Next-Generation Nucleic Acid Delivery: A Review of Nanobiosystem Design and Applications [0.03%]
下一代核酸递送：纳米生物系统设计及应用综述
Ashish Kumar Parashar,Anu Hardenia,Sunil Kumar Dwivedi et al.
Ashish Kumar Parashar et al.
The increasing approval of nucleic acid therapeutics has led to a significant advancement in medicines, demonstrating their potential to revolutionize the prevention and treatment of numerous diseases. However, challenges like nuclease degr...
Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era of CHK1 Inhibition and Personalized Treatments [0.03%]
针对癌症中的细胞外染色体DNA（ecDNA）：新的 CHK1 抑制和个性化治疗时代来临
Komal,Lovekesh Singh,Subramanyam Sarma Ganti
Komal
Elucidating the Predominant Role of AEBP1 in Different Types of Cancers with a Focus on Glioblastoma Progression - A Review [0.03%]
AEBP1在不同类型的癌症中的主导作用及其在胶质母细胞瘤进展中的作用——综述
Rangaraj Kaviyaprabha,Sridhar Muthusami,Thandaserry Vasudevan Miji et al.
Rangaraj Kaviyaprabha et al.
Introduction: Glioblastoma multiforme (GBM) is a highly deleterious lesion with an increased recurrence rate even after radiotherapy and chemotherapy. In this context, additional biomarkers are needed to curb chemoresista...
Exploring Gene Therapy: The Next Generation of Colorectal Cancer Treatment [0.03%]
探索基因疗法：下一代结直肠癌治疗方案
Raj Kamal,Priyanka Paul,Diksha et al.
Raj Kamal et al.
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma [0.03%]
肺癌腺癌氨基酸代谢相关生物标志物的识别验证及其潜在机制研究
Xu Zhu,Ying Zhang,Peiying Pan et al.
Xu Zhu et al.
Background: In lung adenocarcinoma (LUAD), the metabolism of amino acids (AAs) plays a crucial role in the growth, infiltration, and metastasis of tumor cells. Nevertheless, the potential of AA metabolism-associated genes...
Imaged Capillary Isoelectric Focusing (icIEF) Platform for Characterization of Charge Variants of Adeno-Associated Virus (AAV) Capsids and Impact on Their Transduction Efficiency [0.03%]
用于表征腺相关病毒衣壳电荷异构体并研究其对转导效率影响的成像毛细管等电聚焦平台(icIEF)
Brandon Hoyle,Dhimiter Bello,Jonathan Hill et al.
Brandon Hoyle et al.
Objective: Adeno-Associated Virus (AAV) vectors are comprised of a capsid protein encapsulating a Deoxyribonucleic Acid (DNA) transgene that has been used in the gene therapy field showing potential to treat a range of ge...
Non-coding RNAs-based Therapy and Angiogenesis: A New Era for the Management of Gliomas [0.03%]
基于非编码RNA的治疗和血管生成：胶质瘤管理的新时代
Ozal Beylerli,Ilgiz Gareev,Elmar Musaev et al.
Ozal Beylerli et al.
The relentless pursuit of understanding and combating glioblastoma (GBM), one of the most formidable foes in the realm of cancer, requires a deeper exploration of its intricate dynamics. Gliomas, particularly GBM, are known for their lethal...
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance [0.03%]
下一代外显子组模式：先进方法及临床意义
Sumel Ashique,Anas Islam,Navjot Kaur Sandhu et al.
Sumel Ashique et al.
NGS (Next-generation sequencing) has emerged as the primary approach for gene finding in uncommon hereditary disorders. Targeted gene panels, whole genome sequencing (WGS), and whole exome sequencing (WES) are uses of next-generation sequen...
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies [0.03%]
基于CRISPR/Cas9技术的嵌合抗原受体T细胞免疫检查点修饰疗法在血液系统恶性肿瘤中的应用研究
Forough Shams,Elham Sharif,Hajar Abbasi-Kenarsari et al.
Forough Shams et al.
Hematologic malignancies, which arise from dysregulation of hematopoiesis, are a group of cancers originating in cells with diminished capacity to differentiate into mature progeny and accumulating immature cells in blood-forming tissues su...
Transforming RNA-Based Gene Therapy with Innovative Nanocarriers for siRNA and miRNA Delivery [0.03%]
用于siRNA和miRNA传递的创新型纳米载体转化基于RNA的基因治疗
Jitendra Singh Chaudhary,Dilip Kumar Chanchal,Kuldeep Singh et al.
Jitendra Singh Chaudhary et al.
The cells have been given precise instructions proprio to the regulation of gene expression by the main genesis of Ryan-based gene therapy, which has revived cancer treatment and other disorders. The difficulty of delivering small interferi...