Exploring the Therapeutic Potential of Sulfonamide-1,3,4-Thiadiazole Hybrids: Focus on Neurological and Infectious Diseases [0.03%]
磺胺-1,3,4-噻二唑杂化物治疗神经和感染疾病的潜力探索
Bharti Bansal,Monika Gupta
Bharti Bansal
The 1,3,4-thiadaizole is widely recognized in drug discovery for its favorable physicochemical characteristics and diverse range of biological activities. This heterocyclic compound contains a five-membered ring composed of nitrogen, carbon...
A Comprehensive Review on Homology Modelling in Drug Development: Methodologies, Tools, and Evaluation [0.03%]
药物开发中的同源模建综述：方法、工具及评估标准
Priyanshu Nema,Arpana Purohit,Vandana Soni et al.
Priyanshu Nema et al.
The large accumulation of genomic and proteomic data has clearly established the need for accurate prediction of protein structure, especially with a view to enabling structurebased drug design. There are numerous ways to do this on compute...
Computational Innovations in Cancer Research and How Computing is Transforming Drug Discovery and Development: A Review [0.03%]
计算在癌症研究中的创新及计算机技术如何变革药物发现与开发：综述文章
Ilavanalangki Lytan,Basanta Singha,Nichan Boruah et al.
Ilavanalangki Lytan et al.
Introduction: Cancer is a major global health concern, causing millions of deaths each year due to the uncontrolled growth and spread of abnormal cells. Despite advances in diagnosis and treatment, its complexity and ther...
Prema Vediappan,Swetha Aravamudhan,Jocelyn Olivia Prabhakar David et al.
Prema Vediappan et al.
Introduction: Antisense molecules are short synthetic nucleic acid strands designed to bind to complementary sequences of messenger RNA (mRNA) to regulate gene expression. This study focuses on understanding the chemistry...
Association of Metabolic Syndrome and Cholelithiasis: Understanding the Underlying Mechanism for Better Treatment [0.03%]
代谢综合征与胆石症的关联：深入了解其机制以更好地进行治疗
Anas Emmad Al Wahaibi,Abdullah Al Lawati,Maiyan Al Hinai et al.
Anas Emmad Al Wahaibi et al.
Metabolic syndrome is characterized by a combination of conditions, including abdominal obesity, elevated blood pressure, increased blood sugar levels, and high triglycerides. The incidence of metabolic syndrome is concerningly increasing w...
The Nasal Route Redefined: The Impact of Chitosan Nanoparticles on Drug Delivery [0.03%]
chitosan纳米颗粒对药物递送的影响：重新定义鼻给药途径
Lalit Kumar,Vikas Aggarwal,Ritesh Rana et al.
Lalit Kumar et al.
Introduction: The nasal route presents a viable alternative for medication administration, circumventing first-pass metabolism and improving bioavailability, especially for neurological conditions. Nonetheless, obstacles ...
New Therapeutic Options Against Clinically Relevant Proteases in Cancer Progression [0.03%]
针对癌症进展中临床相关蛋白酶的新治疗选择
Anastasiya O Syrocheva,Darya S Volkova,Evgenya R Denisova et al.
Anastasiya O Syrocheva et al.
Proteases are key regulators in cancer progression and metastasis, representing promising therapeutic targets. This review underscores the critical role of diverse proteases-encompassing cell surface ectoproteases, extracellular proteases, ...
Davide Barreca
Davide Barreca
Inavolisib-based Combination Therapy for the Treatment of PIK3CAMutated HR+/HER2- Breast Cancer: An Overview [0.03%]
针对PIK3CA突变HR+/HER2-乳腺癌的INAVOLISIB联合疗法：综述性分析
Sushmita Bhatia,Neha Bhatia,Suresh Thareja
Sushmita Bhatia
Inavolisib is a selective phosphoinositide 3-kinase alpha (PI3Kα) inhibitor representing the next generation of anticancer drugs for the treatment of PIK3CA-mutated HR+/HER2- breast cancer. The dysregulated PI3K/AKT/mTOR signalling axis is...
The Rise of Palladium Nanoparticles: From Fabrication to Biomedical Breakthroughs [0.03%]
钯纳米粒子的崛起：从制备到生物医学突破
Lalit Kumar,Ritesh Rana,Rakesh Kumar Sharma et al.
Lalit Kumar et al.
Introduction: Palladium nanoparticles (PdNPs) are at the vanguard of nanotechnologydriven biomedical and industrial applications due to their exceptional electronic, catalytic, and optical properties. ...