Ahmed Amleh,M İhsan Han
Ahmed Amleh
Sulfonamide-based compounds have garnered significant interest in antidiabetic drug research due to their flexible structures and diverse range of biological effects. This review compiles studies on sulfonamide derivatives evaluated against...
Iridoids as Multi-Target Neuroprotective Agents for Ischemic Stroke: Mechanisms and Therapeutic Potential [0.03%]
异域烷类化合物作为缺血性脑卒中多靶点神经保护剂的机制和治疗潜力研究
Haiyi Gao,Mingtao Wang,Xinyue Zheng et al.
Haiyi Gao et al.
Ischemic stroke continues to be a predominant global cause of death and long-term disability, with therapeutic options remaining notably constrained. Against this challenging backdrop, iridoids-natural monoterpenoids abundantly present in v...
Exploration of Schiff Bases: Structures, Syntheses, and Biological Activities [0.03%]
Schiff碱的研究：结构、合成及生物活性
Badr Sellami,Imane Yamari,Samir Chtita
Badr Sellami
Schiff bases are organic compounds that were first discovered in 1864 by German chemist Hugo Schiff. These bases result from a condensation reaction between a primary amine and a carbonyl compound, usually an aldehyde or a ketone. This reac...
Emerging Roles of Small-molecule Derivatives in Modulating Neurodegenerative Pathways: From Molecular Targets to Therapeutic Applications [0.03%]
小分子衍生物在调节神经退行性疾病通路中的新作用：从分子靶点到治疗应用
Kuldeep Singh,Pranshul Sethi,Divya Jain et al.
Kuldeep Singh et al.
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease involve progressive neuronal dysfunction driven by mechanisms including protein aggregation, oxidative str...
Minoxidil as a Prodrug: Review of Chemical, Pharmacological, and Technological Aspects in Alopecia Therapeutics [0.03%]
米诺地尔作为前药：脱发治疗中的化学、药理和制剂方面的综述
Gustavo Terra de Oliveira,Ana Beatriz Kimie Baiocco Ikegaki,Isadora Luziana Izidoro de Souza et al.
Gustavo Terra de Oliveira et al.
Alopecia is a prevalent condition that affects both sexes, characterised by miniaturisation of hair follicles and changes in the dynamics of the hair cycle, such as androgenetic alopecia associated with various systemic factors, including t...
Quinone Derivatives as Nrf2 Activators: Antioxidant Effects, Therapeutic Potential, and Toxicity [0.03%]
醌衍生物作为Nrf2激活剂：抗氧化作用、治疗潜力和毒性
Melford Chuka Egbujor,David Chinemerem Nwobodo,Oluebube Ezenwafor
Melford Chuka Egbujor
Quinone derivatives are redox-modulating scaffolds with notable antioxidant properties. Quinones are naturally occurring and synthetic conjugated cyclic diketones. Owing to their structural and chemical diversity, quinones possess diverse b...
Development of Triazole based Anticonvulsants through Various Catalytic Approaches [0.03%]
基于三唑的抗惊厥药物的开发各种催化方法
Shobha Rani,Shiva Teotia,Sumitra Nain
Shobha Rani
Triazole-containing compounds will result in the production of various pharmacologically effective drugs. Epilepsy is a severe neurological disorder primarily managed by controlling seizures using antiepileptic drugs, which are often relate...
Diamonds for the Mind: Exploring the Potential of Adamantane against Alzheimer's Disease [0.03%]
钻石般的智慧：探索金刚烷在对抗阿尔茨海默病方面的潜力
Preeya Negi,Nitin Dnyaneshwar Arote,Vandana Bharat Patravale
Preeya Negi
Alzheimer's disease (AD) is the predominant type of dementia, emerging as a major health issue globally due to its increasing incidence and the limited approved therapies that provide only symptomatic relief. Adamantane, a diamondoid hydroc...
Retrospection of Argemone mexicana and its Derived Analogs as a Futuristic Approach Exhibiting Anticancer Potential [0.03%]
墨西哥千里光及其衍生物作为未来抗癌研究的前景展望的回顾性分析
Sunanda Kulshrestha,Istuti Saraswat,Anjana Goel
Sunanda Kulshrestha
Argemone mexicana (Linn.), commonly known as prickly poppy, is a well-documented medicinal plant in Indian Ayurvedic literature, recognized for its diverse pharmacological properties. It has been investigated for its potential applications ...
Research Progress on Pyrazine-based Medicinally Active Compounds: A Review [0.03%]
基于吡嗪类药物活性化合物的研究进展综述
Karan Joshi,Omkumar Prajapati,Sadaf Mirza et al.
Karan Joshi et al.
Medicinal chemists are highly interested in pyrazine-based compounds due to their diverse biological roles and potential therapeutic applications for various disorders. This research examines the expansion of pyrazine-derived compounds betw...