Putative Mechanisms of Viral Transmission and Molecular Dysregulation of Mammary Epithelial Cells by Human Papillomavirus: Implications for Breast Cancer [0.03%]
人乳头瘤病毒传播的潜在机制及其对乳腺上皮细胞分子调节障碍的可能与乳腺癌的关系
E G de Lima,C M M do Amaral,F C Q Peixe et al.
E G de Lima et al.
Breast cancer is the most common cancer in women worldwide. Several studies have demonstrated the presence of Human papillomavirus (HPV) DNA in breast cancer samples. However, the role of HPV in breast carcinogenesis is not clear, and the i...
Resistin-Like Molecule-α Causes Lung Injury in Rats with Acute Pancreatitis by Activating the PI-3K/Akt-NF-κB Pathway and Promoting Inflammatory Cytokine Release [0.03%]
Resistin样分子-α通过激活PI-3K/Akt-NF-κB途径和促进炎症细胞因子释放导致急性胰腺炎大鼠肺损伤
W-Y Wang,Y Chen,X Su et al.
W-Y Wang et al.
Background: Resistin-like molecule-α (RELMα) has diverse regulatory functions in inflammation, but its role in severe acute pancreatitis (SAP) and acute pancreatitis associated lung injury (APALI) remains unclear. ...
Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer [0.03%]
睾丸损伤和癌症后的生殖功能恢复的内在因素
A M S Silva,S Correia,S Socorro et al.
A M S Silva et al.
The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a seve...
High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells [0.03%]
高剂量欧米伽-6脂肪酸通过活化JAK2-STAT3信号通路促进胰腺外分泌细胞的细胞因子产生和脂质合成
F Zhu,Y Guan,R Zhang
F Zhu
Background: Linoleic acid has been implicated in the pathogenesis of acute pancreatitis. However, molecular mechanisms underlying adverse effects of large-dose linoleic acid remain unclear. Current study aimed to explore ...
The Emerging Role of Regucalcin as a Tumor Suppressor: Facts and Views [0.03%]
再生钙蛋白作为肿瘤抑制因子的作用机制：事实与观点
C V Vaz,S Correia,H J Cardoso et al.
C V Vaz et al.
Regucalcin (RGN) is a multifunctional protein that was first described as a calcium (Ca2+)-binding protein playing a relevant role in the maintenance of intracellular Ca2+ concentration. However, due to its downregulated expression with agi...
Prostate-Specific G-Protein Coupled Receptor, an Emerging Biomarker Regulating Inflammation and Prostate Cancer Invasion [0.03%]
前列腺特异性G蛋白偶联受体，一个新兴的调节炎症和前列腺癌侵袭的生物标志物
M Rodriguez,S Siwko,M Liu
M Rodriguez
Prostate cancer is highly prevalent among men in developed countries, but a significant proportion of detected cancers remain indolent, never progressing into aggressive carcinomas. This highlights the need to develop refined biomarkers tha...
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity [0.03%]
LASS5与SDHB相互作用，协同抑制p53和p21活性
Z Jiang,F Li,Y Wan et al.
Z Jiang et al.
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role is not yet well understood. A yeast two-hybrid screen was performed using ...
Human Adipose-Derived Stem Cells Delay Retinal Degeneration in Royal College of Surgeons Rats Through Anti-Apoptotic and VEGF-Mediated Neuroprotective Effects [0.03%]
人脂肪组织来源干细胞通过抗凋亡和VEGF介导的神经保护作用延缓皇家外科医学院 rat 视网膜退行性变
Z Li,J Wang,F Gao et al.
Z Li et al.
Stem cell therapy is a promising therapeutic approach for retinal degeneration (RD). Our study investigated the effects of human adipose derived stem cell (hADSCs) on Royal College of Surgeons (RCS) rats. ...
Subpopulations of Bone Marrow Mesenchymal Stem Cells Exhibit Differential Effects in Delaying Retinal Degeneration [0.03%]
骨髓间充质干细胞亚群在延缓视网膜退行性疾病中具有不同的功效
P Li,H Tian,Z Li et al.
P Li et al.
Bone marrow mesenchymal stem cells (BMSCs) have a therapeutic role in retinal degeneration (RD). However, heterogeneity of BMSCs may be associated with differential therapeutic effects in RD. In order to confirm this hypothesis, two subsets...
F Fahs,X-L Bi,F-S Yu et al.
F Fahs et al.
Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of protein-coding genes. Studies have identified microRNAs involved in all phases o...