5-Alpha Reductase Deficiency - An Uncommon Disorder of Sexual Development: A Case Study of Four Turkish Patients within a Family [0.03%]
5α还原酶缺乏症：一种罕见的性发育障碍：一个土耳其家庭四例患者的病例研究
Ali Örs,Muhammed Burak Bereketoğlu,Asli Boz et al.
Ali Örs et al.
Introduction: 5-alpha reductase deficiency is an inherited autosomal recessive disorder that can present with severe masculinization defects and ambiguous genitalia. Up to more than 100 mutations have been reported, but p...
Precision Medicine: Design of Immune-Inert Exosomes for Targeted Gene Delivery [0.03%]
精准医学：免疫惰性外泌体的制备及其靶向基因递送功能研究
Fawzy A Saad
Fawzy A Saad
Exosomes represent the smallest size among extracellular vesicles, which also include apoptotic bodies and microvesicles. Exosomes are natural nanocarriers that play a key role in intracellular communication, consisting of a hydrophobic lip...
A Comprehensive Review of Genetic Risk Factors for Alzheimer's Disease Development [0.03%]
阿尔茨海默病发病的遗传危险因素综述
Aniket Kakkar,Harpreet Singh,Amit Anand et al.
Aniket Kakkar et al.
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder with a complex genetic basis involving both rare mutations and common variants. This review provides a comprehensive synthesis of established and emerging genetic risk fac...
Advancing Antibacterial Strategies: CRISPR-Phage-Mediated Gene Therapy Targeting Bacterial Resistance Genes [0.03%]
推进抗菌策略：CRISPR-噬菌体介导的靶向细菌抗性基因的基因治疗
Arvind Kumar Patel,Neha Singh,Neetu Sachan et al.
Arvind Kumar Patel et al.
One of the most significant issues facing the world today is antibiotic resistance, which makes it increasingly difficult to treat bacterial infections. Regular antibiotics no longer work against many bacteria, affecting millions of people....
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines [0.03%]
EGCG与杨梅素对ME180和SiHa细胞系宫颈癌生物标志物的协同抗增殖作用
Kaviyaprabha Rangaraj,Miji Thandaserry Vasudevan,Suseela Rangaraj et al.
Kaviyaprabha Rangaraj et al.
Introduction: Identifying potential biomarkers for the detection, diagnosis, and monitoring of cervical cancer (CC) constitutes a key area for future research. ...
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology [0.03%]
利用scPagwas方法学鉴定ARRB2作为胰腺癌预后生物标志物和肿瘤微环境中的关键因素
Gaonan Tian,Chengcheng Liu,Chang Che et al.
Gaonan Tian et al.
Introduction: Pancreatic Cancer (PC) is recognized as a highly aggressive malignancy and is anticipated to become the second leading cause of cancer-associated deaths across the United States by 2030. Owing to its late-st...
Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions [0.03%]
基因治疗单基因病背景下解析家族性脑海绵状血管畸形的病因及治疗意义
Ke Ma,Moksada Regmi,Shikun Liu et al.
Ke Ma et al.
Cerebral Cavernous Malformations (CCMs) are vascular anomalies in the central nervous system that arise from both genetic and non-genetic factors, and can cause hemorrhage, seizures, and neurological deficits. Approximately 80% of CCMs are ...
Amita Joshi Rana,Md Sadique Hussain,Vikas Jakhmola et al.
Amita Joshi Rana et al.
Gene therapy has revolutionized the therapeutic landscape for hemophilia A and B, offering the prospect for persistent endogenous production of coagulation factors VIII and IX. Recent advances in adeno-associated virus (AAV)-mediated gene t...
Tailored Therapies for Hereditary Diabetes: Unraveling the Genetic Underpinnings of MODY and Neonatal Diabetes [0.03%]
遗传性糖尿病的个性化治疗：解密MODY和新生儿糖尿病的遗传基础
Jyotsana Dwivedi,Shubhi Kaushal,Pranay Wal et al.
Jyotsana Dwivedi et al.
Introduction: Hereditary forms of diabetes, including Maturity-Onset Diabetes of the Young (MODY) and Neonatal Diabetes Mellitus (NDM), are rare monogenic disorders caused by mutations in genes involved in pancreatic deve...
Targeted Therapies and Computational Approaches in the Management of Crohn's Disease [0.03%]
克罗恩病管理中的靶向治疗及计算方法
Ajay Kumar Pandey,Sayali Mukherjee
Ajay Kumar Pandey
Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract, presents significant challenges in clinical medicine due to its multifactorial etiology and varied therapeutic responses. This review examines the diverse ...