Employing genetic markers to improve diagnosis of thyroid tumor fine needle biopsy [0.03%]
应用遗传标记以提高甲状腺肿瘤细针穿刺活检的诊断效力
Janete M Cerutti
Janete M Cerutti
Fine-Needle Aspiration (FNA) is the most widely used and cost-effective preoperative test for the initial evaluation of a thyroid nodule, although it has limited diagnostic accuracy for several types of tumors. Patients will often receive c...
Katja Zaletel,Simona Gaberšček
Katja Zaletel
Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Intrathyroidal lymphocytic infiltration is followed by a gradual destruction of the thyroid gland which may lead to subclinical or overt hypothyroidism. Biochem...
Omid Khalilzadeh,Sina Noshad,Armin Rashidi et al.
Omid Khalilzadeh et al.
Graves' disease (GD) is the most common cause of thyrotoxicosis and often involves the orbits. Graves' ophthalmopathy (GO), also known as Thyroid Eye Disease (TED), can be clinically significant and advance to sight-threatening stages. Our ...
Rafał Płoski,Konrad Szymański,Tomasz Bednarczuk
Rafał Płoski
The presented comprehensive review of current knowledge about genetic factors predisposing to Graves' disease (GD) put emphasis on functional significance of observed associations. In particular, we discuss recent efforts aimed at refining ...
Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions [0.03%]
自身免疫性甲状腺疾病的遗传易感基因及功能研究新进展
Oliver J Brand,Stephen C L Gough
Oliver J Brand
The autoimmune thyroid diseases (AITD) include Graves' disease (GD) and Hashimoto's thyroiditis (HT), which are characterised by a breakdown in immune tolerance to thyroid antigens. Unravelling the genetic architecture of AITD is vital to b...
Katja Zaletel
Katja Zaletel
Susan Moore,Eric Kelleher,Aiden Corvin
Susan Moore
A growing list of common and rare genetic risk variants are being implicated in schizophrenia susceptibility. As with other complex genetic disorders most of the variance in genetic risk is still to be attributed. What can be learned from p...
Can transcriptomics cut the gordian knot of amyotrophic lateral sclerosis? [0.03%]
转录组学能否解开肌萎缩侧索硬化症的 Gordian 结扣？
Alexandre Henriques,Jose-Luis Gonzalez De Aguilar
Alexandre Henriques
Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disease characterized by the loss of upper and lower motor neurons, progressive muscle atrophy, paralysis and death, which occurs within 2-5 years of diagnosis. Most cases a...
Sunipa Majumdar,Eric Buckles,John Estrada et al.
Sunipa Majumdar et al.
Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and a leading cause of cancer-related death in men in Western industrialized countries. In contrast to genetic changes that vary among individual cas...
GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss [0.03%]
GJB2基因突变与综合征性神经皮肤疾病相关聋的关联研究
Sandra Iossa,Elio Marciano,Annamaria Franzé
Sandra Iossa
The GJB2 gene is located on chromosome 13q12 and it encodes the connexin 26, a transmembrane protein involved in cell-cell attachment of almost all tissues. GJB2 mutations cause autosomal recessive (DFNB1) and sometimes dominant (DFNA3) non...