Challenges and solutions in the development of genomic biomarker panels: a systematic phased approach [0.03%]
基因组生物标志物面板开发的挑战与解决方案：系统分期方法
K Shahzad,A Fatima,M Cadeiras et al.
K Shahzad et al.
In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personali...
Identification of pharmacological targets in amyotrophic lateral sclerosis through genomic analysis of deregulated genes and pathways [0.03%]
通过基因和途径的基因组分析鉴定肌萎缩性侧索硬化症的药理学靶点
Sabrina Paratore,Salvatore Pezzino,Sebastiano Cavallaro
Sabrina Paratore
Amyotrophic Lateral Sclerosis (ALS) is a progressive and disabling neurodegenerative disorder characterized by upper and lower motor neuron loss, leading to respiratory insufficiency and death after 3-5 years. Riluzole is currently the only...
The Pharmacogenomic HLA Biomarker Associated to Adverse Abacavir Reactions: Comparative Analysis of Different Genotyping Methods [0.03%]
ABCAVIK基因分型的HLA生物标志物的药妆联合组学研究比较分析不同的基因分型方法
Laura Stocchi,Raffaella Cascella,Stefania Zampatti et al.
Laura Stocchi et al.
Many pharmacogenomic biomarkers (PGBM) were identified and translated into clinical practice, affecting the usage of drugs via label updates. In this context, abacavir is one of the most brilliant examples of pharmacogenetic studies transla...
Mukesh Verma
Mukesh Verma
After completion of the human genome, genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with cancer initiation and progression. Most of the studies identified SNPs that were located...
Aj Durston,S Wacker,N Bardine et al.
Aj Durston et al.
The vertebrate A-P axis is a time axis. The head is made first and more and more posterior levels are made at later and later stages. This is different to the situation in most other animals, for example, in Drosophila. Central to this timi...
Joost M Woltering
Joost M Woltering
The elongated, snake-like skeleton, as it has convergently evolved in numerous reptilian and amphibian lineages, is from a developmental biologist's point of view amongst the most fascinating anatomical peculiarities in the animal kingdom. ...
Building a robust a-p axis [0.03%]
构建稳健的a-p轴
Alysha Heimberg,Edwina McGlinn
Alysha Heimberg
Since the last common ancestor of Metazoa, animals have evolved complex body plans with specialized cells and spatial organization of tissues and organs. Arguably, one of the most significant innovations during animal evolutionary history w...
Collective epithelial and mesenchymal cell migration during gastrulation [0.03%]
原肠运动中的上皮细胞和间质细胞的集体迁移现象
Manli Chuai,David Hughes,Cornelis J Weijer
Manli Chuai
Gastrulation, the process that puts the three major germlayers, the ectoderm, mesoderm and endoderm in their correct topological position in the developing embryo, is characterised by extensive highly organised collective cell migration of ...
Aj Durston
Aj Durston
Jesús Delgado-Calle,Pablo Garmilla,José A Riancho
Jesús Delgado-Calle
Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are embedded. Besides providing the internal support of the body and protection for vital organs, bone also has several important metabolic functio...