Current Status in the Discovery of Covalent Janus Kinase 3 (JAK3) Inhibitors [0.03%]
共价Janus激酶3(JAK3)抑制剂的发现现状
Jun Dai,LiXi Yang,Glynn Addison
Jun Dai
The search for inhibitors of the Janus kinase family (JAK1, JAK2, JAK3 and TYK2) has been ongoing for several decades and has resulted in a number of JAK inhibitors being approved for use in patients, such as tofacitinib for the treatment o...
Natural Tyrosinase Inhibitors: Role of Herbals in the Treatment of Hyperpigmentary Disorders [0.03%]
天然酪氨酸酶抑制剂：草药在色素沉着障碍治疗中的作用
Kamal Uddin Zaidi,Sharique A Ali,Ayesha Ali et al.
Kamal Uddin Zaidi et al.
Cutaneous pigmentation plays critical role in determining the color of skin along with photo protection of skin from dreadful effects of ultraviolet radiations. Conversely, abnormal accumulation of melanin is responsible for hyper pigmentar...
Latent Tuberculosis Infection (LTBI) and Its Potential Targets: An Investigation into Dormant Phase Pathogens [0.03%]
潜伏性结核感染（LTBI）及其潜在靶点：休眠期病原体的研究
Gopichand Gutti,Karan Arya,Sushil Kumar Singh
Gopichand Gutti
One-third of the world's population harbours the latent tuberculosis infection (LTBI) with a lifetime risk of reactivation. Although, the treatment of LTBI relies significantly on the first-line therapy, identification of novel drug targets...
Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System [0.03%]
酚类化合物和富含酚类的精油对心血管系统的保护作用
Jorge M Alves-Silva,Mónica Zuzarte,Carla Marques et al.
Jorge M Alves-Silva et al.
Background: Cardiovascular diseases are the leading cause of global mortality with a tendency to increase due to population ageing as well as an increase in associated risk factors. Although current therapies improve surv...
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia [0.03%]
内源性萜类化合物作为LPS诱导的BV-2小胶质细胞神经炎症抑制剂的作用研究
Yuanzhen Xu,Hongbo Wei,Jinming Gao
Yuanzhen Xu
Neuroinflammation is a typical feature of many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Microglia, the resident immune cells of the brain, readily become activated in response to an infection or an ...
Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents [0.03%]
抗菌剂氮杂喹唑啉和取代苯并噻嗪的合成
Asmaa F Kassem,Fatimah Alshehrei,Eman M H Abbas et al.
Asmaa F Kassem et al.
Background & objective: Quinazolines and their fused systems are noteworthy in pharmaceutical chemistry due to their wide range of biological activities. ...
Marialuigia Fantacuzzi,Barbara De Filippis,Rosa Amoroso et al.
Marialuigia Fantacuzzi et al.
Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors which belong to the ligand-activated nuclear receptor superfamily. They are ubiquitously expressed throughout the body. So far, three major subtypes have been i...
Spinacia oleracea Linn Considered as One of the Most Perfect Foods: A Pharmacological and Phytochemical Review [0.03%]
羽衣甘蓝（Spinacia oleracea Linn）被认为是完美的食物之一：药理和植物化学综述
Rosa Martha Perez Gutierrez,Elisa Gutierrez Velazquez,Silvia Patricia Paredes Carrera
Rosa Martha Perez Gutierrez
Background: Leaves of Spinacia oleracea have been widely used as vegetarian foods. Some studies on the chemical composition of spinach have shown that it contains a high content of micronutrients (vitamins and minerals), ...
Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review [0.03%]
硫唑烷二酮衍生物的化学合成、作用机制及其抗癌潜力：综述性研究论文
Harsh Kumar,Aakash Deep,Rakesh Kumar Marwaha
Harsh Kumar
Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical class of compounds for the development of new drugs. So, many scholars have synthesized these derivatives as target molecules and evaluated their bi...
Bisphosphonates and Cancer: A Relationship Beyond the Antiresorptive Effects [0.03%]
双膦酸盐与癌症：超出抗吸收作用的关系
Sonia Teixeira,Luis Branco,Maria H Fernandes et al.
Sonia Teixeira et al.
Bisphosphonates (BPs) are stable analogues of the Inorganic Pyrophosphate (PPi), an endogenous regulator of bone mineralization, which can resist the hydrolysis in the gastrointestinal tract. Their conformation allows targeting the bone as ...