Human P53 Expression in Yeast: Investigating Its Apoptotic Effects [0.03%]
人p53在酵母中的表达及其诱导细胞凋亡作用的初步研究
Sihem Ben Abid,Wafa Mihoubi,Ines Yacoubi et al.
Sihem Ben Abid et al.
Since its discovery in 1979, the tumor suppressor p53 has been widely studied and expressed in various organisms, including yeast. Yeast has proven to be a very informative model and an effective system for studying the roles and functions ...
Nanotechnology Meets Phytotherapy: A Comprehensive Review of Berberine in Cancer [0.03%]
纳米技术与植物药理学的结合：巴马汀在癌症中的综合评论
Istuti Saraswat,Anjana Goel,Jyoti Gupta
Istuti Saraswat
Cancer continues to pose a worldwide health concern, requiring breakthrough therapeutic approaches that are both efficacious and minimally intrusive. Berberine, a natural isoquinoline alkaloid, has attracted considerable interest due to its...
Unraveling the Multifunctional Therapeutic Potential of Topsentin: A Marine-derived Versatile Scaffold [0.03%]
揭秘拓普森丁的多功能治疗潜力：一种具有多种功能的海洋衍生支架分子
Navin Kumar Tailor,Sandeep Kumar Singh
Navin Kumar Tailor
Natural products (NPs) have long served as a rich inspirational source for drug discovery and development, offering diverse chemical structures and biological activities. Among these, topsentin, a marine alkaloid derived from marine sponges...
Innovations in Biosensing Technologies for Cancer Diagnosis and Theranostics [0.03%]
癌症诊断与治疗诊断技术的生物传感技术创新
Arpana Purohit,Amit Pratap Singh,Surbhi Tomar et al.
Arpana Purohit et al.
Cancer remains a major global health concern that demands the development of novel strategies for early identification, accurate treatment, and continuous monitoring of therapeutic outcomes. The search for new approaches to cancer managemen...
A Review of the Role of Poly (ADP-Ribose) Polymerase-1 (PARP1) and Its Inhibitors for Cancer Therapy [0.03%]
聚(腺苷二磷酸核糖)多聚酶-1(PARP1)及其抑制剂在癌症治疗中的作用综述
Mettu Omkar Bala Narasimha,Hardha Balachandran,Byran Gowramma et al.
Mettu Omkar Bala Narasimha et al.
Introduction: Poly (ADP-ribose) polymerase (PARP) regulates transcription, replication, DNA repair, and the cell cycle. This study examines the multiple functions of PARP beyond DNA repair, including its role in immunolog...
Advances in Fragment-based Drug Design: Lessons and Innovations from the Post-COVID Drug Discovery Landscape [0.03%]
基于片段的药物设计进展：后疫情时代药物发现带来的启示与创新
Vatan Chaudhary,Atul Pratap Singh,Himanchal Sharma et al.
Vatan Chaudhary et al.
Fragment-based drug discovery (FBDD) has emerged as a transformative strategy in modern medicinal chemistry, offering a rational and efficient alternative to traditional highthroughput screening (HTS). By utilizing small, low-molecular-weig...
A Mini-review on the Significance of Benzimidazole in Antifungal Drug Design: Past Insights and Current Applications [0.03%]
苯并咪唑在抗真菌药物设计中的意义：过去的研究和现在的应用微型评论
Aarti Singh,Anjali,Sumitra Nain
Aarti Singh
Benzimidazole and its derivatives have been extensively investigated for their antifungal activity, playing a crucial role in drug development. Initially, known for their agricultural applications, these compounds have evolved into signific...
Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection [0.03%]
苦味化合物作为治疗糖尿病相关认知障碍的多功能药物：代谢调节与神经保护之间的桥梁作用研究
Hao Wu,Ling He,Li Dai
Hao Wu
The increasing prevalence of diabetes-associated cognitive dysfunction (DACD), driven by accelerated aging and unhealthy lifestyles, poses a significant global public health challenge. The current understanding of DACD pathogenesis remains ...
Innovative Approaches to Alzheimer's Treatment: Utilizing Tacrine Hybrids to Inhibit Amyloid Beta Aggregation as a Strategic Focus [0.03%]
阿尔茨海默病治疗的创新方法——利用Tacrine衍生物抑制淀粉样蛋白聚集以作为战略重点
Angamuthu Prabakaran,Amuthulakshmi Sivaperuman,Ramalakshmi Natarajan et al.
Angamuthu Prabakaran et al.
Alzheimer's disease (AD) is a complex and progressive brain disorder marked by memory loss, cognitive decline, and behavioral changes. One of its defining features is the build-up of amyloid plaques, clumps of β-amyloid (Aβ) peptides, in ...
Vitamin C Conjugates in Biomedicine: A Comprehensive Exploration with Drugs, Polymers, Proteins, and Peptides [0.03%]
维生素C缀合物在生物医学中的全面探索——药物、聚合物、蛋白质和肽的综合研究
Sarika R Wavhale,Anwar R Shaikh
Sarika R Wavhale
Vitamin-drug conjugates are formed by linking a drug to a vitamin, either directly or through a spacer, to facilitate recognition and binding to receptors overexpressed on bacterial, cancer, or targeted cells. This strategy, often described...