Will Arsenic Trioxide Benefit Treatment of Solid Tumor by Nano- Encapsulation? [0.03%]
纳米包裹能否增强砷剂对实体瘤的治疗效果？
Xin Fu,Yan-Shu Li,Jun Zhao et al.
Xin Fu et al.
Arsenic trioxide (ATO) has remarkably enhanced therapeutic efficacy in treating both newly diagnosed and relapsed patients suffering from Acute Promyelocytic Leukemia (APL). Unfortunately, whether as a single agent, component of combined ch...
Mahesh S Vasava,Manoj N Bhoi,Sanjay K Rathwa et al.
Mahesh S Vasava et al.
In the last 2-3 decades, the broad research in the application of benzimidazole derivatives made it important for mankind. Many scientists have worked on benzimidazole derivatives and they found that this compound has a diverse role in the ...
Annalise R Pfaff,Justin Beltz,Emily King et al.
Annalise R Pfaff et al.
The thiol (-SH) functional group is found in a number of drug compounds and confers a unique combination of useful properties. Thiol-containing drugs can reduce radicals and other toxic electrophiles, restore cellular thiol pools, and form ...
Carbonaceous Nanomaterials-Mediated Defense Against Oxidative Stress [0.03%]
基于石墨相氮化碳的类酶氧化应激响应型光动力/声动力协同治疗肿瘤
Natalia Forbot,Paulina Bolibok,Marek Wiśniewski et al.
Natalia Forbot et al.
The concept of nanoscale materials and their applications in industrial technologies, consumer goods, as well as in novel medical therapies has rapidly escalated in the last several years. Consequently, there is a critical need to understan...
1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects [0.03%]
1,4-二氢吡啶类：一种具有可靠异环结构和潜在预期疗效的化合物
Abhinav Prasoon Mishra,Ankit Bajpai,Awani Kumar Rai
Abhinav Prasoon Mishra
Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent th...
Triple Negative Breast Cancer: How Neurokinin-1 Receptor Antagonists Could Be Used as a New Therapeutic Approach [0.03%]
三阴性乳腺癌：神经激肽-1受体拮抗剂如何可作为新的治疗途径
Miguel Muñoz,Marisa Rosso,Rafael Coveñas
Miguel Muñoz
Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer death among females. BC cells not showing HER-2/Neu amplification and not expressing estrogen/ progesterone receptors are named triple-negative BC (T...
Macromolecular Prodrugs Containing Organoiron-Based Compounds in Cancer Research: A Review [0.03%]
含有机铁化合物的高分子前药在癌症研究中的应用：综述
Elie Hembe Mukaya,Xavier Yangkou Mbianda
Elie Hembe Mukaya
Among the methods used for the treatment of cancer, chemotherapy is widely used, and it is by far one of the most unpleasant procedures given to a patient because of its severe side effects; while being necessary. One of the major problems ...
Advances on the Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships of Cytisine Derivatives [0.03%]
苦马豆素衍生物的生物活性、全合成、结构修饰及构效关系研究进展
Xiaobo Huang,Hui Xu
Xiaobo Huang
Cytisine is a quinolizidine alkaloid isolated from various Leguminosae plants. Cytisine and its derivatives exhibit a broad range of biological properties, such as smoking cessation aid, antidepressant, neuroprotective, nootropic, anticance...
Bianca L B Marino,Lucilene R de Souza,Kessia P A Sousa et al.
Bianca L B Marino et al.
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the elderly population, with a higher prevalence in men, independent of race and social class; it affects approximately 1.5 to 2.0% of the elderly population ov...
Pharmacokinetics-based Dose Management of 5-Fluorouracil Clinical Research in Advanced Colorectal Cancer Treatment [0.03%]
基于药代动力学的氟尿嘧啶临床研究剂量管理在晚期结直肠癌治疗中的应用
Rong Deng,Lin Shi,Wei Zhu et al.
Rong Deng et al.
Objective: The study aimed to explore the efficacy of pharmacokinetic-based 5-fluorouracil dose management by plasma concentration test in advanced colorectal cancer treatment. ...