Single-cell Transcriptomics Inference of Neutrophil-mast Cell Communication Programs in Periodontitis [0.03%]
单细胞转录组学推理出牙周炎中性粒细胞-肥大细胞通讯程序
Lina Liu,Miaomiao Xue
Lina Liu
Introduction: Neutrophil dysregulation is one of the main features of periodontitis (PD). This study delineated neutrophil heterogeneity and predicted potential communication of mast cells within the microenvironment of P...
GULP1 in Ovarian Cancer: Expression, Biological Function, and Clinical Significance [0.03%]
卵巢癌中的GULP1：表达、生物学功能和临床意义
Zongzong Sun,Xinjun Hu,Di Huang et al.
Zongzong Sun et al.
Introduction: As an engulfment adapter for apoptotic clearance, GULP1 is related to tumor progression, but its role in ovarian cancer (OVCA) remains unclear. ...
Single‑cell Transcriptomic Profiling of Bone Marrow Mesenchymal Stem Cells Reveals Lineage Heterogeneity and Dysregulated Osteoblast Genes in Osteoporosis Versus Osteoarthritis [0.03%]
单细胞转录组分析骨髓间充质干细胞揭示了骨质疏松症和骨关节炎中成骨细胞基因的异质性及失调状况
Houlei Wang,Chenyang Zhuang,Tianle Ma et al.
Houlei Wang et al.
Introduction: Osteoporosis (OP) and osteoarthritis (OA) are two skeletal disorders characterized by disrupted bone homeostasis. Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has emerged as a promising th...
Surface Functionalization of 3D-Printed Porous Ti-6Al-4V Scaffolds with PDA‑mHA-Col I Composite Coating Drives Macrophage Polarization toward the M2 Phenotype and Promotes Immunomodulation: An In Vitro Study [0.03%]
基于PDA-mHA-Col I复合涂层的功能化3D打印多孔Ti-6Al-4V支架驱动巨噬细胞极化为M2表型并促进免疫调节：体外研究
Xu Han,Hailong Yuan,Yi Xiao et al.
Xu Han et al.
Objective: To devise a bioactive surface functionalization approach for 3D-printed Ti- 6Al-4V scaffolds that influences macrophage polarization towards the pro-reparative M2 phenotype, therefore enhancing immunomodulation...
Screening and Functional Study of Biomarkers Related to Cell-in-cell Structure in Stomach Adenocarcinoma [0.03%]
胃腺癌细胞内包涵体相关生物标志物的筛选及功能研究
Xiangjie Fang,Xinyu Gu,Dong Hou et al.
Xiangjie Fang et al.
Introduction: A comprehensive study of Cell-In-Cell (CIC) structures in stomach adenocarcinoma (STAD) may facilitate the development of therapeutic strategies. ...
HOXC4 Is Associated with the Prognosis and Immune Cell Infiltration in the Progression of Prostate Cancer [0.03%]
HOXC4与前列腺癌进展中的预后和免疫细胞浸润相关
Zhenhong Chen,Dujuan Wang,Yongkang Xie et al.
Zhenhong Chen et al.
Introduction: Members of the Homeobox (HOX) gene family, particularly HOXCs, may be implicated in the development and prognosis of prostate cancer (PCa), but the specific mechanisms remain unclear. ...
Identification of Potential Biomarkers in Autism: PRELID2, MYO1B, LRCH2, LIFR, and RERG May Serve as Regulators in Synaptic Membrane-Integrating Interneurons [0.03%]
自闭症潜在生物标志物的识别：PRELID2、MYO1B、LRCH2、LIFR和RERG可能是突触膜整合中间神经元的调节因子
Wei Zhang,Chenyang Wang,Xiaoqian Zhao et al.
Wei Zhang et al.
Background: Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental condition. Single-cell RNA sequencing (scRNA-seq) has revealed transcriptional disruptions, particularly in interneurons, yet their s...
APOL3 Orchestrates Metastasis and Enzalutamide Resistance via STAT3-DAB2IP Signaling in Prostate Cancer [0.03%]
APOL3通过STAT3-DAB2IP信号转导在前列腺癌中调控转移和恩杂鲁胺耐药性
Quanxin Wang,Songlin Zuo,Lin Chen et al.
Quanxin Wang et al.
Background: In advanced Prostate Cancer (PCa), metastatic spread and the inevitable emergence of enzalutamide resistance represent major clinical hurdles. Although apolipoprotein L3 (APOL3) is linked to oncogenesis, its p...
A Telomere-Maintenance Three-Gene Model for the Prognostic Prediction in Intrahepatic Cholangiocarcinoma and Multi-Cohort Validation [0.03%]
一种用于预测肝内胆管癌预后的端粒维持三基因模型及多队列验证
Lihua Wang,Wenjing Zhao,Zhongfeng Cui et al.
Lihua Wang et al.
Introduction: Intrahepatic cholangiocarcinoma (iCCA) is characterized by heterogeneity and poor survival. It remains unclear how telomere maintenance programs influence the prognosis and immune microenvironment in iCCA, a...
Marc Henein,Yannis Trakadis
Marc Henein
The rapid expansion of genetic therapies for the treatment of monogenic disorders represents one of the most transformative developments in contemporary medicine. Given the novelty, significant risks, and high costs of these treatments, the...