Identification of Key Features Pivotal to the Characteristics and Functions of Gut Bacteria Taxa through Machine Learning Methods [0.03%]
基于机器学习方法鉴别肠道菌群类群的关键特征及功能
ZhanDong Li,QingLan Ma,Hao Li et al.
ZhanDong Li et al.
Background: Gut bacteria critically influence digestion, facilitate the breakdown of complex food substances, aid in essential nutrient synthesis, and contribute to immune system balance. However, current knowledge regard...
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68 [0.03%]
基于免疫信息学的针对肠道病毒D68的免疫增强及非过敏性多表位亚单位疫苗的设计
Muhammad Suleman,Safir Ullah Khan,Hina Jabeen et al.
Muhammad Suleman et al.
Introduction: Enterovirus D68 (EV-D68) is a non-enveloped, positive-sense, singlestranded RNA virus known for causing severe respiratory illnesses and its association with acute flaccid myelitis (AFM) in children. Despite...
Review Deciphering the Anticancer Efficacy of Oroxylin A Targeting Dysregulated Oncogenes [0.03%]
评论：解读 oroxylin a 目标失调癌基因的抗癌功效
Pratibha Pandey,Subbulakshmi Ganesan,Sumit Rajotiya et al.
Pratibha Pandey et al.
Flavonoids exhibit anti-tumor properties against many human cancer cells, indicating their potential as effective anticancer medicines. Oroxylin A (OrA) is a monoflavonoid molecule that shows significant promise against several types of can...
Guanyu Wang,Song Yan,Luyang Zhang et al.
Guanyu Wang et al.
Introduction: Aggressive Pituitary Neuroendocrine Tumors (PitNETs) pose significant therapeutic challenges due to their invasive behavior and resistance to conventional therapies. Current prognostic markers lack the abili...
Identification of Novel Biomarkers of Bacterial Lipopolysaccharides in Diabetic Nephropathy via Transcriptomics and Mendelian Randomization [0.03%]
通过转录组学和孟德尔随机化识别糖尿病肾病中细菌脂多糖的新生物标志物
Yaxian Ning,Jianqin Wang,Xiaochun Zhou et al.
Yaxian Ning et al.
Background: Dysbiosis of Intestinal Flora Lipopolysaccharides (LPS) is implicated in Diabetic Nephropathy (DN), yet the underlying mechanisms remain unclear. This study aims to elucidate the causal relationship between ba...
The Genetic and Epidemiological Dimensions of Gallbladder Cancer: Toward Effective Therapeutic Strategies [0.03%]
胆囊癌的遗传学和流行病学维度：有效的治疗策略展望
Afrin Siddiqui,Somali Sanyal,Debalina Mukherjee et al.
Afrin Siddiqui et al.
Gallbladder Cancer (GBC) is a highly concerning malignancy, particularly prevalent in the Asian continent, attributed to irregularities in the bile tract. As of 2022, GLOBOCAN data ranks GBC as the 22nd most common cause of cancer-related m...
Advancements in Targeted Therapies and Pharmacogenomics for Personalized Breast Cancer Treatment: The Role of Gene SNPs in Treatment Resistance [0.03%]
乳腺癌个性化治疗的靶向疗法和药物基因组学进展：基因SNP在耐药中的作用
Devika Tripathi,Neal M Davies,P S Rajinikanth et al.
Devika Tripathi et al.
Breast cancer remains a prevalent and diverse disease, significantly contributing to cancer- related deaths among women worldwide. Recent advancements in molecular biology have paved the way for targeted therapies and pharmacogenomics, whic...
Bridging Mind and Gut: The Molecular Mechanisms of microRNA, Microbiota, and Cytokine Interactions in Depression [0.03%]
沟通心与肠：抑郁状态下microRNA、微生物群和细胞因子相互作用的分子机制
Himanshu Sharma,Abdullah Al Noman,Iftakhar Ahmad et al.
Himanshu Sharma et al.
Depression is a complex psychiatric disorder that arises from various underlying biological mechanisms. In this review, the role of microRNAs (miRNAs) in modulating gut microbiotacytokine communication and their potential to unravel the pat...
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus in Mouse Models of Breast Cancer [0.03%]
携带肠病毒的间充质干细胞在乳腺癌小鼠模型中的治疗作用
Fatemeh Aminian,Nahid Babaei,Hadi Esmaeili Gouvarchin Ghaleh et al.
Fatemeh Aminian et al.
Introduction: Breast Cancer (BC) is treatable in early stages but has high mortality rates in advanced cases, highlighting the need for better treatment methods. Oncolytic Viruses (OVs) have emerged as a promising approac...
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool [0.03%]
基于CRISPR/Cas9编辑工具的体外AFP基因敲除对肝癌HepG2细胞p53/bcl2/caspase-3调控的新视角研究
Fatma Khorshed,Amina M Medhat,Germine M Hamdy et al.
Fatma Khorshed et al.
Introduction: Hepatocellular carcinoma (HCC) is a major health burden worldwide, with a persistent need for molecular target drugs. Alpha-fetoprotein (AFP) is a major concern during HCC, as it has an incompletely solved a...