Relationship Between miRNA and Neurodegenerative Diseases Such as Alzheimer's disease, Parkinson's, Huntington's disease, Amyotrophic Lateral Sclerosis [0.03%]
microRNA与阿尔茨海默症、帕金森病、亨廷顿舞蹈病、肌萎缩侧索硬化症等神经退行性疾病的关系
Aysenur Keskin,Rasim Mogulkoc,Abdulkerim Kasim Baltaci
Aysenur Keskin
The regulatory roles of miRNAs on CNS homeostasis, neuronal differentiation, and synaptic plasticity make these molecules indispensable for healthy brain functions. miRNA dysregulation, by triggering abnormal neurodevelopment, has a critica...
Advances in the Understanding and Mechanisms of Cabergoline-induced Valvulopathy in Prolactinoma Patients [0.03%]
卡麦角林所致垂体泌乳素腺瘤患者瓣膜病的病因及机制研究进展
ZiLong Tan,TengTeng Wang,Wei He et al.
ZiLong Tan et al.
Prolactinomas are the most common neuroendocrine tumors of the pituitary and the leading cause of hyperprolactinemia. Dopamine Receptor Agonists (DAs), particularly cabergoline (CAB), effectively reduce prolactin levels and tumor volume, an...
Sulfonamides in Drug Discovery: A Review of Synthetic Approaches and Biological Activities [0.03%]
药物发现中的磺胺类化合物：合成方法与生物活性综述
Emmanuel Chinedu Nnadi,Vivian Ifeoma Okonkwo,Faith Temitope Elijah et al.
Emmanuel Chinedu Nnadi et al.
Sulfonamides represent one of the most versatile scaffolds in medicinal chemistry. Since their introduction as the first synthetic antibacterial agents in the 1930s, the sulfonamide functional group (-SO₂NR₂) has enabled extensive structu...
Recent Developments in Common Dietary Phytoconstituents: Insights into Structure-activity Relationship and Anti-breast Cancer Activity [0.03%]
常见膳食植物成分的最新研究进展：结构-活性关系及抗乳腺癌活性展望
Kumari Sunita Prajapati,Swanand Kulkarni,Smriti Choudhari et al.
Kumari Sunita Prajapati et al.
Breast cancer continues to threaten women's lives globally. Dietary phytochemicals are useful in combating breast cancer in preclinical and clinical research. Poor water solubility and bioavailability contribute to the failure of these drug...
Dismantling the TGF-β Axis: A Critical Transition from Occupancy-based Kinase Inhibitors to Event-driven Degraders [0.03%]
拆解TGF-β轴：从基于占用的激酶抑制剂到事件驱动降解剂的关键转变
Shasha Shen,Juan Li,Xue Cui et al.
Shasha Shen et al.
The TGF-β signaling pathway plays a dual role in cancer, acting as both a tumor suppressor and a potent driver of metastasis and immune evasion. Traditional TGF-β inhibitors, primarily ATP-competitive kinase blockers, have faced clinical ...
Mechanistic and Therapeutic Approach of Plants as an Anti-inflammatory Agent: A Review [0.03%]
植物作为抗炎剂的机制和治疗作用：综述
Komal Raghuvanshi,Mehak Thakur,Disha Raghuvanshi et al.
Komal Raghuvanshi et al.
Chronic inflammation is a prolonged immune response that leads to the development of numerous diseases, including arthritis, cardiovascular disorders, and metabolic syndromes. Currently, synthetic anti-inflammatory medications are widely us...
Smart Biopolymer Scaffolds for Oral and Craniofacial Regenerative Therapy: Translational Perspectives Toward Post-oral Cancer Repair - A Review [0.03%]
用于头颈部口腔癌术后缺损修复的智能生物聚合物支架：促进向临床转化的发展趋势及展望
Nandana S Krishnan,Shruthi Venkataraman,Ashok K Sundramoorthy
Nandana S Krishnan
Oral tissue defects following oral cancer treatments pose significant reconstruction challenges due to septic resection margins, residual cancer cells, and impaired angiogenesis. Conventional approaches like grafts suffer from limitations s...
Medicinal Chemistry Perspectives on Molecular Targets and Targeted Therapeutic Strategies in Breast Cancer [0.03%]
乳腺癌分子靶点及靶向治疗策略的药物化学观点
Dhinesh Kumar Murugesan,Kalirajan Rajagopal,Krishna Shevate et al.
Dhinesh Kumar Murugesan et al.
Breast cancer is one of the major causes of morbidity and mortality in cancer among women in the global society. The condition is highly heterogeneous and shows significant variation in molecular subtypes, clinical behaviour, and response t...
Herbal Extract-loaded Biomaterials for Bone Regeneration: Mechanisms of Action, Delivery Platform Optimization, and Translational Considerations [0.03%]
用于骨再生的中药提取物负载生物材料：作用机制、递送平台优化及转化考虑因素
Nakul Dhangar,Harshita Singhai,Sunny Rathee et al.
Nakul Dhangar et al.
Bone regeneration remains a major clinical challenge due to the limited bioactivity, high cost, and adverse effects associated with current grafts and synthetic therapeutics. Herbal phytometabolites, including flavonoids, alkaloids, and ter...
Ferrocene-based Drug Molecules in Medicinal Chemistry: Comprehensive Insights into their Chemistry, Pharmacology, and Emerging Therapeutic Applications [0.03%]
药物化学中的菲克森衍生物类药物分子：全面透视其化学、药理及新兴治疗应用
Ramling D Mali,Somnath Bhinge
Ramling D Mali
Introduction: Ferrocene, which was a milestone organometallic compound discovered in 1951, remains of interest in medicinal chemistry due to its exceptional stability, redox activity, and ease of functionalization, etc. A...