞治疗动脉粥样硬化的新策略
Hongjun Xu,Rui Zhang,Ruoyu Wu et al.
Hongjun Xu et al.
Introduction: Research has shown that herbal medicine-derived vesicles act as biological agents and drug carriers. This study explores how Salvia miltiorrhiza nanovesicles alleviate atherosclerosis by regulating myeloid c...
Preparation and Characterization of a Low-Molecular-Weight Chitosan Nanoparticle-Based Ocular Formulation for Enhanced Permeation of Timolol Maleate [0.03%]
一种低分子量壳聚糖纳米颗粒基托溴铵眼部制剂的制备及表征以增强马来酸噻吗洛尔渗透性研究
Areen Alshweiat,Sereen Omar Emran,Bashar Altaani et al.
Areen Alshweiat et al.
Introduction/objective: Timolol Maleate (TM) is primarily used to treat glaucoma by reducing intraocular pressure. However, its efficacy is limited by poor ocular bioavailability (
Intelligent Nanomedicine: AI-Driven Smart Carrier Design for Precision Skin Cancer Therapy [0.03%]
智能纳米药物：AI驱动的精准皮肤癌治疗智能载体设计
Nilesh Meshram,Kuldeep Vinchurkar,Laxmikant Borse et al.
Nilesh Meshram et al.
Skin cancer, one of the most common malignancies globally, continues to present major therapeutic hurdles such as limited drug penetration, high systemic toxicity, and tumor recurrence. Nanomedicine has emerged as a powerful approach to ove...
SNEDDS as a Drug Delivery Carrier for BCS Class III and IV Drugs [0.03%]
BCS III和IV类药物的SNEDDS递送系统研究进展
Jyoti Kumari,Dharmendra Kumar,Pramod Kumar Sharma
Jyoti Kumari
Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) are lipid-based systems for drug delivery characterized by poor aqueous solubility and/or limited intestinal permeability, which are overcome by the spontaneous formation of nanosized oil-...
Roxadustat-loaded pH-sensitive Anionic Liposomes Ameliorating Experimental Colitis in Mice: Formulation, Cellular Uptake and In vivo Evaluation [0.03%]
用于改善小鼠实验性结肠炎的罗沙司他载荷型pH敏感阴离子脂质体：制备、细胞摄取及体内评价
Guiping Kong,Yucan Zheng,Yan Lu et al.
Guiping Kong et al.
Introduction: Roxadustat, an inhibitor of hypoxia-inducible factor prolyl hydroxylase, has therapeutic potential for colitis but is limited clinically by poor water solubility and rapid gastrointestinal absorption. This s...
Mechanistic and Phytochemical Basis of Shexiang Xintongning Against Atherosclerosis: Insights from Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接的麝香心通宁防治动脉粥样硬化的机制及植化基础研究
Mengyuan Wang,Guiyun Cao,Xiao Qiu et al.
Mengyuan Wang et al.
Introduction: Shexiang Xintongning (SXN) is a Chinese medicinal compound used to treat cardiovascular diseases and has been formulated into a commercial tablet. Based on Traditional Chinese Medicine (TCM) theory, SXN has ...