Identification of Inhibitors against Botulinum Neurotoxins: 8-Hydroxyquinolines Hold Promise [0.03%]
肉毒神经毒素抑制剂的鉴定：8-羟基喹啉大有潜力
Ritika Chauhan,Vinita Chauhan,Priyanka Sonkar et al.
Ritika Chauhan et al.
Botulinum neurotoxins (BoNTs) are the most toxic category A biological warfare agents. There is no therapeutics available for BoNT intoxication yet, necessitating the development of a medical countermeasure against these neurotoxins. The di...
Miao Li,Meng Pan,Chengzhong You et al.
Miao Li et al.
MiRNAs play an important role in cancers. As a potent tumor suppressor, miRNA-7(miR-7) has been demonstrated to inhibit the diverse fundamental biological processes in multiple cancer types including initiation, growth and metastasis by tar...
Three-dimensional Quantitative Structure-activity Relationship (3DQSAR) and Molecular Docking Study of 2-((pyridin-3-yloxy)methyl) Piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders [0.03%]
2-((吡啶-3-基氧基)甲基)哌嗪类α7尼古丁乙酰胆碱受体调节剂治疗炎症性疾病的三维定量结构活性关系（3DQSAR）和分子对接研究
Deepika Purohit,Vandana Saini,Sanjiv Kumar et al.
Deepika Purohit et al.
Background & objective: Comparative molecular field analysis (CoMFA) of 27 analogues of 2-((pyridin-3-yloxy)methyl)piperazine derivatives was carried out using software Tripos SYBYL X. Optimal r2 (0.854) and q2 (0.541) va...
Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus [0.03%]
光刺激介导的偶氮苯接枝介孔硅纳米粒子载药系统研究新进展
Sandra Ramírez-Rave,María Josefa Bernad-Bernad,Jesús Gracia-Mora et al.
Sandra Ramírez-Rave et al.
Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompati...
Rhodiola and salidroside in the treatment of metabolic disorders [0.03%]
Rhodiola和salidroside在代谢障碍治疗中的作用
Xiang-Li Bai,Xiu-Ling Deng,Guang-Jie Wu et al.
Xiang-Li Bai et al.
Over the past three decades, the knowledge gained about the mechanisms that underpin the potential use of Rhodiola in stress- and ageing-associated disorders has increased, and provided a universal framework for studies that focused on the ...
Soluble Guanylate Cyclase Stimulators and Activators: Where are We and Where to Go? [0.03%]
可溶性鸟苷酸环化酶刺激剂和激活剂：现状如何？未来何去何从？
Sijia Xiao,Qianbin Li,Liqing Hu et al.
Sijia Xiao et al.
Soluble Guanylate Cyclase (sGC) is the intracellular receptor of Nitric Oxide (NO). The activation of sGC results in the conversion of Guanosine Triphosphate (GTP) to the secondary messenger cyclic Guanosine Monophosphate (cGMP). cGMP modul...
Nandini Pathak,Ekta Rathi,Nitesh Kumar et al.
Nandini Pathak et al.
Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which imparts a broad spectrum of biological activities to it. The significant and potent activity of benzothiazole moiety influenced distinctively by nature and...
Recent Advances in the HPLC Analysis of Tricyclic Antidepressants in Bio-Samples [0.03%]
生物样品中三环类抗抑郁药HPLC分析最新进展
Natalia Manousi,Victoria F Samanidou
Natalia Manousi
Tricyclic Antidepressants (TCAs) are a group of the main category of antidepressant drugs, which are commonly prescribed to treat major depressive disorder. Determination of TCA drugs is very important for clinical and forensic toxicology, ...
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation [0.03%]
黄酮醇/黄酮在神经退行性疾病和神经炎症中的作用
Zehra Calis,Rasim Mogulkoc,Abdülkerim Kasim Baltaci
Zehra Calis
The inflammatory process in the human body is a physiological response involving many cellular types and mediators. It results in scar formation to separate the damaged area from the surrounding healthy tissue. Because of increased blood-br...