Transforming Non-Selective Angiotensin-Converting Enzyme Inhibitors in C- and N-domain Selective Inhibitors by Using Computational Tools [0.03%]
使用计算工具将非选择性的血管紧张素转换酶抑制剂转化为C域和N域选择性抑制剂
Sergio Alfaro,Carlos Navarro-Retamal,Julio Caballero
Sergio Alfaro
The two-domain dipeptidylcarboxypeptidase Angiotensin-I-converting enzyme (EC 3.4.15.1; ACE) plays an important physiological role in blood pressure regulation via the reninangiotensin and kallikrein-kinin systems by converting angiotensin ...
Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry [0.03%]
乙酰胆碱酯酶抑制剂的计算研究：从中毒理到化学
Kiran Bagri,Ashwani Kumar,Manisha et al.
Kiran Bagri et al.
Acetylcholinesterase inhibitors are the most promising therapeutics for Alzheimer's disease treatment as these prevent the loss of acetylcholine and slows the progression of the disease. The drugs approved for the management of Alzheimer's ...
Hamidreza Ardalani,Amin Hadipanah,Amirhossein Sahebkar
Hamidreza Ardalani
Peptic Ulcer Disease (PUD) is the most common disorder of the stomach and duodenum, which is associated with Helicobacter pylori infection. PUD occurs due to an imbalance between offensive and defensive factors and Proton Pump Inhibitors (P...
Synthesis, Antimicrobial and Antitumor Evaluations of a New Class of Thiazoles Substituted on the Chromene Scaffold [0.03%]
基于色满骨架取代的新类噻唑的合成及其抗微生物和抗肿瘤评价研究
Dina H Elnaggar,Naglaa A Abdel Hafez,Huda R M Rashdan et al.
Dina H Elnaggar et al.
Background & objective: A new series of thiazoles substituted on the chromene scaffold were prepared by facial approaches starting from (E)-1-(2,3-Dihydrochromen-4-ylidene)thiosemicarbazide derivatives (2a,b). The thiosem...
Design of Metal-Organic Frameworks for pH-Responsive Drug Delivery Application [0.03%]
用于pH响应型药物输送的金属有机框架材料的设计
Xin Shen,Ying Pan,Zhihao Sun et al.
Xin Shen et al.
Metal-Organic Frameworks (MOFs) have aroused great interest in the field of nanoscience and nanotechnology particularly in biomedical domains, such as Drug Delivery System (DDS), Biomedical Imaging (BI) and Photodynamic Therapy (PDT). As an...
Influence of Plant Bioactive Compounds on Intestinal Epithelial Barrier in Poultry [0.03%]
植物生物活性物质对家禽肠上皮屏障的影响
Amlan Kumar Patra
Amlan Kumar Patra
Natural plant bioactive compounds (PBC) have recently been explored as feed additives to improve productivity, health and welfare of poultry following ban or restriction of in-feed antibiotic use. Depending upon the types of PBC, they posse...
Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents [0.03%]
近年来大环内酯抗生素作为抗菌剂的研究进展
Yinhui Qin,Shutao Ma
Yinhui Qin
The chemical modification of natural products has been a major method in the discovery and synthesis of new macrolide antibiotics (MA) to treat a variety of infectious diseases. However, a lot of MA obtained in the above methods are no long...
Alejandro Speck-Planche
Alejandro Speck-Planche
This work discusses the idea that drug discovery, instead of being performed through a series of filtering-based stages, should be viewed as a multi-scale optimization problem. Here, the most promising multi-scale models are analyzed in ter...
Aurelio Ortiz,Estibaliz Sansinenea
Aurelio Ortiz
The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of serious public health problem all over the world. In this sense, natural products have been a rich source of compo...
Jyotsna Bhatt Mitra,Veerendra K Sharma,Mukesh Kumar et al.
Jyotsna Bhatt Mitra et al.
The ubiquitous occurrence of Antimicrobial Peptides (AMPs) in all domains of life emphasizes their crucial role as ancient mediators of host defense. Despite their antiquity and prolonged history of exposure to pathogens, endogenous AMPs co...