Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents [0.03%]
苯并噻嗪和三唑的单分子实体组装：-氧卡姆衍生的新型分子的合成及其作为潜在抗菌/抗肿瘤剂的研究
Papigani Neeraja,Suryapeta Srinivas,Venkanna Banothu et al.
Papigani Neeraja et al.
Background: Benzothiazine derivatives, because of their various biological activities have attracted particular attention in Med Chem and drug discovery efforts. The synthetic modifications of 1,2-benzothiazine 1,1-dioxid...
Srijit Das,Isa Naina Mohamed,Seong Lin Teoh et al.
Srijit Das et al.
The incidence of Metabolic Syndrome (MetS) has risen globally. MetS includes a combination of features, i.e. blood glucose impairment, excess abdominal/body fat dyslipidemia and elevated blood pressure. Other than conventional treatment wit...
Anahita Boveiri Dehsheikh,Mohammad Mahmoodi Sourestani,Paria Boveiri Dehsheikh et al.
Anahita Boveiri Dehsheikh et al.
Medicinal plants have a wide range of secondary metabolites including monoterpene. These volatile compounds are the main components of essential oils, belonging to the isoprenoid group and possessing valuable features for plants and humans....
Campylobacter: A Review of New Promising Remedies with Medicinal Plants and Natural Antioxidants [0.03%]
乳酸菌：一种新的有希望的药物与药用植物和天然抗氧化剂综述
Iraj Salimikia,Mahmoud Bahmani,Saber Abbaszadeh et al.
Iraj Salimikia et al.
Campylobacter (curved bacteria) is considered one of the most important and common zoonotic bacteria and the three leading bacterial causes of gastroenteritis and diarrhea. Antibacterial resistance is growing and expanding. The aim of this ...
Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment [0.03%]
以丝裂原活化蛋白激酶为靶点的咔唑类抗肿瘤药物的设计、合成及生物活性研究
Jessica Ceramella,Domenico Iacopetta,Alexia Barbarossa et al.
Jessica Ceramella et al.
Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human...
Faisal Jamshaid,Jun Dai,Li Xi Yang
Faisal Jamshaid
Many berberine derivatives have been synthesized for their antibacterial activity in the past years. In order to elucidate their new Structural Activity Relationship (SAR), the recently synthesized berberine derivatives are reviewed. The ne...
Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance [0.03%]
范可尼贫血性DNA修复途径作为克服癌症药物耐药性的新机制
Kajal Ghosal,Christian Agatemor,Richard I Han et al.
Kajal Ghosal et al.
Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance ari...
Hui Li,Erna Jia,Yu Hong et al.
Hui Li et al.
Nonalcoholic Fatty Liver Disease (NAFLD) includes a variety of changes including nonalcoholic fatty liver, cirrhosis and Hepatocellular Carcinoma (HCC), which are associated with metabolic disorders and cardiovascular diseases. The pathogen...
Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives [0.03%]
醛，胺和草酰乙酸类似物的多组分反应生成生物吸引性的吡咯衍生物
Stella Manta,Nikolaos Kollatos,Christos Mitsos et al.
Stella Manta et al.
Pyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse rou...
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer's Disease [0.03%]
potent acetylcholinesterase inhibitors: potential drugs for alzheimer's disease
Hulya Akıncıoğlu,İlhami Gülçin
Hulya Akıncıoğlu
Alzheimer's disease (AD) is one of the cognitive or memory-related impairments occurring with advancing age. Since its exact mechanism is not known, the full therapy has still not been found. Acetylcholinesterase (AChE) has been reported to...