Structural and Electronic Determinants Underlying the Biofunctional Profile of Isothiocyanates: A Structure-activity Insight [0.03%]
异硫氰酸盐生物功能谱的结构和电子决定因素：结构活性关系研究
Penlisola Longkumer,Basanta Singha,Partha Pratim Gogoi et al.
Penlisola Longkumer et al.
Isothiocyanates (ITCs), naturally derived from glucosinolates in cruciferous vegetables, represent a versatile class of electrophilic compounds with diverse biological activities. Their characteristic -N=C=S moiety mediates covalent interac...
Hybrid Pharmacophores in Cancer Treatment: Emphasis on Coumarinbased Scaffolds and Their Multi-target Mechanisms [0.03%]
抗癌治疗中的杂化药效团：肉桂烷系支架及其多靶向机制的综述
Sanheeta Chakrabarty,Rimmi Lata,Sanju Kumari et al.
Sanheeta Chakrabarty et al.
Hybrid molecules have emerged as a promising strategy in anti-cancer drug discovery, offering the ability to simultaneously modulate multiple molecular targets and overcome limitations associated with conventional chemotherapeutics. This re...
Antimicrobial Efficacy and Mechanistic Insights of 0D, 1D, 2D, and 3D Nanoparticles: A Review [0.03%]
零维、一维、二维和三维纳米颗粒的抗菌功效及机制见解综述
Shruthi Venkataraman,Raji Atchudan,Sandeep Arya et al.
Shruthi Venkataraman et al.
The escalating global challenge of Antimicrobial Resistance (AMR) underscores the urgent need for alternative therapeutic approaches beyond conventional antibiotics. Nanoparticles (NP), with their distinct physicochemical properties, tunabl...
Fahad Saeed Algahtani,Mohammed Abdullah Alzubaidi,Abdullah M Al Shumrani et al.
Fahad Saeed Algahtani et al.
Oral cancer, primarily oral squamous cell carcinoma (OSCC), remains a significant global health challenge due to its high morbidity, frequent late-stage diagnosis, and limited therapeutic options. Metal-based chemotherapeutics have emerged ...
Extraction and Mass Spectrometry Detection of Cannabinoids in Clinical Samples [0.03%]
临床样本中大麻素的提取与质谱检测技术
Matthew Coughlin,Mahdi Garelnabi
Matthew Coughlin
The legalization of cannabis products across many states in the USA has sparked a surge of interest within the scientific and medical communities, prompting researchers to investigate the pharmacological and mechanistic properties of the nu...
The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies [0.03%]
皮肤细胞外微环境的三重调控框架及相关抗衰老策略
Liangsen Zhao,Yong Liao
Liangsen Zhao
This review proposes a tripartite regulatory framework for the Skin Extracellular Microenvironment (SEM), which the authors conceptualize as three cross-talked functional domains: hydration, nutritional, and signaling microenvironments. It ...
Polymer-doxorubicin Conjugates: Redefining Chemotherapy for Breast Cancer [0.03%]
聚多柔比星共轭物：重新定义乳腺癌化疗
Sneha Kumari,Aman Kumar,Md Mustahidul Islam et al.
Sneha Kumari et al.
Polymer drug conjugates (PDCs) represent a targeted modification of conventional chemotherapeutics, transforming small-molecule drugs like doxorubicin (dox) into macromolecular structures with significantly altered biological properties. By...
The Multifaceted Potential of Adhatoda vasica Nees: Traditional Uses, Pharmacological Activities and Biotechnological Applications [0.03%]
腺毛蕊花(Nees)的多面潜力：传统用途、药理活性及生物技术应用
Sekhar Tiwari,Priyanka Panchal,Harsh Mehta et al.
Sekhar Tiwari et al.
Adhatoda vasica Nees (A. vasica), known as the Malabar nut, belongs to the Acanthaceae family and is widely distributed across South and Southeast Asia. It is used in Ayurveda and Unani medicine as a therapy for human diseases, such as resp...
Beyond a Psychotropic Plant: Exploring the Ethnomedicinal Value of Anadenanthera colubrina var. cebil [0.03%]
超越一种精神活性植物——探究Anadenanthera colubrina var. cebil的民族医药价值
Romina Belen González,Gonzalo Adrián Ojeda,Ana Melissa González Miragliotta et al.
Romina Belen González et al.
Anadenanthera colubrina var. cebil (Griseb.) is an ecologically adaptable species native to South America, thriving across a variety of ecosystems, including the dry forests and savannas of Brazil, Argentina, Paraguay, and Bolivia, as well ...
Role of Artificial Intelligence in the Medical Field for the Early Prediction, Diagnosis, and Detection of Various Comorbidities [0.03%]
人工智能在医疗领域的角色：早期预测、诊断和检测各种并发症
Namrata Singh,Rashmi Verma,Richa Saxena et al.
Namrata Singh et al.
The increasing comorbidity rates, which are described as a patient having more than two medical conditions, present a significant problem in contemporary healthcare. The co-occurrence of various disorders makes their diagnosis challenging, ...