Florian Maumus,Pablo Rabinowicz,Chris Bowler et al.
Florian Maumus et al.
Epigenetics include DNA methylation, the modification of histone tails that affect chromatin states, and small RNAs that are involved in the setting and maintenance of chromatin modifications. Marine stramenopiles (MAS), which are a diverse...
The MADS and the Beauty: Genes Involved in the Development of Orchid Flowers [0.03%]
花開蝶自來－蝴蝶蘭花朵发育相关基因之研究
Serena Aceto,Luciano Gaudio
Serena Aceto
Since the time of Darwin, biologists have studied the origin and evolution of the Orchidaceae, one of the largest families of flowering plants. In the last two decades, the extreme diversity and specialization of floral morphology and the u...
Edward R Dougherty,Amin Zollanvari,Ulisses M Braga-Neto
Edward R Dougherty
Classification has emerged as a major area of investigation in bioinformatics owing to the desire to discriminate phenotypes, in particular, disease conditions, using high-throughput genomic data. While many classification rules have been p...
Genetics and mitochondrial abnormalities in autism spectrum disorders: a review [0.03%]
自闭症谱系障碍的遗传学及线粒体异常的研究进展综述
Sukhbir Dhillon,Jessica A Hellings,Merlin G Butler
Sukhbir Dhillon
We review the current status of the role and function of the mitochondrial DNA (mtDNA) in the etiology of autism spectrum disorders (ASD) and the interaction of nuclear and mitochondrial genes. High lactate levels reported in about one in f...
Paramutation: just a curiosity or fine tuning of gene expression in the next generation? [0.03%]
参变互作：一种奇观还是一种精细调控以调整下一代的基因表达？
Roberto Pilu
Roberto Pilu
Gene silencing is associated with heritable changes in gene expression which occur without changes in DNA sequence. In eukaryotes these phenomena are common and control important processes, such as development, imprinting, viral and transpo...
Keeping the balance between proliferation and differentiation: the primary cilium [0.03%]
增殖与分化的平衡：原纤毛的作用
Florencia Irigoín,Jose L Badano
Florencia Irigoín
Primary cilia are post-mitotic cellular organelles that are present in the vast majority of cell types in the human body. An extensive body of data gathered in recent years is demonstrating a crucial role for this organelle in a number of c...
Therapeutic challenges to retinitis pigmentosa: from neuroprotection to gene therapy [0.03%]
retina pigmentosa的治疗挑战：从神经保护到基因治疗
Jayashree N Sahni,Martina Angi,Cristina Irigoyen et al.
Jayashree N Sahni et al.
Syndromic retinitis pigmentosa (RP) is the result of several mutations expressed in rod photoreceptors, over 40 of which have so far been identified. Enormous efforts are being made to relate the advances in unraveling the patho-physiologic...
Diagnostic challenges in retinitis pigmentosa: genotypic multiplicity and phenotypic variability [0.03%]
视网膜色素变性诊断难题：基因型多样性和表型多态性
Susie Chang,Leah Vaccarella,Sunday Olatunji et al.
Susie Chang et al.
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders. Diagnosis can be challenging as more than 40 genes are known to cause non-syndromic RP and phenotypic expression can differ significantly resulting in variat...
Good epidemiologic practice in retinitis pigmentosa: from phenotyping to biobanking [0.03%]
视网膜色素变性良好的流行病学实践：从表型到生物库
Marzio Chizzolini,Alessandro Galan,Elisabeth Milan et al.
Marzio Chizzolini et al.
Inherited retinal dystrophies, such as retinitis pigmentosa (RP), include a group of relatively rare hereditary diseases caused by mutations in genes that code for proteins involved in the maintenance and function of the photoreceptor cells...
Clinical and Rehabilitative Management of Retinitis Pigmentosa: Up-to-Date [0.03%]
色素性视网膜炎的临床和康复管理：最新进展
Francesco Parmeggiani,Giovanni Sato,Katia De Nadai et al.
Francesco Parmeggiani et al.
The term retinitis pigmentosa (RP) indicates a heterogeneous group of genetic rare ocular diseases in which either rods or cones are prevalently damaged. RP represents the most common hereditary cause of blindness in people from 20 to 60 ye...