Adiponectin Ameliorates Intrauterine Adhesion-Related Endometrial Inflammation and Fibrotic Changes by Downregulating the NLRP3/IL-1β/TGF-β1 Axis [0.03%]
脂联素通过下调NLRP3/IL-1β/TGF-β1轴改善宫腔粘连相关的子宫内膜炎症和纤维化变化
Wenmei Yang,Qiaoxia Li,Yongyan Zhang et al.
Wenmei Yang et al.
Introduction: Intrauterine Adhesions (IUA), a common gynecological condition often caused by infection or endometrial injury, significantly impact women's reproductive and mental health. Its unclear pathogenesis hinders t...
Andras Guttman
Andras Guttman
Exposure to Stress or an Enriched Environment in Youth Modulates Prenatal Inflammation-Induced Cognitive Deficits in Mice and Is Associated with Hippocampal SNAP-25 Expression Levels [0.03%]
青年期压力或环境富足经历可调节小鼠产前炎症诱导的认知缺陷并影响脑源性神经营养因子的表达水平
Yong-Fang Wu,Lei Cao,Li-Ping Zeng et al.
Yong-Fang Wu et al.
Introduction: Brain aging can promote neuronal damage, contributing to aging-associated memory impairments (AAMI), a phenomenon characteristic of normal aging. However, it remains unclear whether and how exposure to stres...
Therapeutic Potential of Vericiguat in Myocardial Ischemia/ Reperfusion Injury: Crosstalk between Heat Shock Protein 90 and Complement Activation [0.03%]
维卡瓜特治疗心肌缺血/再灌注损伤的潜力：热休克蛋白90与补体激活的相互作用
Junyan Chen,Sijie Pan,Dongxiao Wang et al.
Junyan Chen et al.
Introduction: The present study aimed to examine the functions of heat shock protein 90 (HSP90), NF-κB, C3, and C5a in cardioprotective effects induced by vericiguat in mice. ...
Causal Relationship Between Plasma Protein-to-Protein Ratios and Rheumatoid Arthritis: A Proteome-wide Mendelian Randomization Study [0.03%]
蛋白比值与类风湿性关节炎的因果关系：基于蛋白质组范围的孟德尔随机化研究
Mingyue Yan,Kehao Hou,Tianrui Wang et al.
Mingyue Yan et al.
Introduction: The causal relevance of circulating plasma protein-to-protein ratios (PPRs) in Rheumatoid Arthritis (RA) remains unclear. We employed Mendelian Randomization (MR) to investigate this relationship. ...
Effects of the Total Flavonoids from Drynaria on Methyltransferase METTL3 and the Coupling of Osteogenesis and Angiogenesis in a Bone Defect Rat Model [0.03%]
干燥杜仲中的总黄酮通过调控METTL3促进骨缺损模型中成骨和血管化的耦合效应
Jie Wu,Jingqi Zeng,Ruizhe Wu et al.
Jie Wu et al.
Introduction: This study aimed to investigate the effects of the Total Flavonoids from Rhizoma Drynaria (TFRD) on METTL3-mediated m6A methylation and osteogenic-angiogenic coupling during the repair of large bone defects ...
Exosome-Based Regulation and Therapy in Osteoporosis: Mechanistic Insights and Translational Advances [0.03%]
外泌体在骨质疏松症调控和治疗中的机制及转化研究进展
Yuyang Luo,Shanshan Li,Xin Jin
Yuyang Luo
Osteoporosis is a chronic and progressive skeletal disease characterized by decreased bone mass and microarchitectural deterioration, leading to increased fracture susceptibility. Emerging evidence suggests that extracellular vesicles, part...
CDK12 as a Potential Biomarker for Characterization of Circulating Tumor Cells in Epithelial Ovarian Tumors [0.03%]
CDK12可作为上皮性卵巢肿瘤循环肿瘤细胞表征的潜在生物标志物
Shazia Jabbar,Nazia Ahmed,Jahan Ara Hasan et al.
Shazia Jabbar et al.
Introduction: The utility of epithelial markers is limited for the detection of circulatory tumor cells in patients with epithelial ovarian tumors, as these markers do not relate to clinicopathological characteristics nor...
Swaroop Kumar Pandey,Ayush Kulshreshtha,Anuja Mishra
Swaroop Kumar Pandey
The One Health concept emphasizes the complex connection between environmental, animal, and human health and calls for cross-sectoral cooperation to improve ecological integrity and advance world health. The need for coordinated, preventati...
Regulatory Mechanisms of CHD7 and PAX4 Gene Mutations on Proliferation and Apoptosis in Chondrocytes [0.03%]
CHD7和PAX4基因突变调控软骨细胞增殖及凋亡的机制研究
Feng Xu,Yiyuan Li,Datao Li et al.
Feng Xu et al.
Introduction: Mutations in Chromodomain Helicase DNA Binding Protein 7 (CHD7) and Paired Box Gene 4 (PAX4) are critical for normal cartilage development and are implicated through their impact on chondrocyte functions. Th...