Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus [0.03%]
巴雷特食管的治疗：质子泵抑制剂与射频消融法
Predrag Dugalic,Srdjan Djuranovic,Aleksandra Pavlovic-Markovic et al.
Predrag Dugalic et al.
Gastroesophageal Reflux Disease (GERD) is characterized by acid and bile reflux in the distal oesophagus, and this may cause the development of reflux esophagitis and Barrett's oesophagus (BE). The natural histological course of untreated B...
Synthesis and Biological Activity of Embelin and its Derivatives: An Overview [0.03%]
埃姆BIN和它的衍生物的合成及生物活性研究综述
Zhaojun Sheng,Siyuan Ge,Min Gao et al.
Zhaojun Sheng et al.
Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family, and contains two carbonyl groups, a methine group and two hydroxyl groups. With embelin as the lead compound, more than one...
Tamás Biernacki,Dániel Sandi,Krisztina Bencsik et al.
Tamás Biernacki et al.
Background: In the recent years, many novel Disease-Modifying Drugs (DMD) have been introduced to the market in the treatment of multiple sclerosis. Objec...
Zhi-Gang Sun,Yang-Liu,Jin-Mai Zhang et al.
Zhi-Gang Sun et al.
Blood coagulation is the process of changing the blood from the flowing state to the gel state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated...
Mengxun Shi,Tao Cheng,Huibin Zou et al.
Mengxun Shi et al.
Biopolyesters represent a large family that can be obtained by polymerization of variable bio-derived hydroxyalkanoic acids. The monomer composition, molecular weight of the biopolyesters can affect the properties and applications of the po...
Design, Synthesis, Molecular Docking Study and Anti-Hepatocellular Carcinoma Evaluation of New Bis-Triazolothiadiazines [0.03%]
新型双三氮唑噻二嗪的设计、合成、分子对接研究及抗肝癌评价
Sobhi M Gomha,Zeinab A Muhammad,Elham Ezz El-Arab et al.
Sobhi M Gomha et al.
Objective: The reaction of bis(4-amino-4H-1,2,4-triazole-3-thiol) with hydrazonoyl halides and α-halo-ketones gave a new series of bis-1,2,4-triazolo[3,4-b]thiadiazine derivatives. ...
Targeting Integrase Enzyme: A Therapeutic Approach to Combat HIV Resistance [0.03%]
瞄准整合酶：对抗艾滋病耐药性的治疗策略
Daipule Komal,Joshi Khushboo,Sethi Aaftaab et al.
Daipule Komal et al.
Global Human Immunodeficiency Virus (HIV) statistics by the World Health Organization (WHO) for the year 2017 was estimated to be 36.9 (31.1-43.9) million. Antiviral drug resistance poses a serious threat to public health and requires immed...
Synthesis and Biological Activity of Hydrazones and Derivatives: A Review [0.03%]
腙及其衍生物的合成及生物活性研究进展综述
Juliana de Oliveira Carneiro Brum,Tanos Celmar Costa França,Steven R LaPlante et al.
Juliana de Oliveira Carneiro Brum et al.
Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer's, cancer, inflammation, and leishmaniasis. However, most o...
Quercetin-Amino Acid Conjugates are Promising Anti-Cancer Agents in Drug Discovery Projects [0.03%]
檞皮素-氨基酸衍生物在药物发现中的抗肿瘤活性研究项目
Alexey V Dobrydnev,Tetiana M Tkachuk,Viktor P Atamaniuk et al.
Alexey V Dobrydnev et al.
Quercetin is a plant flavonoid with great potential for the prevention and treatment of disease. Despite the curative application of quercetin is hampered by low bioavailability, its core serves as a scaffold for generating more potent comp...
Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles [0.03%]
金丝桃属研究进展：生物活性及代谢轮廓更新
Mariangela Marrelli,Giancarlo Statti,Filomena Conforti
Mariangela Marrelli
Plants from the genus Hypericum, one genus of the Hypericaceae family, have attracted a lot of attention for their potential pharmaceutical applications. Most of the studies in the literature focus on H. perforatum L. (common St. John's wor...