Deepika Sharma,Gopal Singh Bisht
Deepika Sharma
The current trend of increment in the frequency of antifungal resistance has brought research into an era where new antifungal compounds with novel mechanisms of action are required. Natural antimicrobial peptides, which are ubiquitous comp...
Coumarin-based Scaffold as α-glucosidase Inhibitory Activity: Implication for the Development of Potent Antidiabetic Agents [0.03%]
基于香豆素的支架作为α-葡萄糖苷酶抑制剂活性：开发高效的抗糖尿病药物的意义
Tadesse Bekele Tafesse,Mohammed Hussen Bule,Mehdi Khoobi et al.
Tadesse Bekele Tafesse et al.
Background: Delaying the absorption of glucose through α-glucosidase enzyme inhibition is one of the therapeutic approaches in the management of Type 2 diabetes, which can reduce the incidence of postprandial hyperglycem...
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages [0.03%]
通过酰胺或酯-酰胺键连接脂肪族或芳烃核心的新型双-1,4-二氢吡啶类化合物的合成、细胞毒性和分子对接模拟研究
Amna M Abdella,Amr M Abdelmoniem,Nada S Ibrahim et al.
Amna M Abdella et al.
Objective: Novel bis(1,4-dihydropyridine-3,5-dicarbonitrile) derivatives linked to aliphatic or aromatic cores via amide or ester-amide linkages were prepared and their structures were confirmed by several spectral tools....
First Synthesis for Bis-Spirothiazolidine Derivatives as a Novel Heterocyclic Framework and Their Biological Activity [0.03%]
首个双螺环噻唑啶衍生物的异类合成及其生物活性研究
Eman M Flefel,Walaa I El-Sofany,Hanem M Awad et al.
Eman M Flefel et al.
Background: Spirothiazolidines are versatile synthetic scaffold possessing wide spectrum of biological interests involving potential anticancer activity. ...
Withdrawal Notice: Dietary Fatty Acids-effects on Cardiovascular Disease [0.03%]
撤回通知：膳食脂肪酸-对心血管疾病的影响
Jasmin Kharazmi Khorassani,Sara Kharazmi Khorassani,Asma Afshari et al.
Jasmin Kharazmi Khorassani et al.
The article has been withdrawn at the request of editor of the journal Mini-Reviews in Medicinal Chemistry: Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. ...
Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents [0.03%]
高选择性乙酰胆碱酯酶抑制剂的设计合成及活性研究
Yaghoub Pourshojaei,Khalil Eskandari,Ali Asadipour
Yaghoub Pourshojaei
Alzheimer, a progressive disease, is a common term for memory loss which interferes with daily life through severe influence on cognitive abilities. Based on the cholinergic hypothesis, and Xray crystallographic determination of the structu...
Yue Zhao,Bocheng Yan,Zhaoyu Wang et al.
Yue Zhao et al.
Natural polysaccharide is a kind of natural macromolecular which can be extracted from plants, fungi, algae, animals, and bacteria. The monosaccharide compositions and glucosidic bonds of polysaccharides from different origins vary substant...
Hao Jin,Min Cui
Hao Jin
Objective: This mini-review aims to discuss research works about heparanase published in 2016, 2017, 2018 and 2019 and provide a direction for therapy methods targeting heparanase. ...
Syeda Khair-Ul-Bariyah,Muhammad Arshad,Muhammad Ali et al.
Syeda Khair-Ul-Bariyah et al.
Benzocaine is well-known for its role as an anesthetic agent and largely used in oral ulcers, ear pain and dental complications. Along with lidocaine and other local anesthetics, benzocaine has marked it as an anesthetic agent in surgical p...
Hyaluronan Fragmentation During Inflammatory Pathologies: A Signal that Empowers Tissue Damage [0.03%]
炎症病理过程中透明质酸的降解：一种促进组织损伤的信号分子
Angela Avenoso,Giuseppe Bruschetta,Angela D Ascola et al.
Angela Avenoso et al.
The mechanisms that modulate the response to tissue injury are not fully understood. Abnormalities in the repair response are associated with a variety of chronic disease states characterized by inflammation, followed subsequently by excess...