miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement [0.03%]
靶向microRNA的疫苗：病毒减毒和免疫原性增强的 promising 方法
Abhijit Debnath,Rupa Mazumder,Avijit Mazumder et al.
Abhijit Debnath et al.
MicroRNAs (miRNAs) have emerged as a significant tool in the realm of vaccinology, offering novel approaches to vaccine development. This study investigates the potential of miRNAs in the development of advanced vaccines, with an emphasis o...
Mingyang Yue,Rong Jia
Mingyang Yue
Alternative splicing (AS) of pre-mRNA occurs widely in human genes to produce multiple isoforms with different or even opposite functions. Aberrant AS is often associated with gene mutations and can be corrected by gene therapy. Oral diseas...
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats [0.03%]
牛乳转铁蛋白对创伤修复过程中多器官功能障碍大鼠铁稳态及基因表达变化的影响
Ahmet Sarper Bozkurt,Şenay Görücü Yılmaz
Ahmet Sarper Bozkurt
Background: Injury systemically disrupts the homeostatic balance and can cause organ failure. LF mediates both iron-dependent and iron-independent mechanisms, and the role of LF in regulating iron homeostasis is vital in ...
Biogenesis and Function of circRNAs in Pulmonary Fibrosis [0.03%]
圆环状RNA（circRNA）在肺纤维化发病机制中的生物发生及功能研究
Songzi Zhang,Wenjie Hu,Changjun Lv et al.
Songzi Zhang et al.
Pulmonary fibrosis is a class of fibrosing interstitial lung diseases caused by many pathogenic factors inside and outside the lung, with unknown mechanisms and without effective treatment. Therefore, a comprehensive understanding of the mo...
The Functions and Application Prospects of Hepatocyte Growth Factor in Reproduction [0.03%]
肝细胞生长因子在生殖方面的功能和应用前景
Xin Mi,Caiyi Chen,Chen Feng et al.
Xin Mi et al.
Hepatocyte growth factor (HGF) is expressed in multiple systems and mediates a variety of biological activities, such as mitosis, motility, and morphogenesis. A growing number of studies have revealed the expression patterns and functions o...
Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873-SOX4 Axis [0.03%]
hsa_circ_0102231敲低通过miR-873-SOX4轴抑制肝癌进展
Jingyu Qian,Banghong Jiang,Zhongqiang Qin et al.
Jingyu Qian et al.
Background: Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Aim: ...
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma [0.03%]
肺腺癌中核糖核苷二磷酸还原酶M2亚基的意义研究
Xiao-Jun Wang,Yun-Xia Huo,Peng-Jun Yang et al.
Xiao-Jun Wang et al.
Introduction: The Ribonucleoside-diphosphate Reductase subunit M2 (RRM2) is known to be overexpressed in various cancers, though its specific functional implications remain unclear. This aims to elucidate the role of RRM2...
Acetylresveratrol (AC-Res): An Evolving Frontier in Modulating Gene Expression [0.03%]
乙酰化白藜芦醇（AC-Res）：一种调节基因表达的新前沿领域
Uttam Prasad Panigrahy,Rahul Subhash Buchade,Sandhya S et al.
Uttam Prasad Panigrahy et al.
Background: Acetylresveratrol (AC-Res), to date, is a powerful stilbene phytoalexin generated organically or as a component of a plant's defensive system, is a significant plant phenolic chemical portion and is investigat...
The Role and Treatment Strategies of Ammonia-Related Metabolism in Tumor Microenvironment [0.03%]
肿瘤微环境中与氨相关代谢的作用及治疗策略
Qizhen Ye,Dan Li,Yi Zou et al.
Qizhen Ye et al.
Tumor cells achieve their adaptability through various metabolic reprogramming processes. Among them, ammonia, as a traditional metabolic waste, plays an increasingly important role in the tumor microenvironment along with its associated me...
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma [0.03%]
单细胞和bulk转录组分析揭示了肝癌患者临床预后及免疫治疗反应相关的干性和昼夜节律紊乱标志物签名
Xiaojing Zhu,Zixin Zhang,Jiaxing Zhang et al.
Xiaojing Zhu et al.
Aims: Investigating the impact of stemness-related circadian rhythm disruption (SCRD) on hepatocellular carcinoma (HCC) prognosis and its potential as a predictor for immunotherapy response. ...