CFTR mRNA-Based Gene Therapy for Cystic Fibrosis: A Mutation-Agnostic Strategy to Restore Ion Transport Function [0.03%]
用于囊性纤维化的CFTR mRNA基基因疗法：一种恢复离子转运功能的突变无关策略
Jayendra Kumar,Mehetre Dattatraya Martand,Arpan Kumar Tripathi et al.
Jayendra Kumar et al.
Cystic fibrosis is a severe autosomal recessive disorder caused by mutations in the CFTR gene, leading to dysfunctional chloride ion transport across epithelial cells. This results in the accumulation of thick, sticky mucus, primarily affec...
Decoding Programmed Cell Death Genes: Innovations in Cancer Diagnosis and Treatment [0.03%]
解读程序性细胞死亡基因：癌症诊断和治疗的创新方法
Aman Kumar,Balak Das Kurmi
Aman Kumar
Programmed cell death (PCD) profoundly influences cancer initiation, progression, and therapeutic response through interconnected pathways such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis. This perspective summarizes r...
Vatan Chaudhary,Atul Pratap Singh,Himanchal Sharma et al.
Vatan Chaudhary et al.
Introduction: CRISPR-Cas9 enables precise genome editing but faces delivery challenges, including poor cellular uptake, off-target effects, and immune activation. Focused ultrasound (FUS) and nanotechnology-based carriers...
Challenges in the Stability, Safety, and Efficacy of Antisense Oligonucleotide Therapeutics [0.03%]
反义寡核苷酸药物的稳定性、安全性和有效性的挑战分析
Mohini Santosh Jamadade,Rashmi Bhushan,Sakshi Ramesh Mahadik et al.
Mohini Santosh Jamadade et al.
Antisense oligonucleotides represent a promising class of therapeutic agents due to their high specificity in modulating gene expression. These short, single-stranded synthetic sequences (typically 13-25 nucleotides) function by binding to ...
Gene Therapy for Hemophilia: Innovations, Milestones, and Future Prospects [0.03%]
遗传性血友病的基因治疗：创新、里程碑和未来前景
Dinesh Kumar,Vrinda Gupta,Rajni Tanwar et al.
Dinesh Kumar et al.
Haemophilia, a genetic bleeding disorder predominantly affecting males, arises from deficiencies or dysfunctions in clotting factors VIII or IX. Conventional treatments, such as frequent intravenous infusions of clotting factor concentrates...
Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review [0.03%]
探究慢性疾病表观遗传机制：综述性研究
Afaf Aldahish,Rajalakshimi Vasudevan,Shaima Y Al Qasim et al.
Afaf Aldahish et al.
Epigenetics, the study of heritable changes in gene expression without changes to the DNA sequence, has emerged as an important regulator of disease risk and development. Epigenetic alterations, such as DNA methylation, histone modification...
Molecular Complexities of Dementia: PAISA Mutations and Targeting TAF2N as Therapeutic Avenues [0.03%]
痴呆的分子复杂性：PAISA突变和靶向TAF2N作为治疗途径
Siva Prasad Panda,Sanjesh Kumar,Mansi Singh et al.
Siva Prasad Panda et al.
Millions of individuals worldwide are affected by Alzheimer's disease dementia (ADD) and frontotemporal dementia (FTD), with FTD characterized by degeneration of the frontal and temporal lobes leading to cognitive and behavioral impairments...
Vandana Soni
Vandana Soni
Mitochondrial dysfunction and the Warburg effect, characterized by aerobic glycolysis, are hallmarks of cancer metabolism, facilitating tumor progression and resistance to therapies. These metabolic shifts allow cancer cells to prioritize g...
Folic Acid-Conjugated Nanocarriers for Targeted Cancer Therapy: Recent Patents and Future Prospects [0.03%]
叶酸偶联的纳米载体用于癌症靶向治疗：近期专利和未来前景
Nandini Sharma,Yukta Garg,Raj Kumar Narang et al.
Nandini Sharma et al.
As folate receptors are overexpressed on the surface of many tumor cells, folic acidconjugated nanocarriers have emerged as a promising approach for targeted cancer therapy. These nanocarriers enhance therapeutic efficacy while reducing sys...
Revolutionizing Drug and Gene Delivery: Cutting-Edge Smart Polymers for Precision Release [0.03%]
精准释放的智能聚合物药物基因递送行业变革者
Atul Pratap Singh,Shamim,Dhananjay Taumar et al.
Atul Pratap Singh et al.
Smart polymer-based drug and gene delivery systems are revolutionizing contemporary therapeutics with their increased specificity, efficacy, and safety. Compared to traditional carriers, smart polymers exhibit stimuli-responsive behavior, e...