Theranostic Potential of Bacteriophages against Oral Squamous Cell Carcinoma [0.03%]
噬菌体在口腔鳞状细胞癌诊疗中的潜力
Maheswaran Easwaran,Sivagnanavelmurugan Madasamy,Baskar Venkidasamy
Maheswaran Easwaran
Oral Squamous Cell Carcinoma (OSCC) is a widespread and challenging disease that accounts for 94% of cancers of the oral cavity worldwide. Bacteriophages (phages) have shown promise as a potential theranostic agent for the treatment of OSCC...
Aya Al Othman,Anna Polyanskaya,Mikhail Durymanov
Aya Al Othman
An analysis of mammalian genomes has revealed a significant number of DNA sequences with transposon or viral origin. Some of these elements encode functional proteins, repurposed during evolution to play significant physiological roles in c...
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis [0.03%]
单剂量AAV2-FGF18基因治疗减少机械诱导骨关节炎软骨丢失和软骨下骨损伤
Judith M Hollander,Alex Goraltchouk,Jingshu Liu et al.
Judith M Hollander et al.
Background: Osteoarthritis (OA) is a highly debilitating, degenerative pathology of cartilaginous joints affecting over 500 million people worldwide. The global economic burden of OA is estimated at $260-519 billion and g...
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis [0.03%]
沉默AEG-1从Balb/c小鼠到大数据分析的结肠癌治疗新靶点AEG-1研究
Sushmitha Sriramulu,Sarubala Malayaperumal,Antara Banerjee et al.
Sushmitha Sriramulu et al.
Background: Astrocyte elevated gene-1 (AEG-1) is overexpressed in various malignancies. Exostosin-1 (EXT-1), a tumor suppressor, is an intermediate for malignant tumors. Understanding the mechanism behind the interaction ...
Catechin Protects against Lipopolysaccharide-induced Depressive-like Behaviour in Mice by Regulating Neuronal and Inflammatory Genes [0.03%]
儿茶素通过调节神经元和炎症基因保护小鼠免受脂多糖诱导的类似抑郁的行为
Yanfang Su,Ping Qiu,Li Cheng et al.
Yanfang Su et al.
Background: Many studies have suggested that tea has antidepressant effects; however, the underlying mechanism is not fully studied. As the main anti-inflammatory polyphenol in tea, catechin may contribute to the protecti...
SLC2A3 is a Potential Factor for Head and Neck Squamous Cancer Development through Tumor Microenvironment Alteration [0.03%]
SLC2A3通过改变肿瘤微环境成为头颈鳞状细胞癌的潜在致癌因素
Wei Jiang,Sheng Xu,Ping Li
Wei Jiang
Introduction: Tumor immunity has garnered increasing attention in cancer treatment and progression. However, there is still a challenge in understanding the mechanisms of specific molecules affecting the clinical prognosi...
Lipid-Based Nanocarriers for Targeted Gene Delivery in Lung Cancer Therapy: Exploring a Novel Therapeutic Paradigm [0.03%]
肺癌治疗中基于脂质的纳米递送系统介导基因药物精准传递的研究进展与发展前景
Anahita Beigi,Seyed Morteza Naghib,Amir Matini et al.
Anahita Beigi et al.
Lung cancer is a significant cause of cancer-related death worldwide. It can be broadly categorised into small-cell lung cancer (SCLC) and Non-small cell lung cancer (NSCLC). Surgical intervention, radiation therapy, and the administration ...
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders [0.03%]
基于CRISPR的基因调控疗法在神经退行性疾病中的进展
Bharat Bhushan,Kuldeep Singh,Shivendra Kumar et al.
Bharat Bhushan et al.
: Neurodegenerative disorders pose significant challenges in the realm of healthcare, as these conditions manifest in complex, multifaceted ways, often attributed to genetic anomalies. With the emergence of CRISPR (Clustered Regularly Inter...
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer [0.03%]
通过分析克罗恩病和结直肠癌中T细胞免疫反应解析肠道免疫稳态的机制
Tianming Jiang,Jie Zheng,Nana Li et al.
Tianming Jiang et al.
Introduction: Crohn's disease (CD) and colorectal cancer (CRC) represent a group of intestinal disorders characterized by intricate pathogenic mechanisms linked to the disruption of intestinal immune homeostasis. Therefor...
Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells [0.03%]
非编码RNA在肿瘤细胞放疗敏感性及耐受性中的作用
Fatemeh Jalali-Zefrei,Seyed Mehdi Mousavi,Kourosh Delpasand et al.
Fatemeh Jalali-Zefrei et al.
Radiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of...