Fei Yan,Junzheng Yang,Meihua Gong et al.
Fei Yan et al.
Introduction: Pressure ulcers (PUs) are a result of sustained compression of the local skin, leading to impaired blood circulation and subsequent nutritional deficiencies in the skin and subcutaneous tissues. Exosomes are...
Sulfur Dioxide Inhibits TNF-α-induced Photoreceptor Cell Apoptosis Through Sulfenylation of Caspase-3 at Cysteine 163 [0.03%]
二氧化硫通过半胱天冬酶-3的半胱氨酸163位点亚硫酸化抑制肿瘤坏死因子诱导的视杆细胞凋亡
Jiantong Du,Yaqian Huang,Kun Li et al.
Jiantong Du et al.
Introduction/objective: Photoreceptor cell apoptosis contributes significantly to vision loss in retinal degenerative diseases. Gasotransmitter sulfur dioxide (SO2) has been implicated in the regulation of apoptotic proce...
The Synergistic Effect of Nutlin-3a and a Wip1 Inhibitor in Inducing p53 Activity [0.03%]
Nutlin-3a和Wip1抑制剂在诱导p53活性中的协同作用
Ali Hikmat Alburghaif,Hany Akeel Al-Hussaniy,Ali Mahmoud Al-Samydai et al.
Ali Hikmat Alburghaif et al.
Introduction: The p53 protein plays a major role in maintaining genome stability as well as the response of cells to stress. One of the principal things that regulates p53 is MDM2, and the way it interacts with p53 is of ...
A Systematic Review and Meta-Analysis of Immune Signatures Involved in the Prevalence of Exhaustion in Humans, Mice, and Bovine Species [0.03%]
人类、小鼠和牛科动物中引起耗竭流行的免疫特征的系统性综述与元分析
Khushbu Sharma,Shalini Sharma,Shweta Dhanda et al.
Khushbu Sharma et al.
Introduction: Immune exhaustion is known to occur in chronic infections as well as cancer, and is characterized by constant antigenic stimulation and gradual loss of T cell function and upregulation of immune exhaustion m...
Network-based Transcriptomic Profiling of Fetal Astrocyte Differentiation Reveals Therapeutic Targets for Neurodegenerative Disease [0.03%]
基于网络的胎儿星形胶质细胞分化转录组分析揭示了神经退行性疾病的治疗靶点
Arya Moftakhar-Bazkiaei,Maryam Farzaneh
Arya Moftakhar-Bazkiaei
Introduction: Neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD), and Age-related Macular Degeneration (AMD), are marked by the progressive loss of specific neuronal populations. Ast...
Gut Microbiota and Metabolic Profiles Reveal the Mechanism of Weight Loss in Patients with Obesity Stimulated By Acupuncture [0.03%]
肠道菌群和代谢谱揭示肥胖患者针刺减肥机制
Yan Huo,Jianfang Gao,Ying Lv et al.
Yan Huo et al.
Introduction: This study aims to elucidate the mechanisms underlying the efficacy of Quantitative Lifting And Inserting Acupuncture (QLIA) in treating simple obesity through integrated metabolomic and gut microbiota analy...
Overexpression of Membrane Metalloendopeptidase Attenuates Oxidative Stress and Inflammation in Diabetic Neuropathy via the Nrf2/HO-1 Pathway [0.03%]
膜金属内肽酶过表达通过Nrf2/HO-1通路减轻糖尿病神经病变的氧化应激和炎症反应
Zenghui Liu,Jianlin Ge,Jiafeng Sun et al.
Zenghui Liu et al.
Objective: To investigate the role of Membrane Metalloendopeptidase (MME) in oxidative stress and inflammation in painful diabetic neuropathy, and to explore the underlying mechanism. ...
Jun Li,Jinling Pan,Jinjun Wen et al.
Jun Li et al.
Introduction: Gastrointestinal cancers, including esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer, are a major health burden worldwide, characterized by high incidence and mortali...
Development of Integrated Turbidity Spectrophotometric Biosensor System with Osmotic Fragility/DichlorophenolIndophenol Precipitation Assays for Thalassemia Red Blood Cell Screening [0.03%]
用于地中海贫血红细胞筛查的集成浑浊分光光度生物传感器系统与渗透脆性/二氯苯胺吲哚酚沉淀试验的发展
Preeya Pramool,Surakiate Wanram,Kanathip Butchai et al.
Preeya Pramool et al.
Introduction: Thalassemia remains a major public health burden, particularly in low-resource regions where access to advanced laboratory diagnostics is limited. Although high-performance liquid chromatography (HPLC) and c...
Microbiota-driven Immunopathogenesis in Systemic Lupus Erythematosus: Cross-site Mechanisms and Intervention Strategies [0.03%]
系统性红斑狼疮中的微生物群驱动的免疫病理发生：跨部位机制与干预策略
Shuqing Feng,Qin Huang
Shuqing Feng
Systemic lupus erythematosus (SLE) is a complex autoimmune disease whose pathogenesis involves intricate interactions with the human microbiota. Accumulating evidence reveals significant compositional and functional dysbiosis in the gut, or...