Indole Scaffolds in Neurological Therapeutics: Synthesis, Structure-Activity Relationships and Drug-Receptor Interactions [0.03%]
神经药物治疗中的吲哚支架：合成，构效关系和药物-受体相互作用
Alisha Bano,Ahsan Ahmed Khan,Shom Prakash Kushwaha et al.
Alisha Bano et al.
Introduction: Indole is a privileged heterocyclic scaffold that plays a crucial role in medicinal chemistry due to its strong ability to bind to various biological receptors and interact with diverse molecular targets. In...
A Comprehensive Review on Non-Natural Amino Acid-based Modifications in Antibacterial Peptides [0.03%]
基于非天然氨基酸修饰的抗菌肽研究进展综述
Yan Zhou,Xinghao Li,Ke Yang et al.
Yan Zhou et al.
Antimicrobial peptides are tiny molecular polypeptides that help living things fight off foreign microbes. According to recent studies, they come from a wide range of sources and can be found in a wide range of creatures, including microbes...
Recent Developments in Heterocyclic Derivatives as Novel Cancer Therapeutics: From 2020-2024 [0.03%]
2020-2024年杂环衍生物作为新型抗癌药物的最新进展
Sucheta Singh,Hrithik Dey,Meenakshi Kaira et al.
Sucheta Singh et al.
Despite progress in cancer research, cancer continues to be a leading cause of mortality worldwide; hence, therapeutic strategies must constantly improve. Drug discovery has revealed that heterocyclic moieties are fundamental and unique sca...
A Comprehensive Review of Designing and Synthetic Aspects of Pyrazolopyrimidine Derivatives as Anticancer Agents [0.03%]
吡唑并嘧啶衍生物作为抗肿瘤剂的设计和合成方面的综合述评
Preet Sagar,Yogita Sachin Ozarde,Vijaya Sachin Vichare et al.
Preet Sagar et al.
Background: Pyrazolopyrimidines are a fascinating class of heterocyclic compounds that have attracted considerable interest for their potential in cancer therapy. Their unique scaffold allows flexible chemical modificatio...
Manisha Nitin Veer,Neela Manish Bhatia
Manisha Nitin Veer
Breast cancer (BC) remains a leading cause of mortality worldwide, with treatment complicated by tumor heterogeneity, drug resistance, and therapy-related toxicities. Despite advances in chemotherapy, immunotherapy, and surgery, these chall...
Sagar V Patil,Mahidansha M Shaikh,Rajshekhar V Karpoomath et al.
Sagar V Patil et al.
Introduction: Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex, affects nearly 10 million people annually and remains the second-deadliest infectious disease after HIV/AIDS. The rise of multidrug-resist...
Potential of Small Molecule TAAR-1 Agonists for the Therapy of Neurodegenerative Psychosis: A Medicinal Chemistry Perspective [0.03%]
从药物化学角度看小分子TAAR-1激动剂治疗神经退行性精神病的潜力
Sandipan Dash,Sheik Shehensha,Arghya Kusum Dhar
Sandipan Dash
This comprehensive review critically evaluates the emerging therapeutic potential of small-molecule Trace Amine-Associated Receptor 1 (TAAR-1) agonists as a novel, diseasemodifying strategy for neurodegenerative psychosis. From a medicinal ...
Sudha Vengurlekar,Ravikant Gupta,Priyanka Nagar et al.
Sudha Vengurlekar et al.
The global rise in infectious diseases poses a significant threat to human health, creating an urgent need for novel therapeutic agents capable of effectively managing these conditions. Molecular hybridization has emerged as a promising str...
Bridging miRNA Research with Clinical Applications in Cardiovascular Diseases: Advances in Delivery Systems and Therapeutic Strategies [0.03%]
心血管疾病中microRNA研究与临床应用的桥梁：递送系统和治疗策略的进展
Shiping He,Xiaolin Li
Shiping He
MicroRNAs (miRNAs) are integral to the regulation of gene expression pertinent to cardiovascular health, affecting various biological processes, such as cell adhesion, inflammation, and lipid metabolism. Certain miRNAs (miR-1, miR-133a, miR...
Nuclei-targeted Therapeutic Delivery: A Novel Concept for the Treatment of Cancer [0.03%]
靶向细胞核的治疗递送：癌症治疗的新概念
Deepak Kumar,Rishabha Malviya,Sathvik Belagodu Sridhar
Deepak Kumar