Rajiv K Tonk,Sandhya Bawa,Deepak Kumar
Rajiv K Tonk
Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity throu...
A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies [0.03%]
一系列新的腙衍生物的合成、分子对接及抗乙酰胆碱酯酶活性研究
İrem Bozbey,Zeynep Özdemir,Harun Uslu et al.
İrem Bozbey et al.
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulati...
Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action [0.03%]
噻二唑卡巴肼的抗肿瘤作用及其作用机制研究
Bhushan Shakya,Paras Nath Yadav
Bhushan Shakya
Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the focus of chemists and biologists due to their wide range of pharmacologic...
Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia [0.03%]
Oroxylin A及其衍生物治疗急性髓系白血病的研究进展
Xu Hu,Yan Wang,Xiang Gao et al.
Xu Hu et al.
First stage human clinical trial (CTR20150246) for HAO472, the L-alanine-(14-oridonin) ester trifluoroacetate, was conducted by a Chinese company, Hengrui Medicine Co. Ltd, to develop a new treatment for acute myelogenous leukemia. Two pate...
Phytochemicals and Potential Therapeutic Targets on Toxoplasma gondii Parasite [0.03%]
植物化学成分及潜在的治疗靶点对弓形虫寄生虫的作用
Sharif Alhassan Abdullahi,Ngah Zasmy Unyah,Noshariza Nordin et al.
Sharif Alhassan Abdullahi et al.
Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agen...
An Insight into the Synthesis and SAR of 2,4-Thiazolidinediones (2,4-TZD) as Multifunctional Scaffold: A Review [0.03%]
2,4-噻唑烷二酮（TZDs）作为多功能药效骨架的合成及构效关系研究综述
Navjot Singh Sethi,Deo Nandan Prasad,Rajesh Kumar Singh
Navjot Singh Sethi
2,4-Thiazolidinedione (2,4-TZD) is a versatile pharmacophore, a privileged scaffold, and a remarkable sulphur-containing heterocyclic compound with diverse pharmacological activities. The multifarious biological activities, due to different...
Miroslav Pohanka
Miroslav Pohanka
Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents....
Dervis Dasdelen,Rasim Mogulkoc,Abdülkerim Kasim Baltaci
Dervis Dasdelen
In the literature screening, aquaporins were found in the cerebral structures including the pia mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and suprachiasmatic nuclei, white matter and subcorti...
Yutao Xie,Yunlong Wang,Wei Xiang et al.
Yutao Xie et al.
Natural compounds, such as paclitaxel and camptothecin, have great effects on the treatment of tumors. Such natural chemicals often achieve anti-tumor effects through a variety of mechanisms. Therefore, it is of great significance to conduc...
Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress [0.03%]
牡丹酚衍生物及其药理活性的研究进展
Jilei Wang,Guiying Wu,Haiping Chu et al.
Jilei Wang et al.
Paeonol, 2-hydroxy-4-methoxy acetophenone, is one of the main active ingredients of traditional Chinese medicine such as Cynanchum paniculatum, Paeonia suffruticosa Andr and Paeonia lactiflora Pall. Modern medical research has shown that pa...